Category: 2240-88-2

《19F magnetic resonance imaging enabled real-time, non-invasive and precise localization and quantification of the degradation rate of hydrogel scaffolds in vivo》 was published in Biomaterials Science in 2020. These research results belong to Li, Qinghua; Feng, Zujian; Song, Huijuan; Zhang, Jianhua; Dong, Anjie; Kong, Deling; Wang, Weiwei; Huang, Pingsheng. COA of Formula: C3H5F3O The article mentions the following:

The degradation behavior of hydrogel scaffolds is closely related to the controlled release of bioactive agents and matching with the proliferative demands of newly generated tissues. Here, for the first time, we presented the use of 19F magnetic resonance imaging (19F MRI) to precisely monitor the localization and quantify the degradation rate of implantable or injectable hydrogels in a real-time and noninvasive manner, with no interference of endogenous background signals and limitation of penetration depth. The total voxel and content in the region of interest (ROI) were linearly correlated to the injection amount, providing exact 3D stereoscopic and 2D anatomical information in the meantime. Moreover, a computational algorithm was established to present the real-time degradation rate in vivo as a function of time, which was implemented directly from the 19F MRI dataset. In addition, labeling with a zwitterionic 19F contrast agent demonstrated a facile and general applicability for multiple types of materials with no influence on their original gelation properties as well as 19F NMR properties in the hydrogel matrix. Therefore, this 19F MRI method offers a new approach to non-invasively track the degradation rate of hydrogel scaffolds in vivo in a precise localization and accurate quantification way, which will suffice the need for the evaluation of implants at deep depths in large animals or human objects. In addition to this study using 3,3,3-Trifluoropropan-1-ol, there are many other studies that have used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2COA of Formula: C3H5F3O) was used in this study.

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Related Products of 2240-88-2On March 1, 2021, Woelke, Christian; Diddens, Diddo; Heidrich, Bastian; Winter, Martin; Cekic-Laskovic, Isidora published an article in ChemElectroChem. The article was 《Understanding the Effectiveness of Phospholane Electrolyte Additives in Lithium-Ion Batteries under High-Voltage Conditions》. The article mentions the following:

Six phospholane functional electrolyte additives that enable the formation of an effective cathode electrolyte interphase (CEI) via a polymerization reaction on the electrode surface were designed, synthesized, and comparatively analyzed by means of complementary exptl. and computational methods in order to understand their mode of action in NMC111||graphite battery cells under high voltage conditions. Two reaction mechanisms, namely a phosphate-based and a phosphonate-based mechanism, were postulated and, based on systematic anal., the phosphate mechanism was identified as the more likely. Direct correlation of the phospholane’s structural features and relevant properties impacting the direct correlation of the phospholane’s structural features and relevant properties impacting the overall cycling performance of NMC111||graphite cells, as depicted by capacity retention, stands for a vital example approach towards identifying promising electrolyte components for advanced, targeted applications. In the experiment, the researchers used many compounds, for example, 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Related Products of 2240-88-2)

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Computed Properties of C3H5F3OOn March 24, 2021, Zhang, Chun-Hui; Stone, Elizabeth A.; Deshmukh, Maya; Ippolito, Joseph A.; Ghahremanpour, Mohammad M.; Tirado-Rives, Julian; Spasov, Krasimir A.; Zhang, Shuo; Takeo, Yuka; Kudalkar, Shalley N.; Liang, Zhuobin; Isaacs, Farren; Lindenbach, Brett; Miller, Scott J.; Anderson, Karen S.; Jorgensen, William L. published an article in ACS Central Science. The article was 《Potent noncovalent inhibitors of the main protease of SARS-CoV-2 from molecular sculpting of the drug perampanel guided by free energy perturbation calculations》. The article mentions the following:

Starting from our previous finding of 14 known drugs as inhibitors of the main protease (Mpro) of SARS-CoV-2, the virus responsible for COVID-19, we have redesigned the weak hit perampanel to yield multiple noncovalent, nonpeptidic inhibitors with ca. 20 nM IC50 values in a kinetic assay. Free-energy perturbation (FEP) calculations for Mpro-ligand complexes provided valuable guidance on beneficial modifications that rapidly delivered the potent analogs. The design efforts were confirmed and augmented by determination of high-resolution X-ray crystal structures for five analogs bound to Mpro. Results of cell-based antiviral assays further demonstrated the potential of the compounds for treatment of COVID-19. In addition to the possible therapeutic significance, the work clearly demonstrates the power of computational chem. for drug discovery, especially FEP-guided lead optimization. The experimental part of the paper was very detailed, including the reaction process of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Computed Properties of C3H5F3O)

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In 2021,IOSR Journal of Pharmacy included an article by Yadav, B. P.; Joshi, Ajit; Thakur, Meenakshi. Name: 3,3,3-Trifluoropropan-1-ol. The article was titled 《Synthesis of some novel pyrimidine derivatives and compared to available antimicrobial (MTCC inhibitors) drugs》. The information in the text is summarized as follows:

A new series of pyrimidine derivatives I (R1 = trifluoromethyl, Cl; R2 = Me, Et, i-Pr) have been synthesized by reacting substituted pyrimidine carboxylic acids II with 3-methoxyaniline, de-methylation using BBr3 to form hydroxy derivatives, which were then alkylated with resp. alkyl halides R2I to synthesize substituted pyrimidine derivatives I. The synthesized compounds I were screened for their in vitro growth inhibiting activity against different strains. After reading the article, we found that the author used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Name: 3,3,3-Trifluoropropan-1-ol)

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Le, Thuy G.; Kundu, Abhijit; Ghoshal, Atanu; Nguyen, Nghi H.; Preston, Sarah; Jiao, Yaqing; Ruan, Banfeng; Xue, Lian; Huang, Fei; Keiser, Jennifer; Hofmann, Andreas; Chang, Bill C. H.; Garcia-Bustos, Jose; Wells, Timothy N. C.; Palmer, Michael J.; Jabbar, Abdul; Gasser, Robin B.; Baell, Jonathan B. published an article on January 24 ,2019. The article was titled 《Structure-activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of Haemonchus contortus development》, and you may find the article in Journal of Medicinal Chemistry.SDS of cas: 2240-88-2 The information in the text is summarized as follows:

Recently, we have discovered that the registered pesticide, tolfenpyrad, unexpectedly and potently inhibits the development of the L4 larval stage of the parasitic nematode Haemonchus contortus with an IC50 value of 0.03 μM while displaying good selectivity, with an IC50 of 37.9 μM for cytotoxicity. As a promising mol. template for medicinal chem. optimization, we undertook anthelmintic structure-activity relationships for this chem. Modifications of the left-hand side (LHS), right-hand side (RHS), and middle section of the scaffold were explored to produce a set of 57 analogs. Analogs I, II, and III were shown to be the most potent compounds of the series, with IC50 values at a subnanomolar level of potency against the chemotherapeutically relevant fourth larval (L4) stage of H. contortus. Selected compounds from the series also showed promising activity against a panel of other different parasitic nematodes, such as hookworms and whipworms. In the part of experimental materials, we found many familiar compounds, such as 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2SDS of cas: 2240-88-2)

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HPLC of Formula: 2240-88-2On October 14, 2021 ,《Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders》 was published in Journal of Medicinal Chemistry. The article was written by Turdi, Huji; Chao, Hannguang; Hangeland, Jon J.; Ahmad, Saleem; Meng, Wei; Brigance, Robert; Zhao, Guohua; Wang, Wei; Moore, Fang; Ye, Xiang-Yang; Mathur, Arvind; Hou, Xiaoping; Kempson, James; Wu, Dauh-Rurng; Li, Yi-Xin; Azzara, Anthony V.; Ma, Zhengping; Chu, Ching-Hsuen; Chen, Luping; Cullen, Mary Jane; Rooney, Suzanne; Harvey, Susan; Kopcho, Lisa; Panemangelor, Reshma; Abell, Lynn; O′Malley, Kevin; Keim, William J.; Dierks, Elizabeth; Chang, Shu; Foster, Kimberly; Apedo, Atsu; Harden, David; Dabros, Marta; Gao, Qi; Pelleymounter, Mary Ann; Whaley, Jean M.; Robl, Jeffrey A.; Cheng, Dong; Lawrence, R. Michael; Devasthale, Pratik. The article contains the following contents:

MGAT2 inhibition is a potential therapeutic approach for the treatment of metabolic disorders. High-throughput screening of the BMS internal compound collection identified the aryl dihydropyridinone compound 1 (hMGAT2 IC50 = 175 nM) as a hit. Compound 1 had moderate potency against human MGAT2, was inactive vs mouse MGAT2 and had poor microsomal metabolic stability. A novel chem. route was developed to synthesize aryl dihydropyridinone analogs to explore structure-activity relationship around this hit, leading to the discovery of potent and selective MGAT2 inhibitors 21f, 21s, and 28e that are stable to liver microsomal metabolism After triaging out 21f due to its inferior in vivo potency, pharmacokinetics, and structure-based liabilities and tetrazole 28e due to its inferior channel liability profile, 21s (BMS-963272) was selected as the clin. candidate following demonstration of on-target weight loss efficacy in the diet-induced obese mouse model and an acceptable safety and tolerability profile in multiple preclin. species. After reading the article, we found that the author used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2HPLC of Formula: 2240-88-2)

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《C(sp2)-H/O-H cross-dehydrogenative coupling of quinoxalin-2(1H)-ones with alcohols under visible-light photoredox catalysis》 was written by Xie, Long-Yong; Liu, Yi-Shu; Ding, Hong-Ru; Gong, Shao-Feng; Tan, Jia-Xi; He, Jun-Yi; Cao, Zhong; He, Wei-Min. Related Products of 2240-88-2 And the article was included in Chinese Journal of Catalysis on August 31 ,2020. The article conveys some information:

An efficient and practical route to various 3-alkoxylquinoxalin-2(1H)-ones through visible-light photocatalytic C(sp2)-H/O-H cross-dehydrogenation coupling of quinoxalin-2(1H)-ones and alcs. by employing ambient air as an oxidant at room temperature under metal-free conditions was developed. In the experiment, the researchers used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Related Products of 2240-88-2)

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《Palladium-Catalyzed Para-Selective Difluoromethylation of Arene Esters》 was written by Tu, Guangliang; Wang, Dongjie; Yuan, Chunchen; Zhang, Jingyu; Zhao, Yingsheng. Product Details of 2240-88-2 And the article was included in Journal of Organic Chemistry on August 21 ,2020. The article conveys some information:

Highly efficient, palladium-catalyzed, para-selective difluoromethylation of arene esters has been developed using [1,1′-biphenyl-2-yl]dicyclohexylphosphine as the effective ligand. A wide variety of arene esters bearing various functional groups were all compatible with the reaction conditions, leading to para-difluoromethylated products in moderate to good yields. Moreover, benzamide and benzenesulfonamide were also well-tolerated, suggesting that this novel catalyst system has broad applications to a variety of substrates. The experimental process involved the reaction of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Product Details of 2240-88-2)

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Hashimoto, Yuka; Hosokawa, Sasuga; Liang, Fengying; Suzuki, Yuto; Dai, Namin; Tana, Gegen; Eda, Kazuo; Kakiuchi, Toshifumi; Okazoe, Takashi; Harada, Hidefumi; Tsuda, Akihiko published an article in Journal of Organic Chemistry. The title of the article was 《Photo-on-Demand Base-Catalyzed Phosgenation Reactions with Chloroform: Synthesis of Arylcarbonate and Halocarbonate Esters》.Recommanded Product: 3,3,3-Trifluoropropan-1-ol The author mentioned the following in the article:

Carbonate esters are utilized as solvents and reagents for C1 building blocks in organic synthesis. This study reports a novel photo-on-demand in situ synthesis of carbonate esters with CHCl3 solutions containing a mixture of an aromatic or haloalkyl alc. having relatively high acidity, and an organic base. We found that the acid-base interaction of the alc. and base in the CHCl3 solution plays a key role in enabling the photochem. reaction. This reaction allows practical syntheses of di-Ph carbonate derivatives, haloalkyl carbonates, and polycarbonates, which are important chems. and materials in industry. After reading the article, we found that the author used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Recommanded Product: 3,3,3-Trifluoropropan-1-ol)

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COA of Formula: C3H5F3OOn March 10, 2022, Empel, Claire; Pei, Chao; He, Feifei; Jana, Sripati; Koenigs, Rene M. published an article in Chemistry – A European Journal. The article was 《Proton or Carbene Transfer? On the Dark and Light Reaction of Diazoalkanes with Alcohols》. The article mentions the following:

A fundamental understanding of the reaction of diazoalkanes with alcs. to made this transformation amenable to a generalized approach towards formal alkylation reactions of alcs. with diazoalkanes was aimed. Exptl. and theor. studies suggested a direct proton transfer only in exceptional cases. In a more general setting, such O-H functionalization proceeded both under dark and photochem. conditions via a key hydrogen-bonded singlet carbene intermediate that underwent a protonation-addition mechanism. Applications of this approach in O-H functionalization reactions of alcs., including simple fluorinated, halogenated and aliphatic alcs. and showcase functional-group tolerance of this method in the reaction of biol. active and pharmaceutically relevant alcs. was concluded. In addition to this study using 3,3,3-Trifluoropropan-1-ol, there are many other studies that have used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2COA of Formula: C3H5F3O) was used in this study.

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Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts