Category: 223251-16-9

Adding a certain compound to certain chemical reactions, such as: 223251-16-9, (4-(2-(Azepan-1-yl)ethoxy)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C15H23NO2, blongs to alcohols-buliding-blocks compound. COA of Formula: C15H23NO2

4-Hydroxybenzyl alcohol (10 g) is added to a solution of sodium hydroxide (7.73 g) in water (150 mL). The mixture is stirred to obtain a clear solution, and then toluene (100 mL), 2-chloroethylazepan hydrochloride (20.74 g), and tetrabutylammonium bromide (0.519 g) are added. The mixture is refluxed for completion of the reaction (1 -1.5 hours), as verified using TLC. The mixture is cooled to 25-35C and the organic layer is separated and washed with 10% NaCI solution (100 mL) at 500C. The organic layer is distilled completely under vacuum, and then dichloromethane (200 mL) is added to the residue. The mixture is stirred for dissolution under a nitrogen atmosphere. Dry HCI gas is passed through the solution for 30-60 minutes at 25-35C and the mixture is stirred for 1 -1.5 hours at the same temperature. About 85-90% of the solvent is distilled from the mixture, then acetone (60 mL) is added, and 85-90% of the solvent is distilled. This addition and distillation step is repeated twice with acetone (60 mL). To the residue, acetone (60 mL) is added and mixture is cooled to 0-50C and further stirred at same temperature for 4-4.5 hours. The solid obtained is filtered under a nitrogen atmosphere, washed with chilled acetone (40 mL) under a nitrogen atmosphere, and dried under vacuum at 50-550C for 4-5 hours to afford the title compound in 61.2% yield.

The synthetic route of 223251-16-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; LEKKALA, Amarnath Reddy; HALDAR, Pranab; MYLAVARAPU, Ravi Kumar; GOLLA, China Malakondaiah; VAGWALA, Raghunath; KARRI, Vijaya Kumar; AKULA, Swapna; WO2011/22596; (2011); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 223251-16-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 223251-16-9 as follows.

This material is prepared from the amino alcohol 1-[2-(4-Hydroxymethyl-phenoxy)-ethyl]azapine by treatment with thionyl chloride in THF at 0C. Resulting solid is used without further purification.1H-NMR (CDCl3) delta 1.7 (m, 2H), 1.9 (m, 4H), 2.2 (m, 2H), 3.1 (m, 2H), 3.4 (7, 2H), 3.6 (t.2H), 6.9 (d, 2H), 7.3 (d, 2H), 12.5 (1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,223251-16-9, its application will become more common.

Reference:
Patent; Wyeth; EP1159267; (2004); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts