Category: 2216-51-5

Three Different Types of Asymmetric Polymerization of Aryl Isocyanides by Using Simple Rare-Earth Metal Trialkyl Precursors was written by Gao, Feng;Chen, Jupeng;Cao, Qingbin;Li, Qiaozhen;Zheng, Jie;Li, Xiaofang. And the article was included in Macromolecules (Washington, DC, United States) in 2022.Synthetic Route of C10H20O This article mentions the following:

Three different types of asym. polymerization of aryl isocyanides containing helix-sense-selective polymerization of achiral aryl isocyanides with D/L-lactide as the chiral additive, asym. induced polymerization of chiral aryl isocyanides as well as helix-sense-selective copolymerization of chiral and achiral aryl isocyanides with chiral amplification have successfully been implemented by using two kinds of achiral monocation [LnR₂(THF)_n]⁺ or dication species [LnR(THF)_n]²⁺in situ generated from two series of simple rare-earth metal trialkyl precursors (LnR₃(THF)_n, Ln = Sc, Lu, Y; R = -CH₂SiMe₃, -o-CH₂C₆H₄NMe₂; n = 0, 2). As a result, various optically active poly(aryl isocyanide)s having one-handed helical conformations and/or aggregation-induced emission (AIE) nature are prepared A possible coordination mechanism is also proposed. Such a catalytic system affords a new design concept of simple, efficient, and superior rare-earth metal catalysts for asym. polymerization of functional isocyanides. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Synthetic Route of C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Synthetic Route of C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Indium(III)-Catalyzed Synthesis of Primary Carbamates and N-Substituted Ureas was written by Jain, Isha;Malik, Payal. And the article was included in Synlett in 2022.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

An indium triflate-catalyzed synthesis of primary carbamates RXC(O)NH₂ [R = i-Bu, Bn, Ph, etc.; X= O, N] from alcs. and urea as an ecofriendly carbonyl source was developed. Various linear, branched, and cyclic alcs. were converted into the corresponding carbamates in good to excellent yields. This method also provided access to N-substituted ureas by carbamoylation of amines. All the products were obtained by simple filtration or crystallization, without the need for chromatog. purification Mechanistic investigations suggested that the carbamoylation reaction proceeded through activation of urea by O-coordination with indium, followed by nucleophilic attack by the alc. or amine on the carbonyl center of urea. The inexpensive and easily available starting materials and catalyst, the short reaction times, and the ease of product isolation highlighted the inherent practicality of the developed method. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novel deep eutectic solvent-based liquid phase microextraction for the extraction of estrogenic compounds from environmental samples was written by Fattahi, Nazir;Shamsipur, Mojtaba;Nematifar, Ziba;Babajani, Nasrin;Moradi, Masoud;Soltani, Shahin;Akbari, Shahram. And the article was included in RSC Advances in 2022.Application of 2216-51-5 This article mentions the following:

Steroid hormones, such as estrone (E1), 17尾-estradiol (E2), 17尾-ethinylestradiol (EE2) and estriol (E3) are a group of lipophilic active substances, synthesized biol. from cholesterol or chem. A pH-switchable hydrophobic deep eutectic solvent-based liquid phase microextraction (DES-LPME) technique was established and combined with gas chromatog.-mass spectroscopy for the determination of estrogenic compounds in environmental water and wastewater samples. A DES was synthesized using l-menthol as HBA and (1S)-(+)-camphor-10-sulfonic acid (CSA) as HBD, and used as a green extraction solvent. By adjusting the pH of the solution, the unique behavior of the DES in the phase transition and extraction of the desired analytes was investigated. The homogenization process of the mixture is done only by manual shaking in less than 30 s and the phase separation is done only by changing the pH and without centrifugation. Some effective parameters on the extraction and derivatization, such as molar ratio of DES components, DES volume, KOH concentration, HCl volume, salt addition, extraction and derivatization time and derivatization prior or after extraction were studied and optimized. Under the optimum conditions, relative standard deviation (RSD) values for intra-day and inter-day of the method based on 7 replicate measurements of 20 ng L-1 of estrogenic compounds and 10 ng L-1 for internal standard in different samples were in the range of 2.2-4.6% and 3.9-5.7%, resp. The calibration graphs were linear in the range of 0.5-100 ng L-1 and the limits of detection (LODs) were in the range of 0.2-1.0 ng L-1. The relative recoveries of environmental water and wastewater samples which have been spiked with different levels of target compounds were 91.0-108.8%. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Application of 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application of 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iridium-Catalyzed Branch-Selective and Enantioselective Hydroalkenylation of 伪-Olefins through C-H Cleavage of Enamides was written by Sun, Xin;Lin, En-Ze;Li, Bi-Jie. And the article was included in Journal of the American Chemical Society in 2022.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

Catalytic branch-selective hydrofunctionalization of feedstock 伪-olefins to form enantioenriched chiral compounds is a particularly attractive yet challenging transformation in asym. catalysis. Herein, an iridium-catalyzed asym. hydroalkenylation of 伪-olefins through directed C-H cleavage of enamides was reported. This atom-economical addition process is highly branch-selective and enantioselective, delivering trisubstituted alkenes with an allylic stereocenter. DFT calculations reveal the origin of regio- and enantioselectivity. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hypervalent Iodine(III) Reagents with Transferable Primary Amines: Structure and Reactivity on the Electrophilic 伪-Amination of Stabilized Enolates was written by Poeira, Diogo L.;Negrao, Ana Claudia R.;Faustino, Helio;Coelho, Jaime A. S.;Gomes, Clara S. B.;Gois, Pedro M. P.;Marques, M. Manuel B.. And the article was included in Organic Letters in 2022.SDS of cas: 2216-51-5 This article mentions the following:

A new family of hypervalent iodine reagents containing transferable primary amine groups is described. The benziodoxolone-based reagents were synthesized on a gram-scale through operationally simple reactions in up to quant. yields. These bench-stable solids were characterized by X-ray anal. and successfully employed in the 伪-amination of indanone-based 尾-ketoesters in up to 83% yield. Mechanistic studies indicate a substitution mechanism involving an electrophilic amine. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5SDS of cas: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Three Different Types of Asymmetric Polymerization of Aryl Isocyanides by Using Simple Rare-Earth Metal Trialkyl Precursors was written by Gao, Feng;Chen, Jupeng;Cao, Qingbin;Li, Qiaozhen;Zheng, Jie;Li, Xiaofang. And the article was included in Macromolecules (Washington, DC, United States) in 2022.Synthetic Route of C10H20O This article mentions the following:

Three different types of asym. polymerization of aryl isocyanides containing helix-sense-selective polymerization of achiral aryl isocyanides with D/L-lactide as the chiral additive, asym. induced polymerization of chiral aryl isocyanides as well as helix-sense-selective copolymerization of chiral and achiral aryl isocyanides with chiral amplification have successfully been implemented by using two kinds of achiral monocation [LnR₂(THF)_n]⁺ or dication species [LnR(THF)_n]²⁺in situ generated from two series of simple rare-earth metal trialkyl precursors (LnR₃(THF)_n, Ln = Sc, Lu, Y; R = -CH₂SiMe₃, -o-CH₂C₆H₄NMe₂; n = 0, 2). As a result, various optically active poly(aryl isocyanide)s having one-handed helical conformations and/or aggregation-induced emission (AIE) nature are prepared A possible coordination mechanism is also proposed. Such a catalytic system affords a new design concept of simple, efficient, and superior rare-earth metal catalysts for asym. polymerization of functional isocyanides. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Synthetic Route of C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Synthetic Route of C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Indium(III)-Catalyzed Synthesis of Primary Carbamates and N-Substituted Ureas was written by Jain, Isha;Malik, Payal. And the article was included in Synlett in 2022.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

An indium triflate-catalyzed synthesis of primary carbamates RXC(O)NH₂ [R = i-Bu, Bn, Ph, etc.; X= O, N] from alcs. and urea as an ecofriendly carbonyl source was developed. Various linear, branched, and cyclic alcs. were converted into the corresponding carbamates in good to excellent yields. This method also provided access to N-substituted ureas by carbamoylation of amines. All the products were obtained by simple filtration or crystallization, without the need for chromatog. purification Mechanistic investigations suggested that the carbamoylation reaction proceeded through activation of urea by O-coordination with indium, followed by nucleophilic attack by the alc. or amine on the carbonyl center of urea. The inexpensive and easily available starting materials and catalyst, the short reaction times, and the ease of product isolation highlighted the inherent practicality of the developed method. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novel deep eutectic solvent-based liquid phase microextraction for the extraction of estrogenic compounds from environmental samples was written by Fattahi, Nazir;Shamsipur, Mojtaba;Nematifar, Ziba;Babajani, Nasrin;Moradi, Masoud;Soltani, Shahin;Akbari, Shahram. And the article was included in RSC Advances in 2022.Application of 2216-51-5 This article mentions the following:

Steroid hormones, such as estrone (E1), 17β-estradiol (E2), 17β-ethinylestradiol (EE2) and estriol (E3) are a group of lipophilic active substances, synthesized biol. from cholesterol or chem. A pH-switchable hydrophobic deep eutectic solvent-based liquid phase microextraction (DES-LPME) technique was established and combined with gas chromatog.-mass spectroscopy for the determination of estrogenic compounds in environmental water and wastewater samples. A DES was synthesized using l-menthol as HBA and (1S)-(+)-camphor-10-sulfonic acid (CSA) as HBD, and used as a green extraction solvent. By adjusting the pH of the solution, the unique behavior of the DES in the phase transition and extraction of the desired analytes was investigated. The homogenization process of the mixture is done only by manual shaking in less than 30 s and the phase separation is done only by changing the pH and without centrifugation. Some effective parameters on the extraction and derivatization, such as molar ratio of DES components, DES volume, KOH concentration, HCl volume, salt addition, extraction and derivatization time and derivatization prior or after extraction were studied and optimized. Under the optimum conditions, relative standard deviation (RSD) values for intra-day and inter-day of the method based on 7 replicate measurements of 20 ng L-1 of estrogenic compounds and 10 ng L-1 for internal standard in different samples were in the range of 2.2-4.6% and 3.9-5.7%, resp. The calibration graphs were linear in the range of 0.5-100 ng L-1 and the limits of detection (LODs) were in the range of 0.2-1.0 ng L-1. The relative recoveries of environmental water and wastewater samples which have been spiked with different levels of target compounds were 91.0-108.8%. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Application of 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application of 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iridium-Catalyzed Branch-Selective and Enantioselective Hydroalkenylation of α-Olefins through C-H Cleavage of Enamides was written by Sun, Xin;Lin, En-Ze;Li, Bi-Jie. And the article was included in Journal of the American Chemical Society in 2022.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

Catalytic branch-selective hydrofunctionalization of feedstock α-olefins to form enantioenriched chiral compounds is a particularly attractive yet challenging transformation in asym. catalysis. Herein, an iridium-catalyzed asym. hydroalkenylation of α-olefins through directed C-H cleavage of enamides was reported. This atom-economical addition process is highly branch-selective and enantioselective, delivering trisubstituted alkenes with an allylic stereocenter. DFT calculations reveal the origin of regio- and enantioselectivity. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hypervalent Iodine(III) Reagents with Transferable Primary Amines: Structure and Reactivity on the Electrophilic α-Amination of Stabilized Enolates was written by Poeira, Diogo L.;Negrao, Ana Claudia R.;Faustino, Helio;Coelho, Jaime A. S.;Gomes, Clara S. B.;Gois, Pedro M. P.;Marques, M. Manuel B.. And the article was included in Organic Letters in 2022.SDS of cas: 2216-51-5 This article mentions the following:

A new family of hypervalent iodine reagents containing transferable primary amine groups is described. The benziodoxolone-based reagents were synthesized on a gram-scale through operationally simple reactions in up to quant. yields. These bench-stable solids were characterized by X-ray anal. and successfully employed in the α-amination of indanone-based β-ketoesters in up to 83% yield. Mechanistic studies indicate a substitution mechanism involving an electrophilic amine. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5SDS of cas: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts