Category: 20880-92-6

Zhang, Tao; Luan, Yu-Xin; Lam, Nelson Y. S.; Li, Jiang-Fei; Li, Yue; Ye, Mengchun; Yu, Jin-Quan published their research in Nature Chemistry on December 31 ,2021. The article was titled 《A directive Ni catalyst overrides conventional site selectivity in pyridine C-H alkenylationã€?Application In Synthesis of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol The article contains the following contents:

Herein, application of bifunctional N-heterocyclic carbene-ligated Ni-Al catalyst in C3-H alkenylation of pyridines was described. This method overrode the intrinsic C2 and/or C4 selectivity, and provided a series of C3-alkenylated pyridines such as I in 43-99% yields and up to 98:2 C3 selectivity. This method not only allowed a variety of pyridine and heteroarene substrates to be used as the limiting reagent, but was also effective for the late-stage C3 alkenylation of diverse complex pyridine motifs in bioactive mols. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Application In Synthesis of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)â€? And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Application In Synthesis of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tu, Jia-Lin; Liu, Jia-Li; Tang, Wan; Su, Ma; Liu, Feng published an article on February 7 ,2020. The article was titled 《Radical Aza-Cyclization of α-Imino-oxy Acids for Synthesis of Alkene-Containing N-Heterocycles via Dual Cobaloxime and Photoredox Catalysisã€? and you may find the article in Organic Letters.Product Details of 20880-92-6 The information in the text is summarized as follows:

Nitrogen-containing heterocycles are prevalent in both naturally and synthetically bioactive mols. We report herein an unprecedented protocol for radical aza-cyclization of α-imino-oxy acids with pendant alkenes via synergistic photoredox and cobaloxime catalysis. With or without alkenes as the intermol. cross-coupling partners, the transformation provides a variety of corresponding alkene-containing dihydropyrrole products in satisfactory yields. In the presence of external alkenes, the tandem reaction generates E-selective coupling products with excellent chemo- and stereoselectivity. In the experiment, the researchers used many compounds, for example, ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Product Details of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)â€? And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Product Details of 20880-92-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

SDS of cas: 20880-92-6On September 3, 2021 ,《Nickel-Catalyzed Arylation of C(sp3)-O Bonds in Allylic Alkyl Ethers with Organoboron Compoundsã€?was published in Organic Letters. The article was written by Li, Xiaowei; Li, Yuxiu; Zhang, Zhong; Shi, Xiaolin; Liu, Ruihua; Wang, Zemin; Li, Xiangqian; Shi, Dayong. The article contains the following contents:

A nickel-catalyzed cross-coupling of allylic alkyl ethers with organoboron compounds through the cleavage of the inert C(sp3)-O(alkyl) bonds is described. Several types of allylic alkyl ethers can be coupled with various boronic acids or their derivatives to give the corresponding products in good to excellent yields with wide functional group tolerance and excellent regioselectivity. The gram-scale reaction and late-stage modification of biol. active compounds further prove the practicality of this synthetic method. In the experimental materials used by the author, we found ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6SDS of cas: 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)â€?SDS of cas: 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Jia-Xin; Ge, Wei; Fu, Ming-Chen; Fu, Yao published an article on February 25 ,2022. The article was titled 《Photoredox-Catalyzed Allylic Defluorinative Alkoxycarbonylation of Trifluoromethyl Alkenes through Intermolecular Alkoxycarbonyl Radical Additionã€? and you may find the article in Organic Letters.Formula: C12H20O6 The information in the text is summarized as follows:

Herein, a photoredox-catalyzed allylic defluorinative alkoxycarbonylation of trifluoromethyl alkenes ArC(CF3):CH2 (Ar = 4-BrC6H4, naphthalen-2-yl, 6-methoxypyridin-3-yl, etc.) enabled by intermol. alkoxycarbonyl radical addition is disclosed. A wide variety of alc. oxalate derivatives ROC(O)CO2H (R = Me, t-Bu, cyclopentyl, L-menthyl, N-Boc-piperidin-4-yl, etc.) was amenable, affording various β-gem-difluoroalkene esters ArC(:CF2)CH2COOR with excellent functional group tolerance. Notably, the potential synthetic value of this method is highlighted by successful late-stage modification for bioactive mols. In the experimental materials used by the author, we found ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Formula: C12H20O6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)â€? And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Formula: C12H20O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanolOn June 10, 2022, Chen, Yi-Xuan; He, Jun-Tao; Wu, Mei-Chun; Liu, Zhi-Lin; Tang, Kai; Xia, Peng-Ju; Chen, Kai; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua published an article in Organic Letters. The article was 《Photochemical Organocatalytic Aerobic Cleavage of C=C Bonds Enabled by Charge-Transfer Complex Formationã€? The article mentions the following:

A novel visible-light-driven organocatalytic protocol to access aerobic oxidative cleavage of olefins, e.g., 4-benzylidene-2,6-di-tert-butylcyclohexa-2,5-dien-1-one promoted by sodium benzene sulfinate, is described. An array of alkenes smoothly delivered the corresponding aldehydes RC(O)R1 (R = naphth-2-yl, 2-chlorophenyl, 3,4-dimethoxyphenyl, etc.; R1 = H) and ketones, e.g., 2, 6-di-tert-butylcyclohexa-2, 5-diene-1,4-dione under transition-metal-free conditions. Notably, α-halo-substituted styrenes, e.g., (1-bromovinyl)benzene proceeded with photoinduced oxidation to finally afford α-halo-acetophenones, e.g., 2-bromo-1-phenylethan-1-one with halogen migration. Crucial to this oxidation was the formation of charge-transfer complexes between sodium benzene sulfinate with mol. O2 to ultimately deliver the carbonyl products. In the experiment, the researchers used many compounds, for example, ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)â€?Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C12H20O6On May 4, 2020 ,《Self-Assembled Nucleotide/Saccharide-Tethering Polycation-Based Nanoparticle for Targeted Tumor Therapyã€?appeared in ACS Materials Letters. The author of the article were Yu, Dan; Zhang, Na; Liu, Siyuan; Hu, Wenting; Nie, Jing-Jun; Zhang, Kai; Yu, Bingran; Wang, Zhen-Gang; Xu, Fu-Jian. The article conveys some information:

Development of novel concepts to construct drug vehicles for efficient encapsulation of hydrophobic drugs and targeted therapy is highly desirable to biomedical science. It remains a challenge to create effective noncovalent linkage between the components within the drug vectors. In this work, we report a supramol. approach to construct multifunctional nanoparticles, which combined tumor-targeting capability via saccharide, cell penetration via pos.-charged surface, and chemotherapeutic function via drug delivery for cancer therapy. A endogenous self-associating nucleotide (guanosine monophosphate) noncovalently bonded with a hydrophobic nucleoside analog drug (clofarabine) to form nanofibrils, which were transformed to spherical nanoparticles by assembling with a fructose/ethanolamine-functionalized starlike poly(glycidyl methacrylate)-based cationic polymer. Noncovalent cavities within the nanoparticles were created, through the nucleotide self-association, and acted as linkage between the hydrophilic cationic polymer and the drug. The saccharide-tethering polycation and nucleotide components were labeled with fluorescent dyes, resp., to image the endocytosis and biodistribution. In vitro and in vivo results show that the functional nanoparticles exhibited good capabilities of the targeted accumulation of the nanoparticles and delivery of drugs in cancer cells and tumor sites, leading to a robust anticancer effect. In addition to this study using ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, there are many other studies that have used ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6COA of Formula: C12H20O6) was used in this study.

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)â€?COA of Formula: C12H20O6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Computed Properties of C12H20O6On March 14, 2022, Schoch, Silvia; Iacopini, Dalila; Dalla Pozza, Maria; Di Pietro, Sebastiano; Degano, Ilaria; Gasser, Gilles; Di Bussolo, Valeria; Marchetti, Fabio published an article in Organometallics. The article was 《Tethering Carbohydrates to the Vinyliminium Ligand of Antiproliferative Organometallic Diiron Complexes》. The article mentions the following:

Four propargyl O-glycosides derivatized with mannose, glucose, and fructose moieties were synthesized and then incorporated within a diiron structure as part of a vinyliminium ligand. Hence, six glycoconjugated diiron complexes, [2-5]CF3SO3 (see Scheme 1) and the nonglycosylated analogs [6a-b]CF3SO3, were obtained in high yields and unambiguously characterized by elemental anal., mass spectrometry, and IR and multinuclear NMR spectroscopies. All compounds exhibited a significant stability in DMSO-d6/D2O solution, with 63-89% of the complexes unaltered after 72 h at 37° and also in the cell culture medium. The cytotoxicity of [2-6]CF3SO3, as well as that of previously reported 7 and 8, was assessed on CT26 (mouse colon carcinoma), U87 (human glioblastoma), MCF-7 (human breast adenocarcinoma), and RPE-1 (human normal retina pigmented epithelium) cell lines. In general, the IC50 values correlate with the hydrophobicity of the compounds (measured as octanol-H2O partition coefficients) and do not show an appreciable level of selectivity against cancer cells with respect to the nontumor ones. In addition to this study using ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, there are many other studies that have used ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Computed Properties of C12H20O6) was used in this study.

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Computed Properties of C12H20O6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Direct Synthesis of Deuterium-Labeled O -, S -, N -Vinyl Derivatives from Calcium Carbide》 was written by Ledovskaya, Maria S.; Voronin, Vladimir V.; Rodygin, Konstantin S.; Posvyatenko, Alexandra V.; Egorova, Ksenia S.; Ananikov, Valentine P.. Synthetic Route of C12H20O6 And the article was included in Synthesis on August 31 ,2019. The article conveys some information:

A novel methodol. for the preparation of trideuterovinyl derivatives such as I [R = n-decyl, menthyl, Ph, etc.; X = O, S] and II [R1 = indol-1-yl, NPh2, carbazol-9-yl, etc.] of high purity directly from alcs., thiols, and NH-compounds was developed. Com. available calcium carbide and D2O acted as a D2-acetylene source and DMSO-d6 was used to complete the formation of the D2C=C(D)-X fragment (X = O, S, N). Polymerization of a selected trideuterovinylated compound showed a very promising potential of these substances in the synthesis of labeled polymeric materials. Biol. activity of the synthesized trideuterovinyl derivatives was evaluated and the results indicated a significant increase of cytotoxicity upon deuteration. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Synthetic Route of C12H20O6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Synthetic Route of C12H20O6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanolOn June 8, 2020, Yildirim, Ayhan; Goeker, Mustafa published an article in ChemistrySelect. The article was 《D-Fructose-Derived Acetonide as a Green Neutral Organocatalyst for Proficient One-Pot and Three-Component Preparation of 1,3-Benzoxazine Monomers》. The article mentions the following:

A series of 1,3-benzoxazine monomers were successfully synthesized by simple one-pot and three-component condensation of phenol, paraformaldehyde and varying types of primary aliphatic and aromatic amines in a molar ratio of 1 : 2 : 1 and in the presence of non-acidic 2,3;4,5-di-O-isopropylidene-β-D-fructopyranose as an effective green carbohydrate based organocatalyst obtained from renewable feedstock. This multicomponent method provided a convenient fast approach for the construction of valuable 1,3-benzoxazine monomers (8 examples) with moderate to excellent yields. The chem. structures of the synthesized benzoxazines were confirmed by FTIR, 1H NMR, 13C NMR spectra and elemental anal. The experimental part of the paper was very detailed, including the reaction process of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 20880-92-6On September 30, 2020 ,《An Expedient Method for Kinetically Controlled Acetonide Formation from D-Fructose Induced by Ionic Liquid Catalyst Accompanied with SrCl2·6H2O》 was published in Catalysis Letters. The article was written by Yildirim, Ayhan. The article contains the following contents:

The present work was undertaken to ascertain whether IL-metal salt catalyzed isopropylidenation of D-fructose yield desired acetonides. For the first time, an imidazole based ionic liquid compound accompanied with strontium chloride has been identified as a suitable dual catalyst system for the chemoselective O-isopropylidenation of D-fructose with acetone. In the present protocol, mainly the kinetically controlled less stable cyclic ketal 1,2;4,5-di-O-isopropylidene-β-D-fructopyranose is formed as an initial product with satisfactory yield and without isomerization to the thermodynamically more stable cyclic ketal 2,3;4,5-di-O-isopropylidene-β-D-fructopyranose. Therefore, this protocol is more advantageous compared to other mineral acid catalyzed protocols that require more sensitive reaction conditions. After reading the article, we found that the author used ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Related Products of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Related Products of 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts