Category: 2215-78-3

Application of 2215-78-3 ,Some common heterocyclic compound, 2215-78-3, molecular formula is C13H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Manufacturing Example 34-1-1 1-Chloromethyl-4-phenoxy-benzene; To a solution of (4-phenoxy-phenyl)-methanol (408 mg, 2.04 mmol) in carbon tetrachloride (8.2 mL) was added triphenylphosphine (642 mg, 2.45 mmol) under nitrogen atmosphere at room temperature, and the reaction solution was stirred under reflux for 7 hours and 40 minutes. The reaction mixture was cooled to room temperature and concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=10:1) to obtain the title compound (409 mg, 92%).1H-NMR Spectrum (DMSO-d6) delta (ppm): 4.76 (2H, s), 6.98-7.05 (4H, m), 7.15-7.19 (1H, m), 7.39-7.46 (4H, m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2215-78-3, its application will become more common.

Reference:
Patent; Tanaka, Keigo; Yamamoto, Eiichi; Watanabe, Naoaki; US2009/82403; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 2215-78-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2215-78-3, name is (4-Phenoxyphenyl)methanol, molecular formula is C13H12O2, molecular weight is 200.2332, as common compound, the synthetic route is as follows.

General procedure: p-Nitrobenzyl alcohol (0.25 g, 1.63 mmol) was dissolved in anhydrous CH2Cl2 under N2. Triethylamine (0.227 mL, 1.63 mmol) was added and the resulting solution was cooled to 0 C. S2Cl2 (65.3 muL, 0.82 mmol) was added dropwise over 20 min. The solution was stirred at 0 C for 2 h before being allowed to equilibrate to room temperature for 3 h. The reaction was quenched with dH20, washed with 2 × 20 mL aliquots of brine. The aqueous phase was extracted with CH2Cl2 (2 × 10 mL), and the combined organic was dried over MgSO4, filtered, and concentrated under reduced pressure. Column chromatography with a 2.5:1 ratio of hexanes:ethyl acetate afforded:

The chemical industry reduces the impact on the environment during synthesis 2215-78-3, I believe this compound will play a more active role in future production and life.

Reference:
Article; Stoutenburg, Eric G.; Palermo, Anne E.; Priefer, Ronny; Thermochimica Acta; vol. 551; (2013); p. 99 – 103;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2215-78-3, name is (4-Phenoxyphenyl)methanol, molecular formula is C13H12O2, molecular weight is 200.2332, as common compound, the synthetic route is as follows.Application In Synthesis of (4-Phenoxyphenyl)methanol

Thionyl chloride (13.34 g) was added to 4.06 g of 4-phenoxybenzyl alcohol, and the mixture was stirred at 80 C. for 3.5 hours.. After the completion of the concentration, the reaction mixture was extracted with ethyl acetate and with water.. The organic layer was concentrated to give 4.31 g of 4-phenoxybenzyl chloride. Properties of the compound: 1H-NMR(CDCl3, delta): 4..58(2H, s), 6.96-7.03(4H, m), 7.11-7.14(1H, m), 7.32-7.37(4H, m)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2215-78-3, (4-Phenoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6352985; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 2215-78-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2215-78-3, name is (4-Phenoxyphenyl)methanol. A new synthetic method of this compound is introduced below.

To a solution of (4-phenoxy-phenyl)-methanol (408 mg, 2.04 mmol) in carbon tetrachloride (8.2 mL) was added triphenylphosphine (642 mg, 2.45 mmol) under nitrogen atmosphere at room temperature, and the reaction solution was stirred under reflux for 7 hours and 40 minutes. The reaction mixture was cooled to room temperature and concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=10:1) to obtain the title compound (409 mg, 92%). 1H-NMR Spectrum (DMSO-d6) delta (ppm): 4.76 (2H, s), 6.98-7.05 (4H, m), 7.15-7.19 (1H, m), 7.39-7.46 (4H, m).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2215-78-3, (4-Phenoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Eisai R&D Management Co., Ltd.; US2007/105904; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 2215-78-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2215-78-3, name is (4-Phenoxyphenyl)methanol, molecular formula is C13H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Phenoxybenzyl alcohol (20.0 g) was dissolved in toluene (100 mL), and thionyl chloride (13.1 g) was added to the solution over 30 minutes at room temperature. After 2 hours, the reaction solution was concentrated under reduced pressure. The residue was distilled to give 16.7 g (yield: 76%) of the target product. A boiling point thereof was 137 C/3 mmHg.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2215-78-3, (4-Phenoxyphenyl)methanol.

Reference:
Patent; Agro Kanesho Co Ltd; Aizawa, Ryo; Okada, Itaru; (13 pag.)KR2016/85330; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2215-78-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2215-78-3, name is (4-Phenoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

PRODUCTION EXAMPLE 4 Production of Compound (35) by Production Process E To a solution of 0.46 g of 4-(3,3-dichloro-2-propenyloxy)-2,6-dichlorophenol, 0.32 g of p-phenoxybenzyl alcohol and 0.46 g of triphenylphosphine dissolved in 10 ml of tetrahydrofuran was added dropwise a solution of 0.35 g of diisopropylazodicarboxylate dissolved in 5 ml of tetrahydrofuran, while stirring at room temperature. After stirring at room temperature for 12 hours, the reaction mixture was concentrated, and then mixed with 20 ml of diethyl ether. The precipitate was filtered, and the filtrate was concentrated. The residue was subjected to silica gel chromatography, which afforded 0.51 g of 3,5-dichloro-4-(4-phenoxybenzyl)-1-(3,3-dichloro-2-propenyloxy)benzene (68% yield), nD25.5 1.6084.

According to the analysis of related databases, 2215-78-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sumitomo Chemical Company, Limited; US5872137; (1999); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2215-78-3 ,Some common heterocyclic compound, 2215-78-3, molecular formula is C13H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

First, 2-amino-6-methylnicotinic acid (3.04 g) was suspended in m-xylene (20 mL), potassium carbonate (4.15 g) was added thereto, followed by stirring for 30 minutes at 40 C. to obtain Solution 1. On the other hand, (4-phenoxyphenyl)methanol (4.00 g) was dissolved in m-xylene (7 mL), thionyl chloride (1.46 mL) was added dropwise at ice-cold temperature, followed by stirring for 30 minutes while returning to the room temperature. Then, hydrogen chloride, sulfur dioxide and thionyl chloride in the system were evaporated, Solution 1 was added, tetrabutylammonium bromide (194 mg) was added, followed by stirring under heating for 4 hours at 110 C. The reaction solution was cooled to room temperature and about 95% of m-xylene was evaporated under reduced pressure. Ice water was added to the residue, followed by stirring for 30 minutes at room temperature. The precipitated crystal was collected by filtration and dried and 6.39 g (yield of 95.7%, volume efficiency of 25%) of the target substance (compound 2 described in Table 1) was obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2215-78-3, (4-Phenoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AGRO-KANESHO CO., LTD.; AIZAWA, Ryo; ARAKI, Koichi; (6 pag.)US2018/362464; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 2215-78-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2215-78-3, name is (4-Phenoxyphenyl)methanol, molecular formula is C13H12O2, molecular weight is 200.2332, as common compound, the synthetic route is as follows.

Under an argon atmosphere and dissolved in the above process resulting in 1 4-phenoxyphenylmethanol (122) (300 mg), DPPA (495 mg) in anhydrous DMF (2.7 mL). DBU the (274 mg) was added under ice cooling,the mixture was stirred for 2 hours, the mixture was further stirred for 24 hours at room temperature. Water was added to the reaction mixture, the reaction mixture was extracted with ethyl acetate (30 mL). The organic layer 2N aqueous hydrochloric acid (30 mL), washed with saturated brine (30 mL), dried over anhydrous sodiumsulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel flash columnchromatography (developing solvent nhexane:ethyl acetate = 50: 1) to give the title compound (103 mg, 30% yield) as acolorless oil.

Statistics shows that 2215-78-3 is playing an increasingly important role. we look forward to future research findings about (4-Phenoxyphenyl)methanol.

Reference:
Patent; Nagoya City University; Miyata, Naoki; Suzuki, Takayoshi; Ota, Yosuke; Ueda, Ryuzo; Ida, Shinsuke; Rie, Masaki; (47 pag.)JP5725475; (2015); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 2215-78-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2215-78-3, name is (4-Phenoxyphenyl)methanol, molecular formula is C13H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-benzylamino nicotinic acid (0.228 g) in 1,2-dichloroethane, 4-phenoxybenzyl alcohol (0.200 g), 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0. 230 g) and 4-dimethylaminopyridine (0.146 g) was added, the mixture was heated and stirred for 2 h at 80 C. After cooling to room temperature, added water and extracted with methylene chloride and extracted with further methylene chloride and the aqueous layer. The combined organic layers were dried over anhydrous sodium sulfate. And concentrated under reduced pressure, and the obtained residue is purified by silica gel column chromatography, compounds of the present invention described in Table 1 (No. 1), to give 0.246 g, an oil.

According to the analysis of related databases, 2215-78-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AGRO-KANESHOCOMPANY LIMITED; AIZAWA, RYO; HONMA, ATSUKO; OKADA, ITARU; HATAMOTO, MASAHIRO; FUKUCHI, TOSHIKI; (12 pag.)JP2016/11277; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts