Category: 2240-88-2

Waterland, R. L. published the artcileGas phase UV and IR absorption spectra of CF₃CH₂CH₂OH and F(CF₂CF₂)_xCH₂CH₂OH (χ = 2, 3, 4), Safety of 3,3,3-Trifluoropropan-1-ol, the publication is Journal of Fluorine Chemistry (2005), 126(9-10), 1288-1296, database is CAplus.

The UV and IR spectra of CF₃CH₂CH₂OH and F(CF₂CF₂)_xCH₂CH₂OH (χ = 2, 3, 4) were studied using computational and exptl. techniques. Computational methods were used to show that CF₃CH₂CH₂OH and F(CF₂CF₂)_xCH₂CH₂OH (χ = 2, 3) have UV absorption at λ = 140-175 nm. Photolysis is therefore not a significant environmental loss mechanism for fluorinated alcs. Exptl. methods were used to record IR spectra for CF₃CH₂CH₂OH and F(CF₂CF₂)_xCH₂CH₂OH (χ = 2, 3, 4) at spectral resolutions of 0.004-0.5 cm^-1 with, and without, 700 torr of air diluent. There was no discernable effect of total pressure or spectral resolution over the range studied. Calculated IR spectra agreed with those measured exptl., and were used to assign the IR spectra.

Journal of Fluorine Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C12H25Br, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shinkai, Takahiro published the artcileInfrared spectroscopy and theoretical structure analyses of protonated fluoroalcohol clusters: the impact of fluorination on the hydrogen bond networks, Application In Synthesis of 2240-88-2, the publication is Physical Chemistry Chemical Physics (2022), 24(20), 12631-12644, database is CAplus and MEDLINE.

To explore the impact of fluorination on the hydrogen bond networks of protonated alkylalcs., IR spectroscopy and theor. computations of protonated 2,2,2-trifluoroethanol clusters, H⁺(TFE)_n, (n = 4-7), were performed. It has been demonstrated that the development of the hydrogen bond networks from a linear type to cyclic types occurs in this size region for the protonated alkylalc. clusters. In contrast, IR spectroscopy of H⁺(TFE)_n in the OH/CH stretch region clearly indicated that the linear type structures are held in the whole size range, irresp. of temperature of the clusters. The extensive stable isomer structure search of H⁺(TFE)_n based on our latest sampling approach supported the strong preference of the linear type hydrogen bond networks. Detailed analyses of the free OH stretching vibrational bands evidenced the intra- and intermol. OH···FC interactions in the clusters. In addition, IR spectra of protonated clusters of 2,2-difluoroethanol, 2,2-difluoropropanol, and 3,3,3-trifluoropropanol were measured for n = 4 and 5, and their spectra also indicated the effective inhibition of the cyclic hydrogen bond network formation by the fluorination.

Physical Chemistry Chemical Physics published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C10H10N2, Application In Synthesis of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hashimoto, Yuka published the artcilePhoto-on-Demand Base-Catalyzed Phosgenation Reactions with Chloroform: Synthesis of Arylcarbonate and Halocarbonate Esters, Related Products of alcohols-buliding-blocks, the publication is Journal of Organic Chemistry (2021), 86(14), 9811-9819, database is CAplus and MEDLINE.

Carbonate esters are utilized as solvents and reagents for C1 building blocks in organic synthesis. This study reports a novel photo-on-demand in situ synthesis of carbonate esters with CHCl₃ solutions containing a mixture of an aromatic or haloalkyl alc. having relatively high acidity, and an organic base. We found that the acid-base interaction of the alc. and base in the CHCl₃ solution plays a key role in enabling the photochem. reaction. This reaction allows practical syntheses of di-Ph carbonate derivatives, haloalkyl carbonates, and polycarbonates, which are important chems. and materials in industry.

Journal of Organic Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiang, Bowen published the artcileFluorinated paclitaxel prodrugs for potentiated stability and chemotherapy, SDS of cas: 2240-88-2, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2021), 9(48), 9971-9979, database is CAplus and MEDLINE.

Robust colloidal stability is an essential prerequisite for effective drug delivery. Herein, a series of fluorinated paclitaxel prodrugs bridged with redox-responsive linkages were synthesized, and the effect of fluorination on the assembly behavior and physiol. stability was investigated. The 17-fluorinated ethanol-modified paclitaxel prodrug could self-assemble into stable nanoparticles without the addition of any surfactants. Fluorinated paclitaxel prodrug nanoparticles possessed potent cytotoxicity toward cancer cells and superior antitumor activity. This study offers a universal fluorination approach to improve drug delivery efficacy by enhancing the self-assembly capability and improving the colloidal stability of prodrugs for potentiating chemotherapy.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shi, Da-Hua published the artcileSynthesis of 3-(alkylamino)-, 3-(alkoxy)-, 3-(aryloxy)-, 3-(alkylthio)-, and 3-(arylthio)-1,2,4-triazines by using a unified route with 3-(methylsulfonyl)-1,2,4-triazine, COA of Formula: C3H5F3O, the publication is European Journal of Organic Chemistry (2016), 2016(16), 2842-2850, database is CAplus.

In our attempts to synthesize 3-(alkylthio)- and 3-(alkoxy)-1,2,4-triazines without substituents at the 5- or 6-position, the synthesis of their anticipated precursor 3-(methylsulfonyl)-1,2,4 triazine was also optimized. The reactivity of 3-(methylsulfonyl)-1,2,4-triazine towards alkyl and aryl thiols, primary and secondary alkylamines, phenols, and alcs. was explored, and the reactions were optimized to maximize the isolation of the corresponding 3-substituted 1,2,4-triazine. Good yields were obtained for the products of the reactions with all of the aforementioned nucleophiles, with the exception of alcs., by using alkali metal carbonates. Higher yields of 3-(alkoxy)-1,2,4-triazines were obtained by using the appropriate magnesium alkoxide as the nucleophile.

European Journal of Organic Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C16H12O, COA of Formula: C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Doura, Tomohiro published the artcileAn adhesive ¹⁹F MRI chemical probe allows signal off-to-on-type molecular sensing in a biological environment, Application of 3,3,3-Trifluoropropan-1-ol, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(97), 11421-11423, database is CAplus and MEDLINE.

We report a new strategy for designing a signal off-to-on-type ¹⁹F MRI chem. probe that operates in biol. environments. The present strategy is based on the control of adherence of a ¹⁹F MRI chem. probe to certain blood proteins, accompanied by a change in transverse relaxation time of ¹⁹F nuclei.

Chemical Communications (Cambridge, United Kingdom) published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Pingsheng published the artcileFluorine Meets Amine: Reducing Microenvironment-Induced Amino-Activatable Nanoprobes for ¹⁹F-Magnetic Resonance Imaging of Biothiols, SDS of cas: 2240-88-2, the publication is ACS Applied Materials & Interfaces (2018), 10(22), 18532-18542, database is CAplus and MEDLINE.

¹⁹F-magnetic resonance imaging (MRI) is of great significance for noninvasive imaging and detection of various diseases. However, the main obstacle in the application of ¹⁹F-MRI agents stems from the unmet signal sensitivity due to the poor water solubility and restricted mobility of segments with high number of fluorine atoms. Herein, the authors report a kind of intracellular reducing microenvironment-induced amino-activatable ¹⁹F-MRI nanoprobe, which can be used for specific imaging of biothiols. In principle, the nanoprobe has an initial architecture of hydrophobic core, where the trifluoromethyl-containing segments are compactly packed and ¹⁹F NMR/MRI signals are quenched (“OFF” state). Upon encountering sulfydryl, the strong electron-withdrawing 2,4-dinitrobenzenesulfonyl groups are excised to recover secondary amino groups, whose pK_a is 7.21. As a consequence, the mol. weight loss of the hydrophobic segment and the protonation of amino groups induce significant disturbance of hydrophilic/hydrophobic balance, leading to the disassembly of the nanoprobes and regain of spin-spin relaxation and ¹⁹F NMR/MRI signals (“ON” state, T₂ up to 296 ± 5.3 ms). This nanoprobe shows high sensitivity and selectivity to biothiols, enabling intracellular and intratumoral imaging of glutathione. The authors’ study not only provides a new nanoprobe candidate for biothiols imaging in vivo but also a promising strategy for the mol. design of real water-soluble and highly sensitive ¹⁹F-MRI nanoprobes.

ACS Applied Materials & Interfaces published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Zhuming published the artcileGut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer, COA of Formula: C3H5F3O, the publication is Journal of Medicinal Chemistry (2021), 64(15), 11570-11596, database is CAplus and MEDLINE.

Selective cyclooxygenase (COX)-2 inhibitors have been extensively studied for colorectal cancer (CRC) chemoprevention. Celecoxib has been reported to reduce the incidence of colorectal adenomas and CRC but is also associated with an increased risk of cardiovascular events. Here, we report a series of gut-restricted, selective COX-2 inhibitors characterized by high colonic exposure and minimized systemic exposure. By establishing acute ex vivo ¹⁸F-FDG uptake attenuation as an efficacy proxy, we identified a subset of analogs that demonstrated statistically significant in vivo dose-dependent inhibition of adenoma progression and survival extension in an APC^min/+ mouse model. However, in vitro-in vivo correlation anal. showed their chemoprotective effects were driven by residual systemic COX-2 inhibition, rationalizing their less than expected efficacies and highlighting the challenges associated with COX-2-mediated CRC disease chemoprevention.

Journal of Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is 0, COA of Formula: C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Price, David A. published the artcileHigh throughput synthesis of functionalized 1,3-diones and subsequent heterocycle formation, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Synlett (2002), 1170-1172, database is CAplus.

Treatment of 3,5-heptanedione with iodosylbenzene followed by reaction with aliphatic and benzylic alcs. ROH [R = F₃CCH₂CH₂, EtCMe₂, 3-MeOC₆H₄CH₂, PhO(CH₂)₃, cyclopropylmethyl, etc.] gave the corresponding 4-alkoxy-3,5-heptanediones, which in situ underwent heterocyclization with hydrazine to afford alkoxy-substituted pyrazoles I in 10-40% total yields.

Synlett published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Andrieux, Claude P. published the artcileEvidence for Inverted Region Behavior in Proton Transfer to Carbanions, Application of 3,3,3-Trifluoropropan-1-ol, the publication is Journal of the American Chemical Society (2003), 125(33), 10119-10124, database is CAplus and MEDLINE.

The diphenylmethane-diphenylmethyl anion acid/base couple in N,N-dimethylformamide is taken as an example for investigating the dynamics of proton transfer at carbon in a system where the acid is not activated by an electron-withdrawing group or by removal of an electron. The laser flash electron photoinjection technique is applied to the determination of the rate constant for the protonation of diphenylmethyl anion by an extended series of acids that offers a range of driving forces encompassing over 1.2 eV. The plot of the rate constant vs. the pK_a difference between diphenylmethane and the acids or of the activation free energy vs. the standard free energy of the reaction exhibits clear “inverted region” behavior (by a factor of 80 in terms of rate constants). While such behaviors have been predicted and observed for outer-sphere electron-transfer reactions, previous evidence for proton-transfer reactions was scarce. Entropic factors, derived from an investigation of the temperature dependence of the exptl. rate constants, are also discussed.

Journal of the American Chemical Society published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts