Category: 2240-88-2

Application of 2240-88-2On November 3, 2020 ,《Photochemical O-H Functionalization Reactions of Cyclic Diazoamides》 appeared in Advanced Synthesis & Catalysis. The author of the article were Empel, Claire; Verspeek, Dennis; Jana, Sripati; Koenigs, Rene M.. The article conveys some information:

Herein, the photochem. O-H functionalization reaction of acidic alcs. with cyclic diazoamides were described. The O-H functionalization reaction of different fluorinated and non-fluorinated alcs. to give the corresponding ether products in high yields (43 examples, up to 97% yield) were studied. Furthermore, the evaluation of photoexcited proton transfer reaction pathway in comparison to classic carbene transfer reactions were performed. The results came from multiple reactions, including the reaction of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Application of 2240-88-2)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Application of 2240-88-2

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Alcohols – Chemistry LibreTexts

Zhang, Zhuming; Ghosh, Avijit; Connolly, Peter J.; King, Peter; Wilde, Thomas; Wang, Jianyao; Dong, Yawei; Li, Xueliang; Liao, Daohong; Chen, Hao; Tian, Gaochao; Suarez, Javier; Bonnette, William G.; Pande, Vineet; Diloreto, Karen A.; Shi, Yifan; Patel, Shefali; Pietrak, Beth; Szewczuk, Lawrence; Sensenhauser, Carlo; Dallas, Shannon; Edwards, James P.; Bachman, Kurtis E.; Evans, David C. published their research in Journal of Medicinal Chemistry on August 12 ,2021. The article was titled 《Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer》.Computed Properties of C3H5F3O The article contains the following contents:

Selective cyclooxygenase (COX)-2 inhibitors have been extensively studied for colorectal cancer (CRC) chemoprevention. Celecoxib has been reported to reduce the incidence of colorectal adenomas and CRC but is also associated with an increased risk of cardiovascular events. Here, we report a series of gut-restricted, selective COX-2 inhibitors characterized by high colonic exposure and minimized systemic exposure. By establishing acute ex vivo 18F-FDG uptake attenuation as an efficacy proxy, we identified a subset of analogs that demonstrated statistically significant in vivo dose-dependent inhibition of adenoma progression and survival extension in an APCmin/+ mouse model. However, in vitro-in vivo correlation anal. showed their chemoprotective effects were driven by residual systemic COX-2 inhibition, rationalizing their less than expected efficacies and highlighting the challenges associated with COX-2-mediated CRC disease chemoprevention. In addition to this study using 3,3,3-Trifluoropropan-1-ol, there are many other studies that have used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Computed Properties of C3H5F3O) was used in this study.

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Computed Properties of C3H5F3O

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Zhang, Chun-Hui; Spasov, Krasimir A.; Reilly, Raquel A.; Hollander, Klarissa; Stone, Elizabeth A.; Ippolito, Joseph A.; Liosi, Maria-Elena; Deshmukh, Maya G.; Tirado-Rives, Julian; Zhang, Shuo; Liang, Zhuobin; Miller, Scott J.; Isaacs, Farren; Lindenbach, Brett D.; Anderson, Karen S.; Jorgensen, William L. published their research in ACS Medicinal Chemistry Letters on August 12 ,2021. The article was titled 《Optimization of triarylpyridinone inhibitors of the main protease of SARS-CoV-2 to low-nanomolar antiviral potency》.Safety of 3,3,3-Trifluoropropan-1-ol The article contains the following contents:

Non-covalent inhibitors of the main protease (Mpro) of SARS-CoV-2 having a pyridinone core were previously reported with IC50 values as low as 0.018μM for inhibition of enzymic activity and EC50 values as low as 0.8μM for inhibition of viral replication in Vero E6 cells. The series has now been further advanced by consideration of placement of substituted five-membered-ring heterocycles in the S4 pocket of Mpro and N-methylation of a uracil ring. Free energy perturbation calculations provided guidance on the choice of the heterocycles, and protein crystallog. confirmed the desired S4 placement. Here we report inhibitors with EC50 values as low as 0.080μM, while remdesivir yields values of 0.5-2μM in side-by-side testing with infectious SARS-CoV-2. A key factor in the improvement is enhanced cell permeability, as reflected in PAMPA measurements. Compounds 19 (I) and 21 (II) are particularly promising as potential therapies for COVID-19, featuring IC50 values of 0.044-0.061μM, EC50 values of ca. 0.1μM, good aqueous solubility, and no cytotoxicity. The experimental process involved the reaction of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Safety of 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Safety of 3,3,3-Trifluoropropan-1-ol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of 3,3,3-Trifluoropropan-1-olOn March 12, 2020, Pettus, Liping H.; Bourbeau, Matthew P.; Bradley, Jodi; Bartberger, Michael D.; Chen, Kui; Hickman, Dean; Johnson, Michael; Liu, Qingyian; Manning, James R.; Nanez, Adrian; Siegmund, Aaron C.; Wen, Paul H.; Whittington, Douglas A.; Allen, Jennifer R.; Wood, Stephen published an article in Journal of Medicinal Chemistry. The article was 《Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2》. The article mentions the following:

β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is an aspartyl protease that plays a key role in the production of amyloid β (Aβ) in the brain and has been extensively pursued as a target for the treatment of Alzheimer’s disease (AD). BACE2, an aspartyl protease that is structurally related to BACE1, has been recently reported to be involved in melanosome maturation and pigmentation. Herein, we describe the development of a series of cyclopropylthiazines as potent and orally efficacious BACE1 inhibitors. Lead optimization led to the identification of 20, a mol. with biochem. IC50 BACE2/BACE1 ratio of 47. Administration of 20 resulted in no skin/fur color change in a 13-day mouse hypopigmentation study and demonstrated robust and sustained reduction of CSF and brain Aβ40 levels in rat and monkey pharmacodynamic models. On the basis of a compelling data package, 20 (AM-6494) was advanced to preclin. development. The experimental process involved the reaction of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Application In Synthesis of 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Application In Synthesis of 3,3,3-Trifluoropropan-1-ol

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Application In Synthesis of 3,3,3-Trifluoropropan-1-olOn November 11, 2021 ,《DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis》 appeared in Journal of Medicinal Chemistry. The author of the article were Mowbray, Charles E.; Braillard, Stephanie; Glossop, Paul A.; Whitlock, Gavin A.; Jacobs, Robert T.; Speake, Jason; Pandi, Bharathi; Nare, Bakela; Maes, Louis; Yardley, Vanessa; Freund, Yvonne; Wall, Richard J.; Carvalho, Sandra; Bello, Davide; Van den Kerkhof, Magali; Caljon, Guy; Gilbert, Ian H.; Corpas-Lopez, Victoriano; Lukac, Iva; Patterson, Stephen; Zuccotto, Fabio; Wyllie, Susan. The article conveys some information:

Visceral leishmaniasis (VL) is a parasitic disease endemic across multiple regions of the world and is fatal if untreated. Current therapies are unsuitable, and there is an urgent need for safe, short-course, and low-cost oral treatments to combat this neglected disease. The benzoxaborole chemotype has previously delivered clin. candidates for the treatment of other parasitic diseases. Here, we describe the development and optimization of this series, leading to the identification of compounds with potent in vitro and in vivo antileishmanial activity. The lead compound (DNDI-6148) combines impressive in vivo efficacy (>98% reduction in parasite burden) with pharmaceutical properties suitable for onward development and an acceptable safety profile. Detailed mode of action studies confirm that DNDI-6148 acts principally through the inhibition of Leishmania cleavage and polyadenylation specificity factor (CPSF3) endonuclease. As a result of these studies and its promising profile, DNDI-6148 has been declared a preclin. candidate for the treatment of VL. The experimental process involved the reaction of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Application In Synthesis of 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Application In Synthesis of 3,3,3-Trifluoropropan-1-ol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of 3,3,3-Trifluoropropan-1-olOn November 15, 2021 ,《Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms》 appeared in European Journal of Medicinal Chemistry. The author of the article were Yu, Jia-Hui; Xu, Xiao-Fang; Hou, Wen; Meng, Ying; Huang, Mei-Yan; Lin, Jing; Chen, Wei-Min. The article conveys some information:

The Staphylococcus aureus can switch to a transient genotype-invariant dormancy, known as a persister, to survive treatment with high doses of antibiotics. This transient persister is an important reason underlying its resistance. There is an urgent need to find new antibacterial agents capable of eradicating methicillin-resistant S. aureus (MRSA) persisters. In this study, 37 new derivatives of cajaninstilbene acid (CSA) were designed and synthesized, and their biol. activity against MRSA persisters was evaluated. Most of the newly synthesized derivatives exhibit more potent antimicrobial properties against S. aureus and MRSA than CSA itself, and 23 of the 37 derivatives show a tendency to eradicate MRSA persisters. A representative compound, I, was demonstrated to target bacterial cell membranes. It eradicated the adherent biofilm of MRSA in a concentration dependent manner, and showed a synergistic antibacterial effect with piperacilin. In a model mouse abscess caused by MRSA persisters, I effectively reduced the bacterial load in vivo. These results indicate that I is a potential candidate for treatment of MRSA persister infections. In the experiment, the researchers used many compounds, for example, 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Safety of 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Safety of 3,3,3-Trifluoropropan-1-ol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines》 was written by Priebbenow, Daniel L.; Mathiew, Mitch; Shi, Da-Hua; Harjani, Jitendra R.; Beveridge, Julia G.; Chavchich, Marina; Edstein, Michael D.; Duffy, Sandra; Avery, Vicky M.; Jacobs, Robert T.; Brand, Stephen; Shackleford, David M.; Wang, Wen; Zhong, Longjin; Lee, Given; Tay, Erin; Barker, Helena; Crighton, Elly; White, Karen L.; Charman, Susan A.; De Paoli, Amanda; Creek, Darren J.; Baell, Jonathan B.. Category: alcohols-buliding-blocks And the article was included in Journal of Medicinal Chemistry on April 8 ,2021. The article conveys some information:

Novel 3,3′-disubstituted-5,5′-bi(1,2,4-triazine) compounds with potent in vitro activity against Plasmodium falciparum parasites were recently discovered. To improve the pharmacokinetic properties of the triazine derivatives, a new structure-activity relationship (SAR) investigation was initiated with a focus on enhancing the metabolic stability of lead compounds These efforts led to the identification of second-generation highly potent antimalarial bis-triazines, exemplified by triazine 23(I), which exhibited significantly improved in vitro metabolic stability (8 and 42μL/min/mg protein in human and mouse liver microsomes). The disubstituted triazine dimer 23 was also observed to suppress parasitemia in the Peters 4-day test with a mean ED50 value of 1.85 mg/kg/day and exhibited a fast-killing profile, revealing a new class of orally available antimalarial compounds of considerable interest. The results came from multiple reactions, including the reaction of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Category: alcohols-buliding-blocks)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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《Descriptors for fluorotelomere alcohols. Calculation of physicochemical properties》 was written by Abraham, Michael H.; Acree, William E.. Recommanded Product: 3,3,3-Trifluoropropan-1-ol And the article was included in Physics and Chemistry of Liquids in 2021. The article conveys some information:

Abraham model solute descriptors are calculated for several environmentally important fluorotelomer alcs. from published partition coefficient and solubility data. The various descriptors all show a gradual trend from 1:2FTOH to 8:2FTOH. The maximum deviation from self-consistent values is 0.19 log units in the calculations on vapor pressure (concentration in air) and solubility in water (concentration in water). In the experimental materials used by the author, we found 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Recommanded Product: 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Recommanded Product: 3,3,3-Trifluoropropan-1-ol

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In 2022,Physical Chemistry Chemical Physics included an article by Shinkai, Takahiro; Hsu, Po-Jen; Fujii, Asuka; Kuo, Jer-Lai. Formula: C3H5F3O. The article was titled 《Infrared spectroscopy and theoretical structure analyses of protonated fluoroalcohol clusters: the impact of fluorination on the hydrogen bond networks》. The information in the text is summarized as follows:

To explore the impact of fluorination on the hydrogen bond networks of protonated alkylalcs., IR spectroscopy and theor. computations of protonated 2,2,2-trifluoroethanol clusters, H+(TFE)n, (n = 4-7), were performed. It has been demonstrated that the development of the hydrogen bond networks from a linear type to cyclic types occurs in this size region for the protonated alkylalc. clusters. In contrast, IR spectroscopy of H+(TFE)n in the OH/CH stretch region clearly indicated that the linear type structures are held in the whole size range, irresp. of temperature of the clusters. The extensive stable isomer structure search of H+(TFE)n based on our latest sampling approach supported the strong preference of the linear type hydrogen bond networks. Detailed analyses of the free OH stretching vibrational bands evidenced the intra- and intermol. OH···FC interactions in the clusters. In addition, IR spectra of protonated clusters of 2,2-difluoroethanol, 2,2-difluoropropanol, and 3,3,3-trifluoropropanol were measured for n = 4 and 5, and their spectra also indicated the effective inhibition of the cyclic hydrogen bond network formation by the fluorination.3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Formula: C3H5F3O) was used in this study.

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Formula: C3H5F3O

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Alcohol – Wikipedia,
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The author of 《Photoinduced Proton-Transfer Reactions for Mild O-H Functionalization of Unreactive Alcohols》 were Jana, Sripati; Yang, Zhen; Li, Fang; Empel, Claire; Ho, Junming; Koenigs, Rene M.. And the article was published in Angewandte Chemie, International Edition in 2020. Safety of 3,3,3-Trifluoropropan-1-ol The author mentioned the following in the article:

Hexafluoroisopropanol is typically considered as an unreactive solvent and not as a reagent in organic synthesis. Herein, we report on a mild and efficient photochem. reaction of aryl diazoacetates with hexafluoroisopropanol that enables, under stoichiometric reaction conditions, the synthesis of fluorinated ethers in excellent yield. Mechanistic studies indicate there is a preorganization of hexafluoroisopropanol and the diazoalkane acts as an unreactive hydrogen-bonding complex. Only after photoexcitation does this complex undergo a protonation-substitution reaction to the reaction product. Investigations on the applicability of this photochem. transformation show that a broad variety of acidic alcs. can be subjected to this transformation and thus demonstrate the feasibility of this concept for O-H functionalization reactions (54 examples, up to 98% yield). In the experimental materials used by the author, we found 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Safety of 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Safety of 3,3,3-Trifluoropropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts