Category: 2240-88-2

Adding a certain compound to certain chemical reactions, such as: 2240-88-2, 3,3,3-Trifluoropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C3H5F3O, blongs to alcohols-buliding-blocks compound. Computed Properties of C3H5F3O

1.00 g (5.75 mmol) 2-bromo-5-hydroxypyridine, 0.66 g (5.75 mmol) 3,3,3-trifluoro-l- propanol and 1.51 g (5.75 mmol) triphenylphosphine are added to 50 mL THF. Then 1.32 g (5.75 mmol) di-tert-butyl azodicarboxylate are added and the reaction mixture is stirred at 60 °C for 3 h. The solvent is removed in vacuo and the crude product is purified by column chromatography (silica gel, PE/EtOAc). C8H7BrF3NO (M= 270.1 g/mol) ESI-MS: 270/272 [M+H]+ Rt (HPLC):0.94 min (method C)

The synthetic route of 2240-88-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen; WO2014/114578; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, molecular weight is 114.07, as common compound, the synthetic route is as follows.Application In Synthesis of 3,3,3-Trifluoropropan-1-ol

To a solution of 3,3,3-trifluoropropan-1-ol (5.0 g, 43.8 mmol) in CH2Cl2 (25 mL) and pyridine (25 mL) was added 4-(dimethylamino)pyridine (0.27 g, 2.2 mmol) followed by p-toluenesulfonyl chloride (8.4 g, 43.8 mmol). The mixture was allowed to stir at ambient temperature for 72 h then was quenched with 5percent aqueous HCl (20 mL). The layers were separated and the aqueous phase was extracted with CH2Cl2 (3.x.7 mL). The combined organic extracts were dried over Na2SO4, filtered, and concentrated under reduced pressure. Purification by column chromatography (SiO2, 75percent hexanes in EtOAc) afforded the title compound (8.0 g, 29.8 mmol, 68percent yield). MS (DCI/NH3) m/z 286 (M+NH4)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2240-88-2, 3,3,3-Trifluoropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; ABBOTT LABORATORIES; US2010/69348; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2240-88-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Example 19 3-[(4-Methoxyphenyl)amino]-4-phenyl-1-(3, 3, 3-TRIFLUOROPROPYL)-LH-PYRROLE-2, 5-dione To a solution of 3-[(4-methoxyphenyl)amino]-4-phenyl-1H-pyrrole-2, 5-dione (0.17 mmol, 50 mg), 3,3, 3-TRIFLUOROPROPAN-1-OL (0.19 mmol, 21 mg), diethyl azodicarboxylate (0.19 mmol, 33 mg) in dry THF (1 ML) was added triphenylphosphine (0.19 mmol, 49 mg) in dry THF (1 mL). The mixture was heated in a microwave reactor at 130°C for six min.. After cooling, the reaction mixture was purified by HPLC (95percent 0. 1M ammonium acetate buffer: 5percent CH3CN X 100percent CH3CN) to give 51 mg (77percent) of the title COMPOUND. 1H NMR (400 MHz, CDCl3) 8 7.27 (bs, 1H), 7.17-7. 06 (m, 3H), 7.00-6. 95 (m, 2H), 6.64-6. 55 (M, 4H), 3. 89 (t, J=7.3 Hz, 2H), 3.70 (s, 3H), 2.61-2. 48 (M, 2H).

According to the analysis of related databases, 2240-88-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; WO2005/5417; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, the common compound, a new synthetic route is introduced below. COA of Formula: C3H5F3O

Tert-butyl [(lr,4r)-6′-bromo-4-methoxy-5″-methyl-3’H-dispiro[cyclohexane-l,2′-indene- ,2″- imidazol]-4″-yl]carbamate (Intermediate 12, 715 mg, 1.50 mmol), allylpalladium(II) chloride (21.95 mg, 0.06 mmol), di-tert-butyl(2′,4′,6′-triisopropyl-3-methoxy-6-methylbiphenyl-2- yl)phosphine (70.3 mg, 0.15 mmol) and CS2CO3 (733 mg, 2.25 mmol) were placed in a MW- vial. Toluene (8 mL) was added and the head space was evacuated and refilled with argon. 3,3,3- Trifluoropropan-l-ol (684 mg, 6.00 mmol) was added and the mixture was heated to 100 C in a MW apparatus for 2 h. 2 M methanolic ammonia (8.57 mL, 60.0 mmol) and water (1.08 mL, 60.0 mmol) was added and the mixture was heated to 80 C for 12 h. The reaction mixture was cooled to r.t. The organic solvents were evaporated and the aqueous residue was extracted with DCM. The combined extracts were concentrated and the residue was purified by reverse phase preparative chromatography providing the title compound (410 mg, 67% yield). 1H MR (500 MHz, DMSO-de) delta 0.90 (td, 1 H), 1.08 – 1.27 (m, 2 H), 1.34 – 1.49 (m, 3 H), 1.80 (d, 2 H), 2.15 (s, 3 H), 2.69 (tt, 2 H), 2.82 – 2.99 (m, 3 H), 3.15 – 3.22 (m, 3 H), 4.00 – 4.10 (m, 2 H), 6.08 (d, 1 H), 6.51 (br. s., 2 H), 6.75 (dd, 1 H), 7.18 (d, 1 H); MS (APCI+) m/z 410 [M+H]+.

The synthetic route of 2240-88-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; KARLSTROeM, Sofia; CSJERNYIK, Gabor; SWAHN, Britt-Marie; SANDBERG, Lars; KOLMODIN, Karin; SOeDERMAN, Peter; OeHBERG, Liselotte; WO2013/190298; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2240-88-2, 3,3,3-Trifluoropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 3,3,3-Trifluoropropan-1-ol

Intermediate S-i A: 3,3,3 -Trifluoropropyl trifluoromethanesulfonate Intermediate S-i A: 3,3,3 -Trifluoropropyl trifluoromethanesulfonateOF?3o (S-iA)[00136j To a cold (-25 °C), stirred solution of 2,6-lutidine (18.38 mL, 158 mmol) in DCM (120 mL) was added Tf20 (24.88 mL, 147 mmol) over 3 mm, and the mixture wasstirred for 5 mm. To the reaction mixture was added 3,3,3-trifluoropropan-i-ol (12 g,105 mmol) over an interval of 3 mm. After 2 hr, the reaction mixture was warmed to room temperature and stirred for 1 hr. The reaction mixture was concentrated to half its volume, then purified by loading directly on a silica gel column (330g ISCO) and the product was eluted with DCM to afford Intermediate S-iA (13.74 g, 53percent) as a colorlessoil. ?H NMR (400 MHz, CDC13) oe ppm 4.71 (2 H, t, J=6.i5 Hz), 2.49-2.86 (2 H, m).

The synthetic route of 2240-88-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HAN, Wen-Ching; GILL, Patrice; GAVAI, Ashvinikumar, V.; QUESNELLE, Claude, A.; WO2014/47393; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C3H5F3O

Intermediate 31 3f3-trifluoropropoxy)methyl)pyrimidine To a solution of (2-chloro-6-(l-ethoxyvinyl)pyrimidin-4-yl)methyl methanesulfonate (0.452 g, 1.54 mmol) in benzene (7 mL) were added 3,3,3-trifluoropropan-l-ol (0.264 g, 2.32 mmol), sodium hydroxide (5 M, 0.463 mL, 2.32 mmol) and tetrabutylammonium hydrogen sulfate (0.052 g, 0.15 mmol). The mixture was stirred vigourously over night at room temperature. The mixture was filtered through a short silica plug with magnesium sulfate on top. The filter was washed with EtOAc. The mixture was purified by preparative HPLC to give 2-chloro-4-(l- ethoxyvinyl)-6-((3,3,3-trifluoropropoxy)methyl)pyrimidine 0.055 g 11 percent). MS (ES+) m/z 311 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 2240-88-2.

Reference:
Patent; ACTURUM LIFE SCIENCE AB; BESIDSKI, Yevgeni; YNGVE, Ulrika; PAULSEN, Kim; LINDE, Christian; MACSARI, Istvan; MALMBORG, Jonas; PAPTCHIKHINE, Alexander; ARVIDSSON, Per; WO2014/195323; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 3,3,3-Trifluoropropan-1-ol

Example 91 6-[5-Bromo-6-(3,3,3-trifluoro-propoxy)-pyridin-2-ylmethyl]-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-7-ylamine 6-(5-Bromo-6-fluoro-pyridin-2-ylmethyl)-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-7-ylamine (example 22) (45.0 mg, 0.13 mmol), 3,3,3-trifluoro-propan-1-ol (151.8 mg, 1.33 mmol)) and cesium carbonate (108.4 mg, 0.33 mmol) are dissolved in 1.0 mL of tetrahydrofuran. and stirred at 120¡ã C. for 15 minutes. The reaction mixture is concentrated under reduced pressure and the residue is purified by RP-HPLC (modifier: ammonium hydroxide). Yield: 36 mg (62percent of theory) HPLC (Method 5): Retention time=0.89 min.; m/z=431, 433 [M+H]+

With the rapid development of chemical substances, we look forward to future research findings about 2240-88-2.

Reference:
Patent; Boehringer Ingelheim International GmbH; GODBOUT, Cedrickx; TRIESELMANN, Thomas; VINTONYAK, Viktor; (84 pag.)US2018/37594; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 3,3,3-Trifluoropropan-1-ol

A solution of DIAD (0.743 mL, 3.82 mmol) in THF (2.00 mL) was added slowly to a solution of 4-fluoro-3-nitrophenol (500 mg, 3.18 mmol), 3,3,3-trifluoropropan-l-ol (0.310 mL, 3.50 mmol) and PPli3 (1.00 g, 3.82 mmol) in THF (10.0 mL). The resulting reaction mixture was allowed to stir at RT overnight, after which TLC (20percent EtOAc in Hex) and LC-MS analysis showed product formation. Reaction mixture was concentrated under reduced pressure and residue purified by flash column chromatography: silica gel with a gradient of 5-20percent EtOAc in Hex to afford l-fluoro-2-nitro-4-(3,3,3-trifluoropropoxy)benzene (322 mg, 40.0 percent yield) as a clear golden oil. NMR (400 MHz, DMSO-ifc) d 7.68 (dd, J= 6.0, 3.2 Hz, 1H), 7.54 (dd, J= 10.9, 9.2 Hz, 1H), 7.42 (dt, J = 9.3, 3.5 Hz, 1H), 4.31 (t, .7= 5.9 Hz, 2H), 2.8l (qt, /= 11.4, 5.9 Hz, 2H). 19F NMR (376 MHz, DMSO-ifc) d -63.06 (t, J= 11.2 Hz, 3F), -129.28 (ddd, J= 10.3, 6.0, 3.6 Hz, IF). LCMS RT (Method 2) = 3.491 min.

With the rapid development of chemical substances, we look forward to future research findings about 2240-88-2.

Reference:
Patent; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE; SOUTHALL, Noel T.; VON BERNHARDI, Rommy M.; ALVAREZ, Alejandra; DEXTRAS, Christopher R.; DULCEY, Andres E.; MARUGAN, Juan J.; ZANLUNGO, Silvana; TALLEY, Daniel C.; FERRER, Marc; HU, Xin; (0 pag.)WO2019/173761; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 2240-88-2

Under argon, 100mg (0.213 mmol) of 4-hydroxy-5,5-dimethyl-2-{2-methyl-8-[(2,3,6-trifluorobenzyl)oxy]imidazo[1 ,2-a]pyridin-3-yl}-5,7-dihydro-6H-pyrrolo[2,3-d] pyrimidin-6-one (Example 11), 26 mg (0.23 mmol) of 3,3,3-trifluoropropan-1-ol and 60 mg (0.23 mmol) of triphenylphosphine were suspended in 0.84 ml of THF, the mixture was mixed in an ultrasonic bath for 10 mm, 49 mg (0.230 mmol) of diisopropyl azodicarboxylate (DIAD) were then added and the mixture was stirred at RT overnight. A further 9 mg (0.08 mmol) of 3,3,3-trifluoropropan-1-ol, 20 mg (0.08 mmol) of triphenylphosphine and 15 mg (0.07 mmol) of diisopropyl azodicarboxylate were added, and the mixture was stirred at RT overnight. The reaction mixture was purified by preparative HPLC (RP-C1 8, mobile phase:acetonitrile/water gradient with addition of 0.05percent formic acid). This gave 48 mg (40percent of theory) of the target compound.11053] LC-MS (Method 1): R=1.04 mm11054] MS (ESIpos): mlz=566 [M+H]11055] ?H-NMR (400 MHz, DMSO-d5): oe [ppm]=1.34 (s, 6H), 2.76 (s, 3H), 2.83-2.95 (m, 2H), 4.69-4.75 (m, 2H),5.39 (s, 2H), 7.00-7.05 (m, 1H), 7.07-7.11 (m, 1H), 7.25-7.34 (m, 1H), 7.62-7.72 (m, 1H), 9.52 (dd, 1H), 11.36 (s, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 2240-88-2.

Reference:
Patent; Bayer Pharma Aktiengesellschaft; VAKALOPOULOS, Alexandros; GROMOV, Alexey; FOLLMANN, Markus; BROCKSCHNIEDER, Damian; STASCH, Johannes-Peter; MARQUARDT, Tobias; TERSTEEGEN, Adrian; WUNDER, Frank; REDLICH, Gorden; LANG, Dieter; LI, Volkhart Min-Jian; (95 pag.)US2016/347770; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 3,3,3-Trifluoropropan-1-ol

ert-butyl 3-hydroxypyrazole-1-carboxylate (2.03 g, 11.02 mmol), 3,3,3-trifluoropropan- 1-ol (approximately 1.320 g, 11.57 mmol), and triphenyl phosphine (approximately 3.189 g, 2.817 mL, 12.16 mmol) were combined in THF (20.40 mL) and the reaction was cooled in an ice bath. To the mixture was added DIAD (approximately 2.507 g, 2.441 mL, 12.40 mmol) dropwise and the reaction was allowed to warm to room temperature for 16 h. The mixture was evaporated and the resulting material was partitioned between ethyl acetate (50 mL) and 1N sodium hydroxide (50 mL). The organics were separated, washed with brine (30 mL), dried over sodium sulfate and evaporated. The crude material was purified by silica gel chromatography eluting with 0-30percent ethyl acetate in hexanes to give tert-butyl 3-(3,3,3-trifluoropropoxy)pyrazole-1- carboxylate (2.0 g, 65percent) ESI-MS m/z calc.280.1035, found 281.1 (M+1)+; Retention time: 0.62 minutes.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2240-88-2, 3,3,3-Trifluoropropan-1-ol.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; ABELA, Alexander, Russell; ALCACIO, Timothy; ANDERSON, Corey; ANGELL, Paul, Timothy; BAEK, Minson; CLEMENS, Jeremy, J.; CLEVELAND, Thomas; FERRIS, Lori, Ann; GROOTENHUIS, Peter Diederik, Jan; GROSS, Raymond, Stanley; GULEVICH, Anton; HADIDA RUAH, Sara, Sabina; HSIA, Clara, Kuang-Ju; HUGHES, Robert, M.; JOSHI, Pramod, Virupax; KANG, Ping; KESHAVARZ-SHOKRI, Ali; KHATUYA, Haripada; KRENITSKY, Paul, John; MCCARTNEY, Jason; MILLER, Mark, Thomas; PARASELLI, Prasuna; PIERRE, Fabrice Jean, Denis; SHI, Yi; SHRESTHA, Muna; SIESEL, David, Andrew; STAVROPOULOS, Kathy; TERMIN, Andreas, P.; UY, Johnny; VAN GOOR, Fredrick, F.; YOUNG, Tomothy, John; ZHOU, Jinglan; (398 pag.)WO2018/107100; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts