Category: 20880-92-6

Lu, Xiao-Yu published the artcileDual Nickel/Ruthenium Strategy for Photoinduced Decarboxylative Cross-Coupling of α,β-Unsaturated Carboxylic Acids with Cycloketone Oxime Esters, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Journal of Organic Chemistry (2021), 86(13), 8829-8842, database is CAplus and MEDLINE.

Herein, a dual nickel/ruthenium strategy is developed for photoinduced decarboxylative cross-coupling between α,β-unsaturated carboxylic acids and cycloketone oxime esters. The reaction mechanism is distinct from previous photoinduced decarboxylation of α,β-unsaturated carboxylic acids. This reaction might proceed through a nickelacyclopropane intermediate. The C(sp²)-C(sp³) bond constructed by the aforementioned reaction provides an efficient approach to obtaining various cyanoalkyl alkenes, which are synthetically valuable organic skeletons in organic and medicinal chem., under mild reaction conditions. The protocol tolerates many critical functional groups and provides a route for the modification of complex organic mols.

Journal of Organic Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Haigen published the artcileCopper-Catalyzed Radical Bis(trifluoromethylation) of Alkynes and 1,3-Enynes, Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Synlett (2020), 31(1), 41-44, database is CAplus.

The copper-catalyzed radical bis(trifluoromethylation) of alkynes ArCCH [Ar = 4-tert-butylphenyl, phenanthren-9-yl, 2-methyl-1,3-benzothiazol-6-yl, [4-([[(1R,2S,5R)-5-methyl-2-(propan-2- yl)cyclohexyl]oxy]carbonyl)phenyl], etc.] and 1,3-enynes R¹CCC(=CH₂)R² (R¹ = 4-bromophenyl, 9-oxo-9H-fluoren-2-yl, 3-[(benzenesulfonyl)oxy]propyl, etc.; R² = H, Me) is described. With Cu(CH₃CN)₄BF₄as the catalyst, the reaction of arylalkynes with Togni reagent II and (bpy)Zn(CF₃)₂ at room temperature affords the corresponding 1,2-bis(trifluoromethylated) alkenes ArC(CF₃)=CHCF₃ in good yields with excellent E-stereoselectivity. Under similar conditions, the reaction of 1,3-enynes provides the corresponding 1,4-bis(trifluoromethylated) allenes R¹C(CF₃)=C=C(CH₂CF₃)R² exclusively in satisfactory yields. The protocol exhibits broad substrate scope and excellent functional group compatibility.

Synlett published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H10O4S, Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xiao, Cong published the artcileLight-promoted nickel catalysis: etherification of aryl electrophiles with alcohols catalyzed by Ni (II)/aryl complex, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Youji Huaxue (2020), 40(9), 3004-3006, database is CAplus.

In this paper, a highly efficient photo promoted nickel catalyzed C-O bond coupling reaction was realized. The reaction uses air stable Ni (II) – aryl halide as catalyst and DBU as base without external photosensitizer.

Youji Huaxue published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H15NO, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ganda, Sylvia published the artcileCorona-Loading Strategies for Crystalline Particles Made by Living Crystallization-Driven Self-Assembly, COA of Formula: C12H20O6, the publication is Macromolecules (Washington, DC, United States) (2021), 54(14), 6662-6669, database is CAplus.

Self-assembled block copolymer (BCP) nanoparticles offer exciting opportunities for drug delivery applications. A key feature of using BCP nanoparticles for drug delivery is their ability to accommodate therapeutic cargoes within their particle core. This has become widely established for BCP nanoparticles with an amorphous core. The same, however, cannot be achieved with BCP nanoparticles with a crystalline core. This is because the encapsulation of therapeutic cargoes in a crystalline particle core disrupts crystallinity and ultimately leads to particle disassembly. Herein, we present several strategies to incorporate therapeutics and other functional cargoes onto the surface of crystalline particles, as this helps to ensure that the crystallinity of the particle core is maintained and the particle morphol. is hence unaffected. As a platform to showcase our strategies, in this study, we used biodegradable and bioactive 2D glycoplatelets prepared by living crystallization-driven self-assembly (CDSA). Specifically, we show that we can incorporate either an anticancer drug, doxorubicin (DOX), or a fluorescent dye, Cyanine5 (Cy5), onto the surface of glycoplatelets by seeded growth of prefunctionalized polymers or via postmodification using polymers with reactive handles. We believe that the strategies presented herein are versatile and should thus be applicable to other CDSA systems. Overall, our findings present new opportunities for crystalline particles to be used in drug delivery application.

Macromolecules (Washington, DC, United States) published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, COA of Formula: C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rodygin, Konstantin S. published the artcileA Green and Sustainable Route to Carbohydrate Vinyl Ethers for Accessing Bioinspired Materials with a Unique Microspherical Morphology, COA of Formula: C12H20O6, the publication is ChemSusChem (2018), 11(1), 292-298, database is CAplus and MEDLINE.

Synthesizing chems. and materials from renewable sources is one of the main aims of modern science. Carbohydrates represent excellent renewable natural raw materials that are ecofriendly, inexpensive, and biol. compatible. A green procedure has been developed for the vinylation of carbohydrates by using readily available calcium carbide. Various carbohydrates were utilized as starting materials, resulting in mono-, di-, and tetravinyl ethers in high to excellent yields (81-92 %). The synthesized biobased vinyl ethers were utilized as monomers in free radical and cationic polymerizations A unique combination of a smooth surface and intrinsic microcompartments was achieved in the synthesized materials. Two types of biobased materials were prepared involving microspheres and intrinsic hollow compartments in polymers. SEM with built-in ion beam cutting was applied to reveal the spatial hierarchical structures in 3D space.

ChemSusChem published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, COA of Formula: C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ren, Xinyi published the artcileAsymmetric Alkoxy- and Hydroxy-Carbonylations of Functionalized Alkenes Assisted by β-Carbonyl Groups, Application In Synthesis of 20880-92-6, the publication is Angewandte Chemie, International Edition (2021), 60(32), 17693-17700, database is CAplus and MEDLINE.

As a fundamental type of carbonylation reaction, the alkoxy- and hydroxy-carbonylation of unsaturated hydrocarbons constitutes one of the most important industrial applications of homogeneous catalysis. However, owing to the difficulties in controlling multi-selectivities for asym. hydrocarbonylation of alkenes, this reaction is typically limited to vinylarenes and analogs. In this work, a highly efficient asym. alkoxy- and hydroxy-carbonylation of β-carbonyl functionalized alkenes was developed, providing practical and easy access to various densely functionalized chiral mols. with high optical purity from broadly available alkenes, CO, and nucleophiles (>90 examples, 84-99% ee). This protocol features mild reaction conditions and a broad substrate scope, and the products can be readily transformed into a diverse array of chiral heterocycles. Control experiments revealed the key role of the β-carbonyl group in determining the enantioselectivity and promoting the activity, which facilitates chiral induction by coordination to the transition metal as rationalized by DFT calculations The strategy of utilizing an innate functional group as the directing group on the alkene substrate might find further applications in catalytic asym. hydrocarbonylation reactions.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Application In Synthesis of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Xi published the artcileNickel-catalyzed allylic defluorinative alkylation of trifluoromethyl alkenes with reductive decarboxylation of redox-active esters, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Chemical Science (2019), 10(3), 809-814, database is CAplus and MEDLINE.

An efficient method was developed for the synthesis of functionalized gem-difluoroalkenes I [R = c-hexyl, 4-BrC₆H₄(CH₂)₂, 4-CNC₆H₄O(CH₂)₂C(Me)₂, etc.; Ar = 3,4-(OMe)₂C₆H₃, 4-PhC₆H₄, 2-naphthyl, etc.] via nickel-catalyzed defluorinative reductive cross-coupling of trifluoromethyl alkenes with redox-active esters. The present reaction involved C(sp³)-F bond cleavage and C(sp³)-C(sp³) bond formation under very mild reaction conditions, while tolerating many sensitive functional groups and requiring minimal substrate protection. Therefore, this method provided an efficient and convenient approach for late-stage modification of biol. interesting mols.

Chemical Science published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Jiang published the artcileLate-stage construction of stapled peptides through Fujiwara-Moritani reaction between tryptophan and olefins, Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(88), 11661-11664, database is CAplus and MEDLINE.

Herein, the first example of a palladium-catalyzed Fujiwara-Moritani reaction for olefination of tryptophan (Trp) residues, free from directing groups, was presented. The developed reaction proceeds efficiently for peptide modification, ligation and peptide stapling.

Chemical Communications (Cambridge, United Kingdom) published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xing, Wei-Long published the artcileEfficient Decarboxylative/Defluorinative Alkylation for the Synthesis of gem-Difluoroalkenes through an S_N2′ Type Route, Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Chinese Journal of Chemistry (2022), 40(3), 323-328, database is CAplus.

An efficient decarboxylative/defluorinative alkylation for synthesizing gem-difluoroalkenes F₂C:CRCH₂CR¹R²R³ [R = 4-PhC₆H₄, naphthalen-2-yl, 1-methyl-1H-indol-5-yl, etc.; R¹ = H, Me, Et; R² = H, Me, Et, Ph, etc.; R¹R² = (CH₂)₃; R³ = Ph, CN, COOEt, etc.] is described, providing a general method for installation of the challenging alkyl fragments containing γ-electron-withdrawing groups into γ-trifluoromethyl alkenes RC(CF₃):CH₂. Mechanistic studies suggest that this process involves an S_N2′-type synthetic route in the absence of transition-metal catalysts or photocatalysis. Moreover, this protocol can easily be scaled up, and successfully applied to the modification of biol. active mols., thus complementing methodologies that give access to structurally versatile gem-difluoroalkenes.

Chinese Journal of Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C14H12O3, Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nischang, Ivo published the artcileHydrodynamic Analysis Resolves the Pharmaceutically-Relevant Absolute Molar Mass and Solution Properties of Synthetic Poly(ethylene glycol)s Created by Varying Initiation Sites, Product Details of C12H20O6, the publication is Analytical Chemistry (Washington, DC, United States) (2017), 89(2), 1185-1193, database is CAplus and MEDLINE.

The solution behavior originating from mol. characteristics of synthetic macromols. plays a pivotal role in many areas, in particular the life sciences. This situation necessitates the use of complementary hydrodynamic anal. methods as the only means for a complete structural understanding of any macromol. in solution To this end, we present a combined hydrodynamic approach for studying inhouse prepared, low dispersity poly(ethylene glycols)s (PEGs), also known as poly (ethylene oxide)s (PEOs) depending on the classification used, synthesized from varying initiation sites by living anionic ring opening polymerization The series of linear PEGs in the molar mass range of only a few thousand to 50 000 g mol-1 were studied in detail via viscometry, and sedimentation-diffusion anal. by anal. ultracentrifugation. The obtained estimations for intrinsic viscosity, diffusion coefficients, and sedimentation coefficients of the macromols. in the solution-based anal. clearly showed self-consistency of the followed hydrodynamic approach. This self-consistency is underpinned by appropriate and phys.-sound values of hydrodynamic invariants, indicating adequate values of derived absolute molar masses. The classical scaling relations of Kuhn-Mark-Houwink-Sakurada of all molar-mass dependent hydrodynamic estimates show linear trends, allowing for interrelation of all parametric macromol. characteristics. Differences among these are ascribed to the observation of α-end and chain-length dependent solvation of the macromols., identified from viscometric studies. This important information al-lows for anal. tracing of variations of scaling relationships and a phys.-sound estimation of hydrodynamic characteristics. The demonstrated self-sufficient methodol. paves an important way for a complete structural understanding and potential replacement of pharmaceutically-relevant PEGs by alternative macromols. offering a suite of similar or tractably distinct physicochem. properties.

Analytical Chemistry (Washington, DC, United States) published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts