Category: 2240-88-2

Related Products of 2240-88-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2240-88-2 as follows.

b) Methyl 4-(benzyloxy)-3-(3,3,3-trifluoropropoxy)benzoateDiisopropyl azodicarboxylate (0.372 mL, 1.89 mmol) and triphenylphosphine (0.489 g, 1.86 mmol) were added to a solution of methyl 4-(benzyloxy)-3-hydroxybenzoate (0.355 g, 1.37 mmol) in tetrahydrofuran (20 mL) and the resulting reaction mixture was stirred for 55 min at room temperature. 3,3,3-Trifluoro-l-propanol (0.121 mL, 1.37 mmol) was added and the reaction mixture was stirred over night. The solvent was evaporated. Purification by column chromatography, using heptane/ethyl acetate (6:1) as the eluent, gave 0.162 g (33percent yield) of the title compound. GC MS (EI) m/z 354 [M]+*.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2240-88-2, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; BYLUND, Johan; EK, Maria, E; HOLENZ, Joerg; KERS, Annika; OeHBERG, Liselotte; WO2010/132016; (2010); A1;,
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Related Products of 2240-88-2, Adding some certain compound to certain chemical reactions, such as: 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol,molecular formula is C3H5F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2240-88-2.

c) Methyl 4-bromo-3-(3,3,3-trifluoropropoxy)benzoate3,3,3-Trifluoro-l-propanol (0.294 mL, 3.33 mmol) was added to a stirred solution of diisopropyl azodicarboxylate (1.21 mL, 6.15 mmol), triphenylphosphine (1.346 mL, 6.16 mmol) and methyl 4-bromo-3-hydroxybenzoate (0.9489 g, 4.11 mmol) in tetrahydrofuran (40 mL) and the mixture was stirred at room temperature for 2 days. Water and ethyl acetate was added and the aqueous phase was washed with ethyl acetate. The aqueous phase was acidified (pH~l) using hydrochloric acid (2 M) and extracted with ethyl acetate. The combined organic phases were washed with water and brine, dried over magnesium sulfate and the solvent was evaporated to give 0.894 g (67percent yield) of the title compound. 1H NMR (500 MHz, CDCl3) delta ppm 7.64 (d, 1 H) 7.53 – 7.58 (m, 2 H) 4.32 (t, 2 H) 3.94 (s, 3 H) 2.74 (dt, 2 H); GC MS (EI) m/z 326, 328 [M]+*.

According to the analysis of related databases, 2240-88-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; BYLUND, Johan; EK, Maria, E; HOLENZ, Joerg; KERS, Annika; OeHBERG, Liselotte; WO2010/132016; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2240-88-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Step 3; Preparation of tert-butyl 2-cvclopropyl-4-(3,3,3-trifluoropropoxy)-5,6,8,9- tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate; [057] 3,3,3-Trifluoropropan-1-ol (0.43 g, 3.7 mmol) was dissolved in 1 ,4-dioxane (5 mL). Potassium tert-butoxide (572 mg, 5.1 mmol) was added, and the mixture was stirred at rt for 15 min. tert-Butyl 4-chloro-2-cyclopropyl-5,6,8,9-tetrahydro-7H-pyrimido[4,5- EPO d]azepine-7-carboxylate (1.1 g, 3.4 mmol) was then added as a solution in 1 ,4-dioxane (5 ml_). The mixture was heated at 50°C overnight. The resulting white suspension was concentrated under reduced pressure, and the residue was partitioned between water and ethyl acetate. The organic layer was separated, dried (MgSO4), and concentrated under reduced pressure to give the title compound as a colorless oil (1.2 g, 94percent).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2240-88-2, 3,3,3-Trifluoropropan-1-ol.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2006/44762; (2006); A2;,
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Related Products of 2240-88-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, molecular weight is 114.07, as common compound, the synthetic route is as follows.

A mixture of Description 3 (100 mg, 0.325 mmol), 3,3,3-trifluoropropanol (74 mg, 0.649 mmol) and K2CO3 (134 mg, 0.974 mmol) in MeCN (3 mL) was stirred at 50 0C for 16 h. Additional 3,3,3- trifluoropropanol (30 mg) was added, the temperature raised to 60 0C and the reaction stirred for another 24 h. The reaction was condensed and partitioned between water and dichloromethane. The organic layer was dried over MgSO4 and evaporated. The crude product was purified firstly by preparative thin layer chromatography, eluting with 10 percent methanol in dichloromethane and then by flash column chromatography, eluting with ethyl acetate/dichloromethane [1:1] then ethyl acetate/dichloromethane/ methanol [50:47.5:2.5] to give the title compound (43 mg, 34 percent). 1H NMR (400 MHz, CDCl3) delta 7.67 (1 H, s), 7.45 (2 H, d, J8.6), 7.14 (2 H, d, J 8.7), 4.59 (2 H, t, J6.2), 4.16 (2 H, q, /7.3), 2.53-2.45 (2 H, m), 1.53 (3 H, m). M/z (ES+) 387, 389 (MH-H+).

The chemical industry reduces the impact on the environment during synthesis 2240-88-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2006/120481; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2240-88-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

methyl 6-hydroxypyrazolo[1,5-a]pyridine-3-carboxylate (0,100 g, 0.520 mmol), 3,3,3-trifluoropiOpan-l -ol (0.096 mL, 1.0 mmol), and l, -(azodicarbonyl)dipiperidine (0.394 g, 1.56 mmol) were placed in a pressure vial. Anhydrous toluene (5 mL) and tri-N-butylphosphine (0,390 mL, 1,56 mmol) were added, and the reaction mixture was stirred at 140 °C under microwave irradiation for 15 min. The reaction mixture was quenched by the addition of MeOH (1 mL), diluted with EtOAc (50 mL), Celite was added, and solvent was removed under reduced pressure. The residue was purified by ISCO (solid loading on Celite, 0-60percent EtOAc/DCM gradient) to give Intermediate 8 (0,064 g, 42 percent yield) as a white solid. MS (ESI) m/z; 289.0 (M+H)+. ‘H-NMR: (500 MHz, DMSO-d6) delta ppm 8.70 (d, 7=1.9 Hz, IH), 8.38 (s, IH), 7.98 (d, J=9.6 Hz, IH), 7.40 (dd, J=9.6, 2.2 Hz, 1H), 4.33 (t, J-5.9 Hz, 2H), 3.82 (s, 3H), 2.85 (qt, J=11.3, 5.8 Hz, 2H). 19F-NMR: (471 MHz, DMSO-d6) delta ppm -63.03 (s, 3F).

According to the analysis of related databases, 2240-88-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GLUNZ, Peter W.; LADZIATA, Vladimir; DE LUCCA, Indawati; TORA, George O.; MAISHAL, Tarun Kumar; TANGIRALA, Raghuram; THIYAGARAJAN, Kamalraj; (216 pag.)WO2019/14308; (2019); A1;,
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Reference of 2240-88-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Reference Example 74; methyl 4-(3,3,3-trifluoropropoxy)benzoate; [Show Image] 4-Methyl hydroxybenzoate (1.27 g), 3,3,3-trifluoro-1-propanol (1.14 g) and triphenylphosphine (2.63 g) were dissolved in tetrahydrofuran (35 mL), and the solution was cooled to 5°C. A solution of diisopropyl azodicarboxylate (2.25 g) in THF (5 mL) was added dropwise thereto over 10 min, and the mixture was stirred for 17 hr. The reaction mixture was allowed to warm to room temperature, and concentrated. The residue was purified by silica gel column chromatography [eluent; hexane:ethyl acetate=19:1–>3:1 (volume ratio)] to give the title compound (668 mg, yield 32percent) as a white solid. 1H NMR (300 MHz, CDCl3) delta: 2.65 (2 H, qt, J=10.5, 6.6 Hz), 3.89 (3 H, s), 4.25 (2 H, t, J=6.6 Hz), 6.92 (2 H, d, J=8.9 Hz), 8.00 (2 H, d, J=9.0 Hz).

According to the analysis of related databases, 2240-88-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2261213; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 2240-88-2, Adding some certain compound to certain chemical reactions, such as: 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol,molecular formula is C3H5F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2240-88-2.

Intermediate Example, 1-11Acid 30: 6-(3,3,3-Trifluoropropoxy)nicotinic acidTo a solution of potassium tert-butoxide (0.864 g, 7.7 mmol) in tetrahydrofuran (10 mL) 3,3,3-trifluoropropan-l-ol (0.878 g, 7.7 mmol) was added at 0 0C. After 5 min ethyl 6- chloronicotinate (1.3 g, 7.0 mmol) was added to the stirred solution. The mixture was allowed to reach ambient temperature and stirred for an additional 2 h. Brine was added and the mixture was extracted with ethyl acetate. The organic phase was dried over sodium sulfate, filtered and concentrated in vacuo. The residue (1.26 g, 4.8 mmol) was dissolved in a mixture of tetrahydrofuran (4 mL) and water (1 mL) and treated with lithium hydroxide (0.126 g, 3.0 mmol). The mixture was stirred at ambient temperature for 16 h and the tetrahydrofuran was removed in vacuo. Water (5 mL) was added and the pH adjusted to 2 with hydrochloric acid (4 M). The resulting precipitate was collected by filtration, washed with water and dried in vacuo to give 0.913 g (81percent yield) of the title compound: 1H NMR (DMSO-J6) delta 8.72 (d, 1 H), 8.16 (dd, 1 H), 6.91 (d, 1 H), 4.56 (t, 2 H), 2.81 (dd, 2 H); MS (ESI) m/z 236 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2240-88-2, 3,3,3-Trifluoropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; WO2008/130321; (2008); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 3,3,3-Trifluoropropan-1-ol

a){(R)-5,5-Difluoro-4-methyl-4-[3-(3,3,3-trifluoro-propoxy)-phenyl]-5,6-dihydro-4H-[1,3]oxazin-2-yl}-di(carbamic acid tert-butyl ester)A solution of [(R)-5,5-difluoro-4-(3-hydroxy-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-di(carbamic acid tert-butyl ester) (intermediate G3.1) (40 mg, 90.4 mumol), 3,3,3-trifluoropropan-1-ol (20.6 mg, 181 mumol), and triphenylphosphine (48.9 mg, 181 mumol) in tetrahydrofuran (1.2 ml) was treated dropwise with a solution of diethyl azodicarboxylate (40percent in toluene; 86.6 mg, 91.1 mul, 199 mumol) at room temperature over a period of 2 minutes.The mixture was stirred at room temperature for 20 hours.For the workup, the solvent was removed at reduced pressure, and the thus obtained residue was purified on a preparative silica gel TLC using a 4:1-mixture of heptane and ethyl acetate as the eluent.The {(R)-5,5-difluoro-4-methyl-4-[3-(3,3,3-trifluoro-propoxy)-phenyl]-5,6-dihydro-4H-[1,3]oxazin-2-yl}-di(carbamic acid tert-butyl ester) (8.3 mg, 17percent yield) was obtained as a light yellow oil. MS (ISP): m/z=539.4 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2240-88-2, 3,3,3-Trifluoropropan-1-ol.

Reference:
Patent; Hilpert, Hans; Narquizian, Robert; Pinard, Emmanuel; Polara, Alessandra; Rogers-Evans, Mark; Woltering, Thomas; Wostl, Wolfgang; US2012/295900; (2012); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. A new synthetic method of this compound is introduced below., Computed Properties of C3H5F3O

To 3,3,3-trifluoropropan-1-ol (19.9 mmol) in DMSO was added NaH (19.9 mmol). The mixture was allowed to stir at room temp under inert atmosphere for 1 h. Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate (3.0 g, 13.3 mmol) was added and the reaction was warmed to 100 °C until coupling was complete. After purification ethyl 6-(3,3,3-trifluoropropoxy)imidazo[1,2-b]pyridazine-3-carboxylate was obtained (1.2 g, 45percent). MS (ESI) calcd for C12H12F3N3O3: 303.08

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2240-88-2, 3,3,3-Trifluoropropan-1-ol.

Reference:
Patent; GlaxoSmithKline LLC; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; (583 pag.)EP2768509; (2017); B1;,
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Adding a certain compound to certain chemical reactions, such as: 2240-88-2, 3,3,3-Trifluoropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 2240-88-2, blongs to alcohols-buliding-blocks compound. Product Details of 2240-88-2

Step 5; Preparation of 2-cvclopropyl-9-methyl-4-(3.3,3-trifluoropropoxy)-6,7,8,9- tetrahvdro-5H-pyrimido[4,5-d]azepine dihvdrochloride; [073] To a solution of 3,3,3-trifluoropropan-1-ol (14 mg, 0.12 mmol) in 1 ,4-dioxane (1 ml.) was added potassium tert-butoxide (58 mg, 0.52 mmol), and the resulting mixture was stirred at rt for 15 min. tert-Butyl 4-chloro-2-cyclopropyl-9-methyl-5,6,8,9-tetrahydro- 7H-pyrimido[4,5-d]azepine-7-carboxylate (35 mg, 0.10 mmol) was then added, and the mixture was heated at 80°C overnight. The reaction was cooled to rt and filtered through a pad of Celite.(R).. The filtrate was concentrated under reduced pressure, and the crude material was re-dissolved in 1 ,4-dioxane. A 4M solution of hydrochloric acid in dioxane (0.1 ml_, 0.4 mmol) was added, and the mixture was stirred for 3 h. The dioxane solvent was removed under reduced pressure, and the crude residue was triturated with ethyl acetate to afford 12 mg (29percent) of desired product.

The synthetic route of 2240-88-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2006/44762; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts