Category: 2160-93-2

On July 31, 2017, Perinu, Cristina; Bernhardsen, Ida M.; Svendsen, Hallvard F.; Jens, Klaus-J. published an article.Product Details of 2160-93-2 The title of the article was CO2 Capture by Aqueous 3-(Methylamino)propylamine in Blend with Tertiary Amines: An NMR Analysis. And the article contained the following:

Aqueous 3-(Methylamino)propylamine (MAPA) in blend with 2-(Diethylamino)ethanol (DEEA) and other tertiary amines, which mainly differ from DEEA in the number of hydroxyl functions (-OH) and/or in the length and structure of their alkyl chain, are investigated. After absorption of carbon dioxide (CO2) at 40°C, quant. 13C NMR experiments are performed to calculate the concentration of the species in each blend at equilibrium, together with qual. NMR experiments for signal assignment. Speciation and absorption capacity data are discussed in terms of chem. structure and basicity of the tertiary amines. In general, it is observed that, at increasing pKa of the tertiary amines (decreasing number of -OH on the structure), there is a decrease of MAPA and primary and secondary MAPA carbamates, and an increase of MAPA dicarbamate, (bi)carbonate and of the absorption capacity. Within the mols. with the same number of -OH but differently branched, some exceptions are found. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Product Details of 2160-93-2

The Article related to methylaminopropylamine tertiary amine solvent blend nmr carbon dioxide capture, Air Pollution and Industrial Hygiene: Other and other aspects.Product Details of 2160-93-2

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On September 18, 1997, Leung, Hon-Wing; Ballantyne, Bryan published an article.Related Products of 2160-93-2 The title of the article was Evaluation of the genotoxic potential of alkylalkanolamines. And the article contained the following:

Three alkylalkanolamines, N,N-dimethylethanolamine, N-methyldiethanolamine, and tert-butyldiethanolamine, were evaluated for potential genotoxic activity using the Salmonella/microsome reverse gene mutation test, the CHO/HGPRT forward gene mutation test, a sister chromatid exchange test in cultured CHO cells, and an in vivo peripheral blood micronucleus test in Swiss-Webster mice. None of the three alkylalkanolamines produced any significant or dose-related increases in the frequencies of mutations, sister chromatid exchanges or micronuclei. These results indicate that N,N-dimethylethanolamine, N-methyldiethanolamine, and tert-butyldiethanolamine are not genotoxic in the tests conducted. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Related Products of 2160-93-2

The Article related to genotoxic potential alkylalkanolamine, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Related Products of 2160-93-2

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On June 5, 2003, Aranapakam, Venkatesan; Davis, Jamie M.; Grosu, George T.; Baker, Jannie; Ellingboe, John; Zask, Arie; Levin, Jeremy I.; Sandanayaka, Vincent P.; Du, Mila; Skotnicki, Jerauld S.; DiJoseph, John F.; Sung, Amy; Sharr, Michele A.; Killar, Loran M.; Walter, Thomas; Jin, Guixian; Cowling, Rebecca; Tillett, Jeff; Zhao, Weiguang; McDevitt, Joseph; Xu, Zhang Bao published an article.Formula: C8H19NO2 The title of the article was Synthesis and Structure-Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis. And the article contained the following:

A series of novel and orally active N-substituted 4-benzenesulfonylpiperidine-4-carboxylic acid hydroxyamide derivatives have been synthesized and their structure-activity relationships determined Among the several compounds synthesized, I turned out to be a potent, selective, and an orally active MMP inhibitor in the clin. relevant advanced rabbit osteoarthritis model. Pharmacokinetics and metabolism data are reported. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Formula: C8H19NO2

The Article related to arylsulfonylpiperidinehydroxamic acid preparation matrix metalloproteinase inhibitor structure activity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C8H19NO2

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On November 20, 2002, Bazylak, Grzegorz; Nagels, Luc J. published an article.Name: 2,2′-(tert-Butylazanediyl)diethanol The title of the article was Potentiometric detection of N,N’-diethylaminoethanol and lysosomotropic amino alcohols in cation-exchange high-performance liquid-chromatography systems. And the article contained the following:

Potentiometric detection of N,N’-diethylaminoethanol (DEAE) and a series of related physiol. relevant lysosomotropic amino alcs. was carried out by cation-exchange HPLC. Poly(vinyl chloride) (PVC)-based liquid membrane electrode coatings were used which contained the lipophilic cation exchanger tetrakis(p-chlorophenyl)borate (TCPB) either alone or in combination with one of the macrocyclic ionophores hexakis-(2,3,6-tri-O-octyl)-α-cyclodextrin (CDX), dibenzo-18-crown-6 (CRW) or calix[6]arene hexaethylacetate ester (CLX). With all the PVC membrane electrodes used, improved sensitivity over UV detection at 210 nm was obtained for the aliphatic amino alcs. analyzed. Especially, addition of CLX to the PVC-based membrane led to highly enhanced detection limits for the lower-mol.-weight lysosomotropic amino compounds, i.e., aminoethanol and methylamine. The performance of the proposed potentiometric detection method was demonstrated in cation-exchange HPLC modes employing two different aqueous mobile phase systems with pH 2.30 comprising H3PO4 or HOAc with MeCN as organic modifier. Detection limits of 1.1 × 10-8 and 2.4 × 10-8M (injected concentrations) were achieved for N-methylaminoethanol and hexylamine, resp., by using a CLX-based electrode. Sensitive and reliable determination of DEAE, a local anesthetic agent, after liquid-liquid or solid-phase extraction from fortified bovine serum samples was obtained with the HPLC method coupled with the proposed potentiometric detection system. A linear free-energy relationship based on a general solvation equation was used to predict detection limits of amino alcs. from their mol. structure in the potentiometric detectors employing CLX and CRW. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Name: 2,2′-(tert-Butylazanediyl)diethanol

The Article related to amino alc determination hplc potentiometry, diethylaminoethanol determination blood liquid chromatog potentiometry, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: 2,2′-(tert-Butylazanediyl)diethanol

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On November 30, 1995, Hermansky, Steven J.; Neptun, Douglas A.; Weaver, Elizabeth V.; Ballantyne, Bryan published an article.Related Products of 2160-93-2 The title of the article was Clinical pathology changes related to cutaneous irritation in the Fischer 344 rat and New Zealand White rabbit. And the article contained the following:

An evaluation of 27 repeated dose cutaneous application studies (9 applications of 6 h over an 11-day period) indicated that several hematol. and clin. chem. parameters may be altered by chem. induced skin irritation. Irresp. of species, values that were generally decreased included Hb concentration, hematocrit, erythrocyte count, and serum concentrations of calcium, potassium, inorganic phosphorus, and creatinine. Values that were increased included the neutrophil and total leukocyte counts. Some species differences were seen; for example, while the platelet count and serum globulin concentration were increased in rabbits only, the serum glucose, sodium, and chloride concentrations were increased in rats only. The mean corpuscular volume (MCV), mean corpuscular Hb (MCH), and serum albumin and total protein concentrations were variably affected. Changes were generally well associated with the degree of cutaneous irritation, but did not appear to be related to the chem. class of the test substances, decreased food consumption, loss of body weight, or systemic toxicity of the chem. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Related Products of 2160-93-2

The Article related to chem toxicity cutaneous irritation pathol, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Related Products of 2160-93-2

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On December 31, 1996, Ballantyne, Bryan; Leung, Hon-Wing published an article.Related Products of 2160-93-2 The title of the article was Acute toxicity and primary irritancy of alkylalkanolamines. And the article contained the following:

The acute handling hazards of several alkylalkanolamines were determined by investigating their potential acute toxicity and primary irritancy. Materials studied were N-methylethanolamine (MEA), N, N-dimethylethanolamine (DMEA), N, N-dimethylisopropanolamine (DMIPA), N-methyldiethanolamine (MDEA), and tert-butyldiethanolamine (BDEA). All these alkylalkanolamines were of comparable acute peroral toxicity in the rat (LD50 range 1.48-2.83 mL/kg). By 24 h occluded epicutaneous contact in the rabbit, MEA, DMEA and DMIPA were of moderate acute percutaneous toxicity (LD50 range 1.13-2.0 mL/kg), MDEA was of slight acute percutaneous toxicity (LD50 male 9.85 mL/kg, female 10.90 mL/kg), and BDEA of intermediate toxicity (LD50 6.4 mL/kg). Due to differences in vapor pressure the acute vapor exposure toxicity of the alkylalkanolamines to rats varied; MEA, MDEA and BDEA were of a low order of acute toxicity, and DMIPA was moderately toxic with an LT50 of 3.2 h for a saturated vapor atm. exposure. A 4 h-LC50 (rat combined sex) of 1461 ppm was determined for DMEA. All alkylalkanolamines studied, except MDEA, were moderately to markedly irritating and caused variable degrees of skin corrosivity; MDEA caused only transient minor skin irritation. In accord with the skin irritancy results, the eye irritancy from 0.005 mL MEA, DMEA, DMIPA and BDEA was severe, and that from MDEA was slight. Exposure to these compounds has implications for occupational health procedures. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Related Products of 2160-93-2

The Article related to acute toxicity irritancy alkylalkanolamine, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Related Products of 2160-93-2

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Gannon, J. E.; Adams, M. C.; Bennett, E. O. published an article in 1978, the title of the article was Microbial degradation of diethanolamine and related compounds.Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol And the article contains the following content:

Thirteen diethanolamine compounds were tested for their biodegradability employing (1) a bacterium selectively isolated from an industrial cutting fluid, and (2) an acclimatized sewage population obtained from a domestic waste treatment plant. Pure culture growth and BOD studies with the isolate showed that only diethanolamine [111-42-2], methyldiethanolamine [105-59-9], triethanolamine [102-71-6] and lauryl sulfate diethanolamine [72430-24-1] were degradable. BOD techniques using the acclimatized sewage microorganisms as seed yielded similar results with only diethanolamine, methyldiethanolamine, triethanolamine, and lauryl sulfate diethanolamine being oxidized to any meaningful extent. Cyclohexyldiethanolamine [4500-29-2], phenyldiethanolamine [120-07-0], and m-tolyldiethanolamine [91-99-6] had O demands of <1% of their theor. calculated values, while ethyldiethanolamine [139-87-7] and benzyldiethanolamine [101-32-6] accounted for 3.6 and 2.3% of their theor. values, resp. In both systems employed substitution of the tertiary H of the amine group with iso-Pr, 3-aminopropyl, Bu, or tert-Bu resulted in biol. recalcitrant compounds The experimental process involved the reaction of 2,2'-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol

The Article related to microorganism diethanolamine derivative degradation, triethanolamine degradation microorganism, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol

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On June 30, 1987, Robert, Dominique; Gawad, Hoda Abdel; Riess, Jean G. published an article.SDS of cas: 2160-93-2 The title of the article was Fluorophosphoranes as Lewis acids. The conditions of access to hexacoordinated neutral adducts via the intramolecular addition of an electron donor. And the article contained the following:

The preparation of bicyclic neutral hexacoordinated fluorophosphorus adducts (I) from RPF4 (R = F, Me, Ph) and (Me3SiOCH2CH2)2X (X = O, S, NH, NMe, NCMe3, NPh) was examined Adduct I was formed predominantly only in the case where R = F and X = S. In all the other cases there was a strong tendency to form ionic species. The 8-membered dialkoxyfluorophosphorane model precursor II (X = CH2) does not form easily, and the driving force towards the formation of the very stable RPF5- anions and of tetracoordinated phosphorylated species leads to its easy decomposition The monocyclic adducts of type III and IV are not easier to prepare: compound V only could be obtained where X = NH2 and R = F, while the spirophosphorane VI was isolated when R = Ph. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).SDS of cas: 2160-93-2

The Article related to hexacoordinated fluorophosphorus adduct, fluorophosphorane lewis acid reaction, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.SDS of cas: 2160-93-2

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On March 31, 1994, Houalla, Douraid; Moureau, Loeticia; Skouta, Said; Wolf, Robert published an article.Electric Literature of 2160-93-2 The title of the article was New bicyclophosphoranic macrocycles. II. Mixed macrocycles derived from 3-oxa-, 3-amino- and 3-thia-1,5-pentanediols. And the article contained the following:

New bis- (1-5; shown as I; X = S, O, NPh, NMe; Y = NCMe3, S, O, NPh), tris- (6,7) and tetrakis(bicyclophosphoranes) (8-10) containing macrocycles were obtained by a Todd reaction between the corresponding bis(hydridobicyclophosphoranes) (II) and four 1,5-pentanediols HO(CH2)2Y(CH2)2OH (Y = O, S, NCMe3, NPh). I were formed in moderate (29-45%) yields. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Electric Literature of 2160-93-2

The Article related to macrocycle bicyclophosphorane, pentanediol atherton todd reaction hydridobicyclophosphorane, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Electric Literature of 2160-93-2

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Osman, F. H.; El-Hamouly, W. S.; Abdel-Gawad, M. M.; Abbasi, M. M. published an article in 1982, the title of the article was The behavior of 2,2′-(tert-butylimino)diethanol toward five-membered heterocycles containing phosphorus(III).Safety of 2,2′-(tert-Butylazanediyl)diethanol And the article contains the following content:

The reaction of 2,2′-(tert-butylimino)diethanol Me3CN(CH2CH2OH)2 (I) with dioxaphospholanes II (X = Cl, NMe2) gave III. Thermal reaction of III with I gives a complete rearrangement yielding a mixture of spirophosphorane IV, V, and traces of another product. III reacts with Ph azide to give a mixture of penta- and tetracoordinated phosphorus structures VI and VII, resp. Biacetyl condenses with III to give VIII. Reaction of dioxaphospholane IX (X = Cl) with I yields a mixture of the biphosphite V and another product believed to be either triethylammonium tris(o-phenylenedioxy) phosphate or spirobenzodioxaphospholane X. Similarly, dioxaphospholane IX (X = NMe2) reacts with I forming a mixture of XI and XII. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Safety of 2,2′-(tert-Butylazanediyl)diethanol

The Article related to iminodiethanol reaction dioxaphospholane, ethylene bisphosphite reaction, spirophosphorane, tetraoxaphosphaspirononene, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Safety of 2,2′-(tert-Butylazanediyl)diethanol

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