Category: 2240-88-2

Sam, Brannon published the artcileRuthenium-Catalyzed C-C Coupling of Fluorinated Alcohols with Allenes: Dehydrogenation at the Energetic Limit of β-Hydride Elimination, Application In Synthesis of 2240-88-2, the publication is Angewandte Chemie, International Edition (2015), 54(18), 5465-5469, database is CAplus and MEDLINE.

Ruthenium(II) complexes catalyze the C-C coupling of 1,1-disubstituted allenes and fluorinated alcs. to form homoallylic alcs. bearing all-carbon quaternary centers with good to complete levels of diastereoselectivity. Whereas fluorinated alcs. are relatively abundant and tractable, the corresponding aldehydes are often not com. available because of their instability.

Angewandte Chemie, International Edition published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application In Synthesis of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xie, Long-Yong published the artcileC(sp²)-H/O-H cross-dehydrogenative coupling of quinoxalin-2(1H)-ones with alcohols under visible-light photoredox catalysis, SDS of cas: 2240-88-2, the publication is Chinese Journal of Catalysis (2020), 41(8), 1168-1173, database is CAplus.

An efficient and practical route to various 3-alkoxylquinoxalin-2(1H)-ones through visible-light photocatalytic C(sp²)-H/O-H cross-dehydrogenation coupling of quinoxalin-2(1H)-ones and alcs. by employing ambient air as an oxidant at room temperature under metal-free conditions was developed.

Chinese Journal of Catalysis published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H9ClOS, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Fabao published the artcileChiroptical aggregates from block copolymer bearing amino acid moieties in aqueous solution, Related Products of alcohols-buliding-blocks, the publication is Journal of Polymer Science, Part B: Polymer Physics (2009), 47(14), 1345-1355, database is CAplus.

Optically active poly(ethylene glycol) monomethyl ether-b-poly(methacryloyl-L-leucine Me ester) (denoted as MPEG-b-PMALM) copolymers were prepared via atom transfer radical polymerization (ATRP), using bromine (Br) end-capped poly(ethylene glycol) monomethyl ether (denoted as MPEG-Br) as macroinitiator in the presence of CuBr/tris(2-dimethylaminoethyl)amine (Me₆TREN) as catalytic system. Broad range of morphologies, such as spherical, cylindrical, and vesicular micelles, which were prepared by initially dissolving prepared polymer in organic solvent at different concentration followed by addition various amount of water before dialysis against water to remove any added solvent, was observed by transmission electron microscope (TEM). More detailed chiroptical properties of the micelles/aggregates in aqueous solution were evaluated by CD spectroscopy as a function of micelles morphologies, polymer concentration, solvents employed, temperature, etc. The micellar solutions exhibit almost the same CD spectra regardless of its morphologies. The intensity of the CD spectra of the cylindrical micelles decreased in the molar ellipticities as the micellar concentration in water was increased. The Cotton effect was markedly changed when the solvent hydrophobicity was changed by addition of trifluoromethyl ethanol (TFME) to water. The intensity of the CD spectra decreased not too much within the temperature range from 20° to 90°, indicating good stability of the micelles upon temperature variation. © 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 47: 1345-1355, 2009.

Journal of Polymer Science, Part B: Polymer Physics published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C12H14O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tian, Yunfei published the artcileH-Bonding-promoted radical addition of simple alcohols to unactivated alkenes, Quality Control of 2240-88-2, the publication is Green Chemistry (2017), 19(21), 5230-5235, database is CAplus.

A H-Bonding-induced radical addition of simple alcs. such as ethanol, cyclohexanol, 2,2,2-trifluoroethan-1-ol, etc. to unactivated olefins e.g., 4-BrC₆H₄C(O)O(CH₂)₃HC=CH₂ was achieved. It effectively solved the long-standing problems of reactivity and selectivity in this type of reaction. The hydroxyalkylation occurred via site-specific cleavage of the α-hydroxyl-C-H bond in alcs. This method allows a highly atom-economical, operationally simple and environmentally benign access to diverse alcs. such as 6-phenylhexan-2-ol, 1-cyclooctylethanol, 3-(1-hydroxycyclopentyl)propyl 4-bromobenzoate, etc. diols, e.g., 4,5-dihydroxypentyl 4-bromobenzoate and even polyfluorinated alcs., e.g., 7,7,7-trifluoro-6-hydroxyheptyl 4-bromobenzoate. These useful chems. are traditionally synthesized by using com. unavailable organometallics via complex operations. In contrast, they can be facilely obtained through this protocol utilizing widely available starting materials.

Green Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C14H10O4, Quality Control of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Feng, Zujian published the artcileSuperhydrophilic fluorinated polymer and nanogel for high-performance ¹⁹F magnetic resonance imaging, Formula: C3H5F3O, the publication is Biomaterials (2020), 120184, database is CAplus and MEDLINE.

¹⁹F magnetic resonance imaging (¹⁹F MRI), a kind of non-invasive and non-radioactive diagnostic technique with no endogenous background signals, opens up new research avenues for accurate mol. imaging studies. However, ¹⁹F MRI is manily limited by the performance of contrast agents. Here, for the first time, we presented the zwitterionic fluorinated polymer and nanogel as new types of superhydrophilic, sensitive and ultra-stable ¹⁹F MRI contrast agents. The superhydrophilicity of carboxybetaine zwitterionic structure completely overcame the hydrophobic aggregation-induced signal attenuation associated with amphiphilic fluorinated polymer-based nanoprobes. In addition, the superhydrophilic contrast agent exhibited distinct advantages, including high ¹⁹F-content (19.1 wt%), superior resistance to protein adsorption, constant MR properties and ¹⁹F MRS-based quant. determination in complex biol. fluids, and intense ¹⁹F MRI signals in the whole-body images after i.v. injection. In combination with angiogenesis targeting ligand, the superhydrophilic contrast agent was applied for the unambiguous detection of tumor. Importantly, computational algorithm was established for the directly quant. determination of bioavailability and tumor-to-whole body ratio (TBR) from the in vivo¹⁹F MRI dataset, providing real-time information with non-invasive manner. Finally, crosslinked nanogels were developed with significantly prolonged systemic circulation, of which intense ¹⁹F MRI signals nonspecifically distributed in the aortaventralis and blood-rich organs, instead of being trapped steadily in liver as with the state-of-the-art superhydrophobic perfluocarbon nanoemulsions. Overall, this kind of superhydrophilic, zwitterionic fluorinated polymer and nanogel could be defined as a new generation of high-performance ¹⁹F MRI contrast agents, which hold great potential for image-based unambiguous disease detection and computational quantification.

Biomaterials published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Formula: C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tessensohn, Malcolm E. published the artcileMeasuring the Relative Hydrogen-Bonding Strengths of Alcohols in Aprotic Organic Solvents, Safety of 3,3,3-Trifluoropropan-1-ol, the publication is ChemPhysChem (2015), 16(1), 160-168, database is CAplus and MEDLINE.

Voltammetric experiments with 9,10-anthraquinone and 1,4-benzoquinone performed under controlled moisture conditions indicate that the hydrogen-bond strengths of alcs. in aprotic organic solvents can be differentiated by the electrochem. parameter ΔE_p^red = |E_p^red(1)-E_p^red(2)|, which is the potential separation between the two 1-electron reduction processes. This electrochem. parameter is inversely related to the strength of the interactions and can be used to differentiate between primary, secondary, tertiary alcs., and even diols, as it is sensitive to both their steric and electronic properties. The results are highly reproducible across two solvents with substantially different hydrogen-bonding properties (CH₃CN and CH₂Cl₂) and are supported by d. functional theory calculations The numerous solvent-alc. interactions are less significant than the quinone-alc. hydrogen-bonding interactions. The utility of ΔE_p^red was illustrated by comparisons between (1) 3,3,3-trifluoro-n-propanol and 1,3-difluoroisopropanol and (2) ethylene glycol and 2,2,2-trifluoroethanol.

ChemPhysChem published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C6H12Br2, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gilbert, Audrey published the artcileSynthesis of N-(2-SF₅-ethyl)amines and impact of the SF₅ substituent on their basicity and lipophilicity, SDS of cas: 2240-88-2, the publication is Tetrahedron (2021), 132424, database is CAplus.

The synthesis of N-(2-SF₅-ethyl)amines e.g., I is reported via the S_N2 reaction between various amines, e.g., Me (2S)-pyrrolidine-2-carboxylate and 2-(pentafluoro-λ⁶-sulfanyl)ethyl trifluoromethanesulfonate as the SF₅-containing electrophile. A total of 14 examples of SF₅-containing aliphatic amines were synthesized, with yields going from 19 to 92%. Moreover, the effect of the SF₅ substituent on the basicity and the lipophilicity of the amine was evaluated, and the SF₅ group showed to decrease both the pK_aH and the log D (pH = 7.0) values.

Tetrahedron published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tessensohn, Malcolm E. published the artcileMeasuring the Relative Hydrogen-Bonding Strengths of Alcohols in Aprotic Organic Solvents, Safety of 3,3,3-Trifluoropropan-1-ol, the publication is ChemPhysChem (2015), 16(1), 160-168, database is CAplus and MEDLINE.

Voltammetric experiments with 9,10-anthraquinone and 1,4-benzoquinone performed under controlled moisture conditions indicate that the hydrogen-bond strengths of alcs. in aprotic organic solvents can be differentiated by the electrochem. parameter ΔE_p^red = |E_p^red(1)-E_p^red(2)|, which is the potential separation between the two 1-electron reduction processes. This electrochem. parameter is inversely related to the strength of the interactions and can be used to differentiate between primary, secondary, tertiary alcs., and even diols, as it is sensitive to both their steric and electronic properties. The results are highly reproducible across two solvents with substantially different hydrogen-bonding properties (CH₃CN and CH₂Cl₂) and are supported by d. functional theory calculations The numerous solvent-alc. interactions are less significant than the quinone-alc. hydrogen-bonding interactions. The utility of ΔE_p^red was illustrated by comparisons between (1) 3,3,3-trifluoro-n-propanol and 1,3-difluoroisopropanol and (2) ethylene glycol and 2,2,2-trifluoroethanol.

ChemPhysChem published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C6H12Br2, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gilbert, Audrey published the artcileSynthesis of N-(2-SF₅-ethyl)amines and impact of the SF₅ substituent on their basicity and lipophilicity, SDS of cas: 2240-88-2, the publication is Tetrahedron (2021), 132424, database is CAplus.

The synthesis of N-(2-SF₅-ethyl)amines e.g., I is reported via the S_N2 reaction between various amines, e.g., Me (2S)-pyrrolidine-2-carboxylate and 2-(pentafluoro-λ⁶-sulfanyl)ethyl trifluoromethanesulfonate as the SF₅-containing electrophile. A total of 14 examples of SF₅-containing aliphatic amines were synthesized, with yields going from 19 to 92%. Moreover, the effect of the SF₅ substituent on the basicity and the lipophilicity of the amine was evaluated, and the SF₅ group showed to decrease both the pK_aH and the log D (pH = 7.0) values.

Tetrahedron published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Le, Thuy G. published the artcileStructure-activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of Haemonchus contortus development, Product Details of C3H5F3O, the publication is Journal of Medicinal Chemistry (2019), 62(2), 1036-1053, database is CAplus and MEDLINE.

Recently, we have discovered that the registered pesticide, tolfenpyrad, unexpectedly and potently inhibits the development of the L4 larval stage of the parasitic nematode Haemonchus contortus with an IC₅₀ value of 0.03 μM while displaying good selectivity, with an IC₅₀ of 37.9 μM for cytotoxicity. As a promising mol. template for medicinal chem. optimization, we undertook anthelmintic structure-activity relationships for this chem. Modifications of the left-hand side (LHS), right-hand side (RHS), and middle section of the scaffold were explored to produce a set of 57 analogs. Analogs I, II, and III were shown to be the most potent compounds of the series, with IC₅₀ values at a subnanomolar level of potency against the chemotherapeutically relevant fourth larval (L4) stage of H. contortus. Selected compounds from the series also showed promising activity against a panel of other different parasitic nematodes, such as hookworms and whipworms.

Journal of Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Product Details of C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts