Category: 2240-88-2

Styler, Sarah A. published the artcileHeterogeneous Photooxidation of Fluorotelomer Alcohols: A New Source of Aerosol-Phase Perfluorinated Carboxylic Acids, SDS of cas: 2240-88-2, the publication is Environmental Science & Technology (2013), 47(12), 6358-6367, database is CAplus and MEDLINE.

Little is known of the atm. fate(s) of fluorotelomer alcs. (FTOHs), a class of high-production-volume chems. used in the production of H₂O- and oil-repelling surface coatings and which have been detected in a wide variety of urban and remote environmental matrixes. We studied the uptake and photochem. of FTOHs at the surface of TiO₂, Fe₂O₃, Mauritanian sand, and Icelandic volcanic ash. Gas-phase 3,3,3-trifluoropropanol, 4:2 FTOH, and 6:2 FTOH exhibited significant uptake to each of the surfaces under study. The sand- and ash-catalyzed heterogeneous photooxidation of 6:2 FTOH resulted in the rapid production and subsequent slow degradation of surface-sorbed perfluorinated carboxylic acids (PFCAs). We suggest that this transformation, which proceeds via saturated and unsaturated fluorotelomer carboxylic acid intermediates (6:2 FTCA/FTUCA), is catalyzed by Fe and Ti contained within the samples. These results provide the 1st evidence that the heterogeneous oxidation of FTOHs at metal-rich atm. surfaces may provide a significant loss mechanism for these chems. and also act as a source of aerosol-phase PFCAs close to source regions. Subsequent long-range transport of these aerosol-sorbed PFCAs has the potential to join oceanic transport and local gas-phase FTOH oxidation as a source of PFCAs to Arctic regions.

Environmental Science & Technology published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C12H19BrS, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kikugawa, Yasuo published the artcileIntramolecular Cyclization with Nitrenium Ions Generated by Treatment of N-Acylaminophthalimides with Hypervalent Iodine Compounds: Formation of Lactams and Spiro-Fused Lactams, Safety of 3,3,3-Trifluoropropan-1-ol, the publication is Journal of Organic Chemistry (2003), 68(17), 6739-6744, database is CAplus and MEDLINE.

In hexafluoroisopropyl alc., N-phthalimido-N-acylnitrenium ions, generated from N-acylamino phthalimides I [X = O, CH₂, (CH₂)₂, (CH₂)₃, OCH₂, etc.; R = H, 4-Me, 2-Cl, 4-MeO, 2,4-F₂, etc.] by treatment with hypervalent iodine compounds, phenyliodine bis(trifluoroacetate) (PIFA) or its 4-chloro-substituted derivative, underwent intramol. electrophilic substitution reactions to afford N-phthalimido azaheterocycles II in high yields. Treatment of I [X = OCH₂, (CH₂)₂, (CH₂)₃] with PIFA or [hydroxy(tosyloxy)iodo]benzene (HTIB) in 2,2,2-trifluoroethanol gave spirodienones, e.g. III, as a result of ipso attack of the intermediate nitrenium ion.

Journal of Organic Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hurley, Michael D. published the artcileAtmospheric Chemistry of CF₃CH₂CH₂OH: Kinetics, Mechanisms and Products of Cl Atom and OH Radical Initiated Oxidation in the Presence and Absence of NO_x, Application In Synthesis of 2240-88-2, the publication is Journal of Physical Chemistry A (2005), 109(43), 9816-9826, database is CAplus and MEDLINE.

Relative rate techniques were used to study the kinetics of the reactions of Cl atoms and OH radicals with CF₃CH₂C(O)H and CF₃CH₂CH₂OH in 700 Torr of N₂ or air diluent at 296 ± 2 K. The rate constants determined were k(Cl+CF₃CH₂C(O)H) = (1.81 ± 0.27) x 10^-11, k(OH+CF₃CH₂C(O)H) = (2.57 ± 0.44) x 10^-12, k(Cl+CF₃CH₂CH₂OH) = (1.59 ± 0.20) x 10^-11, and k(OH+CF₃CH₂CH₂OH) = (6.91 ± 0.91) x 10^-13 cm³ mol.^-1 s^-1. Product studies of the chlorine initiated oxidation of CF₃CH₂CH₂OH in the absence of NO show the sole primary product to be CF₃CH₂C(O)H. Product studies of the chlorine initiated oxidation of CF₃CH₂CH₂OH in the presence of NO show the primary products to be CF₃CH₂C(O)H (81%), HC(O)OH (10%), and CF₃C(O)H. Product studies of the chlorine initiated oxidation of CF₃CH₂C(O)H in the absence of NO show the primary products to be CF₃C(O)H (76%), CF₃CH₂C(O)OH (14%), and CF₃CH₂C(O)OOH (≤10%). As part of this work, an upper limit of k(O₃+CF₃CH₂CH₂OH) < 2 × 10^-21 cm³ mol.^-1 s^-1 was established. Results are discussed with respect to the atm. chem. of fluorinated alcs.

Journal of Physical Chemistry A published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application In Synthesis of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kazakov, Andrei published the artcileComputational Design of New Refrigerant Fluids Based on Environmental, Safety, and Thermodynamic Characteristics, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Industrial & Engineering Chemistry Research (2012), 51(38), 12537-12548, database is CAplus.

We present a systematic search for new classes of refrigerants that would possess low values of global warming potential (GWP), along with low to moderate flammability and suitable thermodn. characteristics. We developed new methods for estimating, solely from the mol. structure, the radiative efficiency (RE, a measure of radiative climate forcing) and atm. lifetime; the combination of RE and lifetime yields an estimate of the GWP. We also developed an estimate of the lower flammability limit (LFL) based on the enthalpy of formation. These estimation techniques, along with a previously developed technique for estimating critical temperature (T_c), are applied to a library of over 56,000 candidate mols. We select fluids with GWP <200; 300 K < T_c <550 K; and LFL >0.1 Kg/m³. Filters for toxicity and chem. stability based on functional groups are also applied to arrive at 1234 candidates for further study. The candidates that would be suitable for use in present types of refrigeration equipment (those with critical temperatures <400 K) are dominated by halogenated alkenes; addnl. chem. classes, including halogenated ethers and cyclic compounds, are identified among fluids with higher critical temperatures

Industrial & Engineering Chemistry Research published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Priebbenow, Daniel L. published the artcileDiscovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines, Safety of 3,3,3-Trifluoropropan-1-ol, the publication is Journal of Medicinal Chemistry (2021), 64(7), 4150-4162, database is CAplus and MEDLINE.

Novel 3,3′-disubstituted-5,5′-bi(1,2,4-triazine) compounds with potent in vitro activity against Plasmodium falciparum parasites were recently discovered. To improve the pharmacokinetic properties of the triazine derivatives, a new structure-activity relationship (SAR) investigation was initiated with a focus on enhancing the metabolic stability of lead compounds These efforts led to the identification of second-generation highly potent antimalarial bis-triazines, exemplified by triazine 23(I), which exhibited significantly improved in vitro metabolic stability (8 and 42μL/min/mg protein in human and mouse liver microsomes). The disubstituted triazine dimer 23 was also observed to suppress parasitemia in the Peters 4-day test with a mean ED₅₀ value of 1.85 mg/kg/day and exhibited a fast-killing profile, revealing a new class of orally available antimalarial compounds of considerable interest.

Journal of Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mizukado, Junji published the artcileInsertion reactions of difluorocarbene generated by pyrolysis of hexafluoropropene oxide to OH bond, Application In Synthesis of 2240-88-2, the publication is Journal of Fluorine Chemistry (2005), 126(3), 365-369, database is CAplus.

ROCHF₂-type fluorinated ethers were synthesized by the reaction of hexafluoropropene oxide (HFPO) with alc. or phenol. In this reaction, although the insertion reaction of difluorocarbene to O-H bond and the nucleophilic attack of alc. or phenol to HFPO were competition, the insertion reaction proceeded predominantly to give fluorinated ether in the case of low nucleophilic alc. or phenol. In addition, high reaction pressure is advantageous to the selectivity of the fluorinated ethers in the reaction of HFPO with (CF₃)₂CHOH or C₆F₅OH.

Journal of Fluorine Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application In Synthesis of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mizukado, Junji published the artcileReactions of aliphatic fluoro-alcohols with CHClF₂ at atmospheric pressure, HPLC of Formula: 2240-88-2, the publication is Journal of Fluorine Chemistry (2006), 127(3), 400-404, database is CAplus.

The reactions of aliphatic fluoro-alcs. with chlorodifluoromethane (CHClF₂) at atm. pressure were examined In the reaction of CF₃CF₂CH₂OH, the difluoromethylated ether was obtained in moderate yield by using ethers such as 1,4-dioxane, diglyme, and THF, or their mixtures with water as a reaction solvent. While acetal and orthoformate were also produced, the selectivity of the difluoromethylated ether could be improved by adding water to the reaction. The effect of water could be explained by the reaction mechanism.

Journal of Fluorine Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, HPLC of Formula: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chang, Wei-chen published the artcileReaction of HppE with Substrate Analogues: Evidence for Carbon-Phosphorus Bond Cleavage by a Carbocation Rearrangement, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Journal of the American Chemical Society (2013), 135(22), 8153-8156, database is CAplus and MEDLINE.

(S)-2-Hydroxypropylphosphonic acid ((S)-2-HPP) epoxidase (HppE) is an unusual mononuclear non-heme iron enzyme that catalyzes the oxidative epoxidation of (S)-2-HPP in the biosynthesis of the antibiotic fosfomycin. Recently, HppE has been shown to accept (R)-1-hydroxypropylphosphonic acid as a substrate and convert it to an aldehyde product in a reaction involving a biol. unprecedented 1,2-phosphono migration. In this study, a series of substrate analogs were designed, synthesized, and used as mechanistic probes to study this novel enzymic transformation. The resulting data, together with insights obtained from d. functional theory calculations, are consistent with a mechanism of HppE-catalyzed phosphono group migration that involves the formation of a carbocation intermediate. As such, this reaction represents a new paradigm for biol. C-P bond cleavage.

Journal of the American Chemical Society published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jin, Jian published the artcileAlcohols as alkylating agents in heteroarene C-H functionalization, Computed Properties of 2240-88-2, the publication is Nature (London, United Kingdom) (2015), 525(7567), 87-90, database is CAplus and MEDLINE.

Primary alcs., diols containing at least one primary alc. moiety, and tetrahydrofurans acted as alkylating agents for six-membered nitrogen heterocycles such as isoquinolines, quinolines, and pyridines in the presence of an iridium photocatalyst Ir(ppy)₂(dtbbp)PF₆ (ppy = 1,2′-phenylpyridinediyl; dtbpy = 4,4′-di-tert-butyl-2,2-bipyridine), a thiol such as α-mercaptopropanoic acid, and p-toluenesulfonic acid in DMSO under blue LED light to yield alkylated heterocycles such as 1-methylisoquinoline in 43-98% yields. The medicinal agents fasudil dihydrochloride and milrinone were methylated and 3-phenylpropylated, resp., using this method in 82% and 43% yields. The method avoids the use of thermal conditions or stoichiometric oxidants. The mechanism was studied using fluorescence quenching experiments; the key step in the process is proposed to be the spin-center shift of a hydroxyalkylheteroaryl radical to yield an alkylheteroaryl radical with loss of water, precedented in biol. and synthetic settings. In the absence of a thiol, the radical generated from 1-isoquinolinemethanol coupled with two alkenes and two 1-pyrrolecarboxylates to yield dihydrobenzoisoquinolines and pyrrolylmethylisoquinolines, resp., in 25-65% yields.

Nature (London, United Kingdom) published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Computed Properties of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rueeger, Heinrich published the artcileDiscovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides, Related Products of alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2012), 55(7), 3364-3386, database is CAplus and MEDLINE.

Structure-based design of a series of cyclic hydroxyethylamine BACE1 inhibitors allowed the rational incorporation of prime- and nonprime-side fragments to a central core template without any amide functionality. The core scaffold selection and the structure-activity relationship development were supported by mol. modeling studies and by x-ray anal. of BACE1 complexes with various ligands to expedite the optimization of the series. The direct extension from P1-aryl- and heteroaryl moieties into the S3 binding pocket allowed the enhancement of potency and selectivity over cathepsin D. Restraining the design and synthesis of compounds to a physicochem. property space consistent with central nervous system drugs led to inhibitors with improved blood-brain barrier permeability. Guided by structure-based optimization, highly potent compounds were obtained, such as I, with enzymic and cellular IC₅₀ values of 2 and 50 nM, resp., and with >200-fold selectivity over cathepsin D. Pharmacodynamic studies in APP51/16 transgenic mice at oral doses of 180 μmol/kg demonstrated significant reduction of brain Aβ levels.

Journal of Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts