Category: 2240-88-2

Adding a certain compound to certain chemical reactions, such as: 2240-88-2, 3,3,3-Trifluoropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

Example 114 2-[3-(2-Fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5,5-dimethyl-4-(3,3,3-trifluoropropoxy)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one Under argon, 57 mg (0.22 mmol) of triphenyl phosphine was dissolved in 1.5 ml THF, 43 mul (0.22 mmol) of diisopropyl azodicarboxylate and 25 mg (0.22 mmol) of 3,3,3-trifluoropropan-1-ol were added and it was stirred for 10 min. Then a suspension of 80 mg of example 109 in 0.5 ml DMF, which had been treated for 3 min in the ultrasonic bath, was added and the reaction mixture was stirred overnight at RT (solution). A further 57 mg (0.22 mmol) of triphenyl phosphine was added, the mixture was treated for 10 min in the ultrasonic bath, then a further 43 mul (0.22 mmol) of diisopropyl azodicarboxylate was added and it was stirred overnight. Then a further 25 mg (0.22 mmol) of 3,3,3-trifluoropropan-1-ol and 57 mg (0.22 mmol) of triphenyl phosphine were added, the reaction mixture was treated for 10 min in the ultrasonic bath, then 43 mul (0.22 mmol) of diisopropyl azodicarboxylate was added and it was stirred for another night at RT. The reaction mixture was purified by preparative HPLC (Reprosil C18, gradient of acetonitrile/0.01percent aq. formic acid). Yield: 37 mg (37percent of theor.) LC-MS (method 1): Rt=1.21 min; MS (ESIpos): m/z=501 [M+H]+ 1H-NMR (400 MHz, DMSO-d6): delta [ppm]=1.35 (s, 6H), 2.92 (qt, 2H), 4.79 (t, 2H), 5.87 (s, 2H), 7.11-7.27 (m, 3H), 7.32-7.41 (m, 1H), 7.45 (dd, 1H), 8.68 (dd, 1H), 8.86 (dd, 1H), 11.45 (s, 1H).

The synthetic route of 2240-88-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; FOLLMANN, Markus; STASCH, Johannes-Peter; REDLICH, Gorden; GRIEBENOW, Nils; LANG, Dieter; WUNDER, Frank; HUeBSCH, Walter; LINDNER, Niels; VAKALOPOULOS, Alexandros; TERSTEEGEN, Adrian; US2013/338137; (2013); A1;,
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Application of 2240-88-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, molecular weight is 114.07, as common compound, the synthetic route is as follows.

Example 98 (5a,8 )-8-Hydroxy-2-[4-(3,3,3-trifiuoro-propoxy)-phenyl]-2-aza-spiro[4.5]decan-l-oneStep 1: l-Nitro-4-(31313-trifluoro-propoxy)-benzeneTo a solution of a 3,3,3-trifiuoro-propan-l-ol (6.22 g) in acetonitrile (200 ml) kept at RT under an argon atmosphere were added l-fiuoro-4-nitro-benzene (10.1 g) and Cs2C03 (28.7 g) and the mixture was heated to 100°C for 18 h. The reaction mixture was cooled to RT and partitioned between AcOEt and ice water. The layers were separated, dried, over Na2S04 and the solvent was evaporated. The residue was purified by flash chromatography (silica gel; eluent: AcOEt/heptane: gradient 3 to 5 percent) to afford l-nitro-4-(3,3,3-trifiuoro- propoxy) -benzene as light yellow liquid (3.5 g). MS (EI, m/e): 235.0 (M+).

Statistics shows that 2240-88-2 is playing an increasingly important role. we look forward to future research findings about 3,3,3-Trifluoropropan-1-ol.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ACKERMANN, Jean; BRUGGER, Stephan; CONTE, Aurelia; HUNZIKER, Daniel; NEIDHART, Werner; NETTEKOVEN, Matthias; SCHULZ-GASCH, Tanja; WERTHEIMER, Stanley; WO2011/45292; (2011); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

To a dried round-bottom flask, 3,5-dimethylbenzoic acid (600 mg, 4.0 mmol) was dissolved inCH2Cl2 (14 mL) and a few drops of DMF was added. Oxalyl chloride (370 L, 4.4 mmol) wasadded dropwise resulting in gas evolution. The mixture was stirred for 30 min. 3,3,3-Trifluoropropan-1-ol (460 mg, 4.0 mmol), DMAP (10 mg, 0.080 mmol) and NEt3 (1.1 mL, 8.0mmol) were dissolved in CH2Cl2 (2.0 mL) and the CH2Cl2 solution was added to the reactionmixture. The mixture was stirred at ambient temperature overnight. To the resulting mixture, H2Owas added and extracted with Et2O three times. Combined organic extracts were washed with 1MNaOH aq., 1M HCl aq. and brine and dried over MgSO4. Concentrated mixture was purified byflash column chromatography (hexane/EtOAc = 100/1 to 20/1) to give the title compound(colorless oil, 703 mg, 71percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2240-88-2, 3,3,3-Trifluoropropan-1-ol.

Reference:
Article; Furukawa, Takayuki; Tobisu, Mamoru; Chatani, Naoto; Bulletin of the Chemical Society of Japan; vol. 90; 3; (2017); p. 332 – 342;,
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Reference of 2240-88-2, Adding some certain compound to certain chemical reactions, such as: 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol,molecular formula is C3H5F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2240-88-2.

(S)-tert-Butyl2-((5-fluoro-4-hydroxy-2-methoxybenzyl)carbamoyl)pyrrolidine-1-carboxylate ( 400 mg, 1.086 mmol, see example 1 ), triphenylphosphine (575 mg, 2.172mmol) and 3,3,3-trifluoropropan-1-ol (0.144 mL, 1.629 mmol) were dissolved in THF (12 mL) under inert atmosphere. The reaction mixture was cooled to -10°C and DIAD(0.444 mL, 2.172 mmol) was added dropwise via syringe and stirring at -1 0°C continuedfor 2h. Subsequently the cooling bath was removed and the reaction mixture stirredat room temperature over the weekend. Since the reaction was not complete, additionaltriphenylphosphine (575 mg, 2.172 mmol), 3,3,3-trifluoropropan-1-ol (0.144 mL, 1.629 mmol) and DIAD (0.444 mL, 2.172 mmol) were added to the reaction mixture at -5°Cand the reaction stirred at room temperature overnight. Since the reaction was still incomplete,once again DIAD (0.444 mL, 2.172 mmol) was added at -5°C and the reaction stirred at room temperature overnight. Water was added, the reaction mixture extractedthree times with ethyl acetate, the organic phases were combined and dried oversodium sulfate. Evaporation of the solvent and purification of the raw material by columnchromatography resulted in (S)-tert-butyl 2-((5-fluoro-2-methoxy-4-(3,3,3-trifluoropropoxy)benzyl)carbamoyl)pyrrolidine-1-carboxylate (180 mg; yield 37percent)BOC deprotection and subsequent salt formation was performed as described in example1 resulting in (2S)-N-[[5-fluoro-2-methoxy-4-(3,3,3-trifluoropropoxy)phenyl]methyl]pyrrolidine-2-carboxamide fumarate as white powder after lyophilization.LC-MS (M/Z [M+Ht): 365.2 1HNMR (500 MHz, methanol-d4) 8 7.03 (d, J= 11.5 Hz, 1H), 6.74 (d, J= 7.0 Hz, 1H),6.68 (s, 2H), 4.36, 4.31 (ABq, J = 14.8 Hz, 2H), 4.30 (t, J = 6.1 Hz, 2H), 4.23 (dd, J =8.4, 6.8 Hz, 1H), 3.85 (s, 3H), 3.39 (dt, J = 11.4, 7.0 Hz, 1H), 3.35- 3.27 (m, 1H), 2.76-2.63 (m, 2H), 2.45-2.34 (m, 1H), 2.08- 1.92 (m, 3H).

According to the analysis of related databases, 2240-88-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ABBVIE DEUTSCHLAND GMBH & CO. KG; ABBVIE INC.; BACKFISCH, Gisela; BAKKER, Margaretha; BLACK, Lawrence; BRAJE, Wilfried; DRESCHER, Karla; ERHARD, Thomas; HAUPT, Andreas; HOFT, Carolin; KLING, Andreas; LAKIS, Viktor; MACK, Helmut; RELO, Ana Lucia; (111 pag.)WO2018/175449; (2018); A1;,
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Synthetic Route of 2240-88-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. A new synthetic method of this compound is introduced below.

To the solution of 2.00 g Preparation 9a3 (8.61 mmol) in acetonitrile 2.38 g K2C03 (17.2 mmol), then 3,3,3-trifluoropropan-1-ol were added and the so obtained mixture was stirred for I Oh at 60°C. The reaction mixture was cooled, filtered and the filtrate concentratedunder reduced pressure. The residue was purified via flash chromatography using heptane and ethyl-acetate as eluents to give 4-(dimethoxymethyl)-2-(3,3,3-trifluoropropoxy) pyrimidine.?11 NMR (400 MHz, DMSO-d6): 8.68 (d, 111), 7.22 (d, 111), 5.22 (s, 111), 4.53 (t, 211), 3.33 (s, 611), 2.83 (m, 211).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2240-88-2, 3,3,3-Trifluoropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; KOTSCHY, Andras; SZLAVIK, Zoltan; CSEKEI, Marton; PACZAL, Attila; SZABO, Zoltan; SIPOS, Szabolcs; RADICS, Gabor; PROSZENYAK, Agnes; BALINT, Balazs; BRUNO, Alain; GENESTE, Olivier; DAVIDSON, James Edward Paul; MURRAY, James Brooke; CHEN, I-Jen; PERRON-SIERRA, Francoise; WO2015/97123; (2015); A1;,
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