Category: 22348-44-3

Application of 22348-44-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22348-44-3, name is trans-4-(Methylamino)cyclohexanol, molecular formula is C7H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 17 trans 1-(4-Hydroxy-cyclohexyl)-3-(4-methoxy-7-[1,4]dioxepan-6-yl-benzothiazol-2-yl)-1-methyl-urea Using 7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-ylamine, phenyl chloroformate and trans-4-methylamino-cyclohexanol, the title compound was prepared as off-white solid. MS: m/e=452(M+H+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 22348-44-3, trans-4-(Methylamino)cyclohexanol.

Reference:
Patent; Flohr, Alexander; Jakob-Roetne, Roland; Norcross, Roger David; Riemer, Claus; US2004/235915; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 22348-44-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.22348-44-3, name is trans-4-(Methylamino)cyclohexanol, molecular formula is C7H15NO, molecular weight is 129.2, as common compound, the synthetic route is as follows.

EXAMPLE 161 2-Acetamino-5-bromo-4-tert.butyl-N-(trans-4′-hydroxy-cyclohexyl)-N-methyl-benzylamine, m.p. 174-176 C, was prepared from 2-acetamino-5-bromo-4-tert.butyl-benzyl bromide and trans-4-methylamino-cyclohexanol analogous to Example 4.

Statistics shows that 22348-44-3 is playing an increasingly important role. we look forward to future research findings about trans-4-(Methylamino)cyclohexanol.

Reference:
Patent; Boehringer Ingelheim GmbH; US4101671; (1978); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 22348-44-3, Adding some certain compound to certain chemical reactions, such as: 22348-44-3, name is trans-4-(Methylamino)cyclohexanol,molecular formula is C7H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22348-44-3.

630 mg of sodium hydride (95%) were suspended in 40 mL of dimethyl acetamide. 1.45 g of 4-methylamino-cyclohexanol (150), dissolved in 40 mL of dimethyl acetamide, were added dropwise and 15 min. later 2.48 g of 6-fluoro-2-(4-methoxy- benzyl)-2H-isoquinolin-1-one (177), dissolved in another 40 mL of dimethyl acetamide, were added. The reaction mixture was stirred at 80 0C until the reaction was complete. The mixture was poured into an ice-water mixture, extracted three times with methyl- tert.-butyl ether and the combined organic layer was dried over sodium sulfate and evaporated. Water was added and the crude product was subjected to lyophilization to remove remainders of dimethyl acetamide.The obtained product is sufficiently pure for further conversion. Rt = 1.24 min (Method B), detected mass: 393.2 (M+H+).

According to the analysis of related databases, 22348-44-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANOFI-AVENTIS DEUTSCHLAND GMBH; WO2007/12422; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 22348-44-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22348-44-3, name is trans-4-(Methylamino)cyclohexanol, molecular formula is C7H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 21 trans-1-(4-Hydroxy-cyclohexyl)-3-[4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-1-methyl-urea Using 4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine, phenyl chloroformate and (trans)-4-methylamino-cyclohexanol, the title compound was prepared as white crystals, mp 160 C., (76% yield). MS: m/e=420(M+H+), mp 160 C.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 22348-44-3, trans-4-(Methylamino)cyclohexanol.

Reference:
Patent; Flohr, Alexander; Jakob-Roetne, Roland; Norcross, Roger David; Riemer, Claus; US2004/235915; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 22348-44-3, name is trans-4-(Methylamino)cyclohexanol. A new synthetic method of this compound is introduced below., COA of Formula: C7H15NO

To a solution of compound 84-2 (140 mg, 1.085 mmol) in DCM (4 mL) was added Boc anhydride (473 mg, 2.170 mmol) and TEA (329 mg, 3.255 mmol), and the reaction solution was stirred at 20 C. for 30 min. After of TLC indicated the reaction was complete, the reaction was quenched with water (30 mL¡Á1), and the aqueous phase was extracted with EtOAc (50 mL¡Á2). Then the organic phases were combined, dried over anhydrous Na2SO4, filtered and evaporated to give compound 84-3 (yellow oil, 180 mg, Yield 72.4%). 1H NMR (400 MHz, CDCl3): delta ppm 6.31 (br. s., 1H), 5.14-5.21 (m, 1H), 4.97 (d, J=6.24 Hz, 2H), 4.48 (d, J=7.09 Hz, 2H), 3.36 (t, J=11.49 Hz, 1H), 2.85 (t, J=11.62 Hz, 1H), 2.18 (br. s., 1H), 1.89 (br. s., 1H), 1.60-1.66 (m, 1H), 1.47 (t, 3H), 1.44 (s, 9H). (1362) LCMS (ESI) m/z: 230 (M+1)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 22348-44-3, trans-4-(Methylamino)cyclohexanol.

Reference:
Patent; Hubei Bio-Pharmaceutical Industrial Technological Institute Inc.; Humanwell Healthcare (Group) Co., Ltd.; Wang, Xuehai; Wu, Chengde; Xu, Yong; Shen, Chunli; Li, Li’e; Hu, Guoping; Yue, Yang; Li, Jian; Guo, Diliang; Shi, Nengyang; Huang, Lu; Chen, Shuhui; Tu, Ronghua; Yang, Zhongwen; Zhang, Xuwen; Xiao, Qiang; Tian, Hua; Yu, Yanping; Chen, Hailiang; Sun, Wenjie; He, Zhenyu; Shen, Jie; Yang, Jing; Tang, Jing; Zhou, Wen; Yu, Jing; Zhang, Yi; Liu, Quan; (251 pag.)US2017/313683; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts