Category: 2216-51-5

Comprehensive chocolate aroma characterization in beverages containing jackfruit seed flours and cocoa powder was written by Spada, Fernanda Papa;de Alencar, Severino Matias;Purgatto, Eduardo. And the article was included in Future Foods in 2022.Computed Properties of C10H20O This article mentions the following:

Jackfruit (Artocarpus heterophyllus Lam) occurs abundantly in Brazil, but its seeds are often underutilized in food nutrition. Previously, we showed that roasted jackfruit seeds are an innovative source of chocolate aroma. In this study, we characterized the volatile content of exptl. beverages containing jackfruit seed flours as compared to non-alk. cocoa powder. The three key results of this study were that (i) the fermented jackfruit seed flour beverage (FJSBev) was similar to the non-alk. cocoa powder beverage (CTRLBev); (ii) similar volatile groups (acids, alcs., aldehydes, ester, furans, and pyrazines) were identified in the samples (FJSBev and CTRLBev); (iii) the beverages contained volatile compounds with a low threshold of cocoa attributes (butter, cocoa, coffee, floral, fruit, green, honey, mushroom, nut, and roasted). To conclude, the beverage formulation containing fermented jackfruit seeds had more volatile compounds and odor-active constituents than that with non-alk. cocoa powder. Collectively, our data demonstrate that fermentation is critical to producing a chocolate aroma. Fermented jackfruit seed flours could be used as a partial or total additive to improve chocolate aroma in food formulations. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Computed Properties of C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Three green seaweed extracts and their fractions for ecofriendly management of pestiferous insect Spodoptera litura was written by Sahayaraj, K.;Ravindran, C.;Thusnavis, M. Maria. And the article was included in International Journal of Environmental Science and Technology in 2022.SDS of cas: 2216-51-5 This article mentions the following:

Polyphagous pest Spodoptera litura poses a serious threat to important agriculture crops and their products. A green ecofriendly alternative to existing chem. pesticides, bio-fertilizers are preferred to protect the crop and increase their yield against pests. Hence, three common seaweed crude extracts (Caulerpa scalpelliformis, Caulerpa veravalensis, and Ulva lactuca) and chromatog. fractions of C. scalpelliformis [CS-1 (683-759) and CS-2 (1038-1130)] were screened against S. litura under different concentrations in castor leaves. Dose-dependent mortality was observed for crude extracts and their column chromatog. fractions. Conversely, fractions [CS-1 (683-759) and CS-2 (1038-1130)] recorded highest mortality at 1.0 ppm and lowest at 0.12 ppm. GC-MS anal. of C. scalpelliformis and C. veravalensis exhibited the highest peak of n-Hexadecanoic acid and 1,4-Bis(trimethylsilyl) benzene, resp. The access proportion index suggested C. scalpelliformis was more active than other seaweeds. Henceforth, the results suggest that the above seaweed extracts may be developed as bio-alternative agrochems. for pest control. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5SDS of cas: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nickel-catalyzed Thioester Transfer Reaction with sp²-Hybridized Electrophiles was written by Wu, Xiaopeng;Li, Jinhang;Xia, Siyu;Zhu, Chengjian;Xie, Jin. And the article was included in Journal of Organic Chemistry in 2022.HPLC of Formula: 2216-51-5 This article mentions the following:

Authors report a thioacylation transfer reaction based on nickel-catalyzed C-C bond cleavage of thioesters with sp²-hybridized electrophiles. Aryl bromides, iodides, and alkenyl triflates can participate in thioester transfer reaction of aryl thioesters, affording a wide range of structurally diverse new thioesters in yields of up to 98% under mild reaction conditions. With this protocol, it is possible to construct alkenyl thioesters from the corresponding ketones through the generation of alkenyl triflates. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5HPLC of Formula: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Inhibition of chemically and mechanically activated Piezo1 channels as a mechanism for ameliorating atherosclerosis with salvianolic acid B was written by Pan, Xianmei;Wan, Rentao;Wang, Yuman;Liu, Silin;He, Yu;Deng, Bo;Luo, Shangfei;Chen, Yuan;Wen, Lizhen;Hong, Tianying;Xu, Han;Bian, Yifei;Xia, Mingfeng;Li, Jing. And the article was included in British Journal of Pharmacology in 2022.Formula: C10H20O This article mentions the following:

Salvianolic acid B (SalB) is effective for treating cardiovascular diseases. However, the mol. mechanisms underlying its therapeutic effects remain unclear. Mechanosensitive Piezo1 channels play important roles in vascular biol., although their pharmacol. properties are poorly defined. Here, we aimed to identify novel Piezo1 inhibitors and gain insights into their mechanisms of action. Intracellular Ca2+ ions were measured in HUVECs, murine liver endothelial cells (MLECs), THP-1 and RAW264.7 cell lines and bone marrow-derived macrophages (BMDMs). Isometric tensions in mouse thoracic aorta were recorded. Shear-stress assays with HUVECs were conducted. Patch-clamp recordings with mech. stimulation were performed with HUVECs in whole-cell mode. Foam cell formation was induced by treating BMDMs with oxidised LDL (oxLDL). Atherosclerotic plaque assays were performed with Ldlr-/- and Piezo1 genetically depleted mice on a high-fat diet. Salvianolic acid B inhibited Yoda1-induced Ca2+ influx in HUVECs and MLECs. Similar results were observed in macrophage cell lines and BMDMs. Furthermore, we demonstrated that salvianolic acid B inhibited Yoda1- and mech. activated currents. Salvianolic acid B suppressed Yoda1-induced aortic ring relaxation and inhibited HUVECs alignment in the direction of shear stress. Addnl., Yoda1 enhanced the formation of foam cells, which was reversed by salvianolic acid B. Salvianolic acid B also inhibited formation of atherosclerotic plaques and was insensitive to Piezo1 genetic depletion. Our study provides novel mechanistic insights into the inhibitory role of salvianolic acid B against Piezo1 channels and improves our understanding of salvianolic acid B in preventing atherosclerotic lesions. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Formula: C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Survey of New, Small-Molecule Isatin-Based Oxindole Hybrids as Multi-Targeted Drugs for the Treatment of Alzheimers Disease was written by Marques, Carolina S.;Lopez, Oscar;Leitzbach, Luisa;Fernandez-Bolanos, Jose G.;Stark, Holger;Burke, Anthony J.. And the article was included in Synthesis in 2022.Category: alcohols-buliding-blocks This article mentions the following:

In the last decade, our group has been very active at developing and assaying complex libraries of scaffolds with a focus on their potential to identify bioactive drug candidates for neurodegenerative diseases, particularly Alzheimers disease (AD). Attention has been focused on isatin-based oxindole scaffolds, for which promising results concerning butyrylcholinesterase (BuChE) inhibitory activity have previously been obtained. Considering some published reports and detailed anal. of the pharmacophores of com. available drugs for AD (powerful cholinesterase (ChE) inhibitors), we performed a strategic structural modification of the isatin core and generated a new family of isatin-based oxindole hybrids (27 new compounds) possessing crucial key functional units in their framework. The syntheses were accomplished using multiple approaches, including simple N-alkylation reactions, copper-catalyzed amination reactions, and click chem. The resulting library was evaluated on ChE and MAO enzymes, both of which are involved in the pathophysiol. of neurodegeneration. IC 50values of 1.6 and 2.6 μM (BuChE assays), were achieved for the best inhibitors. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Category: alcohols-buliding-blocks).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of ultrasound pretreatment at different powers on flavor characteristics of enzymatic hydrolysates of cod (Gadus macrocephalus) head was written by Wang, Yuanyuan;Tang, Xuhua;Luan, Junjia;Zhu, Wenhui;Xu, Yongxia;Yi, Shumin;Li, Jianrong;Wang, Jinxiang;Li, Xuepeng. And the article was included in Food Research International in 2022.COA of Formula: C10H20O This article mentions the following:

To make better use of cod head (Gadus macrocephalus), a byproduct of fish processing, the effects of ultrasound pretreatment on the enzymic properties and volatile compounds of cod head enzymic hydrolyzates were investigated. The results demonstrated that ultrasound pretreatment at 150-600 W had a pos. effect cod head enzymic hydrolyzates. The soluble peptides content of the enzymic hydrolyzates reached the highest value of 5.31 ± 0.16 mg/mL at the ultrasound power level of 450 W, and the content of peptide mols. < 3-kDa was up to 93.96%. The type and relative content of volatile compounds, especially aldehydes, alcs., and ketones, also increased with the increase the ultrasound power. The electronic tongue results indicated that ultrasound pretreatment reduced bitterness and astringency. The electronic nose results indicated that the hydrogen- and alkane-containing odor components in the hydrolyzed liquid after ultrasound pretreatment differed significantly from conventional enzymic hydrolyzates. In conclusion, ultrasound pretreatment may be applicable as a suitable technol. to assist enzymic hydrolysis of the cod head, and as such, promote the utilization of fish byproducts. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5COA of Formula: C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discrimination and Characterization of the Volatile Organic Compounds in Schizonepetae Spica from Six Regions of China Using HS-GC-IMS and HS-SPME-GC-MS was written by Li, Chao;Wan, Huiying;Wu, Xinlong;Yin, Jiaxin;Zhu, Limin;Chen, Hanjiang;Song, Xinbo;Han, Lifeng;Yang, Wenzhi;Yu, Heshui;Li, Zheng. And the article was included in Molecules in 2022.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

Volatile organic compounds (VOCs) are the main chem. components of Schizonepetae Spica (SS), which have pos. effects on the quality evaluation of SS. In this study, HS-SPME-GC-MS (headspace solid-phase microextraction-gas chromatog.-mass spectrometry) and HS-GC-IMS (headspace-gas chromatog.-ion mobility spectrometry) were performed to characterize the VOCs of SS from six different regions. A total of 82 VOCs were identified. In addition, this work compared the suitability of two instruments to distinguish SS from different habitats. The regional classification using orthogonal partial least squares discriminant anal. (OPLS-DA) shows that the HS-GC-IMS method can classify samples better than the HS-SPME-GC-MS. This study provided a reference method for identification of the SS from different origins. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Visible Light-Induced Hydrosilylation of Electron-Deficient Alkenes by Iron Catalysis was written by Ding, Ling;Niu, Kaikai;Liu, Yuxiu;Wang, Qingmin. And the article was included in ChemSusChem in 2022.SDS of cas: 2216-51-5 This article mentions the following:

Regioselective photochem. hydrosilylation of activated alkenes R¹CH:CR²(EWG) with Ph₃SiH catalyzed by iron trichloride, afforded linear triphenylsilanes Ph₃SiCHR¹CHR²(EWG) (R¹, R² = H, Me, CF₃, CO₂Me; EWG = carboxylate, CN, CHO, CONHPh). Herein, we reported a method for iron-catalyzed, visible-light-induced hydrosilylation reactions of electron-deficient alkenes to produce value-added silicon compounds Alkenes bearing functional groups with different steric properties were suitable substrates, as were derivatives of structurally complex natural products. Mechanistic studies showed that chlorine radicals generated by iron-catalyzed ligand-to-metal charge transfer in the presence of lithium chloride promoted the formation of silyl radicals. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5SDS of cas: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.SDS of cas: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Catalytic Asymmetric β-Oxygen Elimination was written by Matt, Christof;Orthaber, Andreas;Streuff, Jan. And the article was included in Angewandte Chemie, International Edition in 2022.SDS of cas: 2216-51-5 This article mentions the following:

A catalytic enantioselective β-O-elimination reaction is reported in the form of a zirconium-catalyzed asym. opening of meso-ketene acetals. Furthermore, a regiodivergent β-O-elimination is demonstrated. The reaction proceeds under mild conditions, at low catalyst loadings, and produces chiral monoprotected cis-1,2-diols in good yield and enantiomeric excess. The combination with a Mitsunobu reaction or a one-pot hydroboration/Suzuki reaction sequence then gives access to addnl. diol and aminoalc. building blocks. A stereochem. anal. supported by DFT calculations reveals that a high selectivity in the hydrozirconation step is also important for achieving high enantioselectivity, although it does not constitute the asym. step. This insight is crucial for the future development of related asym. β-elimination reactions. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5SDS of cas: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tf₂O- and Cu(OTf)₂-Assisted Acylamination Reaction of Unactivated Alcohols with Nitriles: A One-Pot P(IV) Activation, Stereoretention in Cycloalkanols and Deprotection Approach was written by Bhat, Mohammad Yaqoob;Ahmed, Sajjad;Ahmed, Qazi Naveed. And the article was included in Journal of Organic Chemistry in 2022.SDS of cas: 2216-51-5 This article mentions the following:

Described herein is a simple, novel, one-pot acylamination reaction of unactivated alcs. This reaction employs the combination of PCl₃ and triflic anhydride (Tf₂O) or copper triflate Cu(OTf)₂, which serves as a source of P(IV)-activated complex for nitriles to react under the Ritter-type mechanism. The synthetic utility of Tf₂O-promoted reactions was demonstrated by its effectiveness to generate different acylaminated products. By employing Cu(OTf)₂, this method represented a rare example of α-selective acylamination reaction. With chiral cycloalkanols, using the Cu(OTf)₂-promoted procedure, acylaminated products were formed with complete retention of configuration. The synthetic utility of the copper-assisted reaction in acetonitrile was readily demonstrated as a mild deprotection strategy. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5SDS of cas: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.SDS of cas: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts