Category: 2173-69-5

Adding a certain compound to certain chemical reactions, such as: 2173-69-5, 2-Methyl-2-phenyl-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C10H14O, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C10H14O

2-methyl-2-phenyl-propanol (Intermediate 3) (0.5 kg) and pyridine (268 ml) were charged to a reactor and chilled to 0C. Acetic anhydride (680 gms) was slowly added through a dropper at 10-20C. The mixture was stirred for 2 hours at 10-20C. Ethyl acetate (1.5 ltr) was added and chilled water (2 ltrs) was slowly added through a dropper at 10-20C. The mixture was stirred FOR 4 hr. The ethyl acetate layer was separated and 10% chilled dilute HC1 was added. The ethyl acetate layer was then washed with sodium bicarbonate until a pH of 7 was obtained. The ethyl acetate layer was dried with sodium sulphate and concentrated under vacuum. The resulting oil was distilled under vacuum (15 mm OF HG). at 80-100C.

The synthetic route of 2173-69-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CIPLA LIMITED; WAIN, Christopher, Paul; WO2005/19175; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2173-69-5, Adding some certain compound to certain chemical reactions, such as: 2173-69-5, name is 2-Methyl-2-phenyl-1-propanol,molecular formula is C10H14O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2173-69-5.

A solution of 2-METHYL-2-PHENYLPROPAN-1-OL (160mg) (J. Org Chem 1982,47, 2476-2479) in DMF (8ml) under nitrogen was treated with sodium hydride (60% dispersion in mineral oil, 47mg) and the mixture stirred at 20 for 15min. (5R)-3-(6-Bromohexyl)-5-(2, 2- DIMETHYL-4H-1, 3-BENZODIOXIN-6-YL)-1, 3-OXAZOLIDIN-2-ONE (400mg) was then added and the mixture was stirred at 20 for 5h. Phosphate buffer solution (pH 6.5, 15MOI) and water (15ml) were added and the mixture was extracted with EtOAc. The extract was washed with water and dried (NA2SO4). The solvent was evaporated in vacuo and the residue purified by flash chromatography on silica gel. Elution with ETOAC-PETROLEUM ether (1: 4) then (1: 2) gave an oil which was further purified by preparative thin layer chromatography on a silica plate (20 x 20cm). Elution with isopropyl acetate-toluene (2: 3) gave the title compound (100mg). LCMS RT = 3.92 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2173-69-5, 2-Methyl-2-phenyl-1-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2004/37768; (2004); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 2173-69-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2173-69-5 as follows.

To a solution of 2-methyl-2-phenyl-propan-1-ol (13.3 g, 87.0 mmol) in DMSO (150 mL) was added triethylamine (24.7 mL, 178.0 mmo) at rt, followed by pyridine sulfuric oxide (28.6 g, 180.0 mmol). The mixture was stirred for 2.5 h at rt. Water was added and the resulting mixture was extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and concentrated to obtain the crude product 2-methyl-2-phenyl- propionaldehyde (12.0 mg, 91.6 %), which was used to the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2173-69-5, its application will become more common.

Reference:
Patent; NOVO NORDISK A/S; WO2008/84044; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts