Category: 217479-60-2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 217479-60-2, name is 2,4,6-Trichlorobenzyl alcohol, the common compound, a new synthetic route is introduced below. Recommanded Product: 217479-60-2

a) Preparation of 1 ,3,5-trichloro-2-chloromethyl-benzene:To a stirred solution of 2,4,6-trichlorobenzylalcohol (10.0g; 47.3 mmoles) in chloroform (100ml) kept under nitrogen atmosphere, thionyl chloride (6.07ml_, 85.1 mmole) was added slowly at O0C over a period of 15 minutes followed by catalytic amount of DMF The reaction mix was allowed to stir at ambient temp for 3 hours. The reaction mixture was quenched with 5OmL of water; the aqueous layer was extracted with DCM (3 X 100ml). The combined organic layer was washed with 5% sodium bicarbonate solution (2 x 50ml) followed by brine (50ml) and dried over anhydrous sodium sulphate. The solvent was evaporated under reduced pressure. 10.9g (100.0% of theory) of 1 ,3,5-trichloro-2-chloromethyl-benzene was obtained in form of a white solid.1 HNMR (CDCI3, 400MHz): delta= 7.37 (2H, s); 4.82 (2H, s) Mass: M = 229.8

The synthetic route of 217479-60-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; RAJAN, Ramya; WALTER, Harald; STIERLI, Daniel; WO2010/63700; (2010); A2;,
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Synthetic Route of 217479-60-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 217479-60-2, name is 2,4,6-Trichlorobenzyl alcohol, molecular formula is C7H5Cl3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example P9 Preparation of 1,3,5-trichloro-2-chloromethyl-benzene To a stirred solution of 2,4,6-trichlorobenzylalcohol (10.0 g; 47.3 mmol) in chloroform (100 ml) kept under nitrogen atmosphere, thionyl chloride (6.07 ml; 85.1 mmol) was added slowly at 0 C. over a period of 15 minutes followed by catalytic amount of DMF. The reaction mix was allowed to stir at ambient temp for 3 hours. The reaction mixture was quenched with 50 ml of water; the aqueous layer was extracted with DCM (3*100 ml). The combined organic layer was washed with 5% sodium bicarbonate solution (2*50 ml) followed by brine (50 ml) and dried over anhydrous sodium sulphate. The solvent was evaporated under reduced pressure. 10.9 g (100% of theory) of 1,3,5-trichloro-2-chloromethyl-benzene was obtained in form of a white solid. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 7.37 (s, 2H); 4.82 (s, 2H) MS [M+H]+231/233.

According to the analysis of related databases, 217479-60-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SYNGENTA CROP PROTECTION LLC; Stierli, Daniel; Walter, Harald; US2013/72535; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 217479-60-2, name is 2,4,6-Trichlorobenzyl alcohol, molecular formula is C7H5Cl3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2,4,6-Trichlorobenzyl alcohol

Tert-butyl 4-{6-[(2,4,6-trichlorophenyl)methoxy]-2H-spiro[l- benzofuran-3,4′-piperidine]-l’-yl}butanoate. To a solution of (2,4,6- trichlorophenyl)methanol (164.5 mg; 0.78 mmol) and tert-butyl 4-{6-hydroxy- 2H-spiro[l-benzofuran-3,4′-piperidine]- l’-yl}butanoate (250 mg; 0.62 mmol) in dichloromethane (20 mL) was added triphenylphosphine (204 mg; 0.78 mmol), followed, after 30 minutes by DIAD (0.15 mL; 0.78 mmol). Subsequently, the resulting mixture was stirred at RT overnight, and concentrated in vacuo. Subsequently, the reaction mixture was partitioned between 5% aqueous NaHC03 solution and EtOAc. The layers were separated and the organic layer was dried (Na2S04), filtered, and concentrated. The residue was purified by column chromatography (S1O2, Et20: hexanes 1:2) to afford the product (174 mg, 52%). Rt 1.59 min (System B), [M+H]+ 542.0.

With the rapid development of chemical substances, we look forward to future research findings about 217479-60-2.

Reference:
Patent; ABBOTT HEALTHCARE PRODUCTS B.V.; STOIT, Axel; IWEMA BAKKER, Wouter, I.; COOLEN, Hein K.A.C.; VAN DONGEN, Maria J.P.; LEFLEMME, Nicolas J.-L.D.; WO2012/4378; (2012); A1;,
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Reference of 217479-60-2, Adding some certain compound to certain chemical reactions, such as: 217479-60-2, name is 2,4,6-Trichlorobenzyl alcohol,molecular formula is C7H5Cl3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 217479-60-2.

To a stirred solution of 2,4,6-trichlorobenzylalcohol (10.0 g; 47.3 mmoles) in chloroform (100 ml) kept under nitrogen atmosphere, thionyl chloride (6.07 mL, 85.1 mmole) was added slowly at 0 C. over a period of 15 minutes followed by catalytic amount of DMF. The reaction mix was allowed to stir at ambient temp for 3 hours. The reaction mixture was quenched with 50 mL of water; the aqueous layer was extracted with DCM (3*100 ml). The combined organic layer was washed with 5% sodium bicarbonate solution (2*50 ml) followed by brine (50 ml) and dried over anhydrous sodium sulphate. The solvent was evaporated under reduced pressure. 10.9 g (100.0% of theory) of 1,3,5-trichloro-2-chloromethyl-benzene was obtained in form of a white solid. 1HNMR (CDCl3, 400 MHz): delta=7.37 (2H, s); 4.82 (2H, s) Mass: M=229.8

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 217479-60-2, 2,4,6-Trichlorobenzyl alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SYNGENTA CROP PROTECTION LLC; US2011/230537; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 217479-60-2, name is 2,4,6-Trichlorobenzyl alcohol. A new synthetic method of this compound is introduced below., name: 2,4,6-Trichlorobenzyl alcohol

PREPARATION EXAMPLE 4: N-rri -(2.4.6-trichlorophenvncvclopropyllmethvn-3- (trifluoromethyl)pyridine-2-carboxamide (Compound A29)Step 1 : 1 ,3,5-trichloro-2-(chloromethyl)benzeneTo a stirred solution of (2,4,6-trichlorophenyl)methanol (2g, 9.4574 mmol) in chloroform (20 mL) kept under N2 atmosphere, thionyl chloride (1 .25 ml_, 17.023 mmol), was added slowly at 0C over a period of 10 min followed by a catalytic amount of DMF (35 mg, 0.4733 mmol). The reaction mixture was allowed to stirred at RT for 2h.The reaction mixture was quenched with 10 mL of water; the aqueous layer is extracted with dichloromethane (3 times). The combined organic layer were washed with 5% Na2C03 solution (2*10 mL), followed by NaCI (10mL) and dried over Na2S04. The solvent was evaporated under reduced pressure to give an yellow oil (1.78 gr). The oil was diluted in EtOAc and washed twice with NaCI (3 mL), then dried over NaS04, filtrated and evaporated to give 1.58 g of desired product.1H-NMR (CDCI3): 7.4 (s, 2H); 4.8 (s, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 217479-60-2, 2,4,6-Trichlorobenzyl alcohol.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; LOISELEUR, Olivier; PITTERNA, Thomas; O’SULLIVAN, Anthony, Cornelius; LUKSCH, Torsten; KICKOVA, Anna; WO2013/64520; (2013); A1;,
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