Category: 20712-12-3

Synthetic Route of 20712-12-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 20712-12-3, name is (2-Amino-5-bromophenyl)methanol. A new synthetic method of this compound is introduced below.

A mixture of (2-amino-5-bromophenyl)methanol (10 g, 49.5 mmol) and MnO2 (25.8 g, 296.6 mmol) in CH2Cl2 (400 mL) was stirred at RT overnight. LCMS showed the reaction was completed. The solid was filtered off, and the filtrate was concentrated to give the title compound as a light yellow solid (8 g, 81percent), which was directly used in next step without further purification. MS (ES+) C7H6BrNO requires: 199, found: 200, 202 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,20712-12-3, (2-Amino-5-bromophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; Bifulco, JR., Neil; DiPietro, Lucian V.; Miduturu, Chandrasekhar V.; US2015/197519; (2015); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20712-12-3, name is (2-Amino-5-bromophenyl)methanol, molecular formula is C7H8BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 20712-12-3

A mixture of (2-amino-5-bromophenyl)methanol (10 g, 49.5 mmol) and MnO2 (25.8 g, 296.6 mmol) in CH2Cl2 (400 mL) was stirred at RT overnight. LCMS showed the reaction was completed. The solid was filtered off, and the filtrate was concentrated to give the title compound as a light yellow solid (8 g, 81percent), which was directly used in next step without further purification. MS (ES+) C7H6BrNO requires: 199, found: 200, 202 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 20712-12-3.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; Bifulco, Jr., Neil; DiPietro, Lucian V.; Miduturu, Chandrasekhar V.; (41 pag.)US9695165; (2017); B2;,
Alcohol – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20712-12-3, name is (2-Amino-5-bromophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H8BrNO

General procedure: A mixture of 2-aminobenzyl alcohol 1 (0.2 mmol), allylic alcohol 2(0.4 mmol), [IrCp*Cl2]2 (0.0020 mmol, 1.0 molpercent), and KOH (0.2 mmol) were dissolved in anhyd toluene (1 mL) in a 25-mL Schlenk tube. The system was flushed with N2 and allowed to react at the specified temperatureand for the specified time. The mixture was allowed to cool to r.t. and filtered through a short silica gel column (washed with EtOAc). Removal of the solvent left an oil that was separated by column chromatography (silica gel, EtOAc?hexane) to give the quinoline.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 20712-12-3, (2-Amino-5-bromophenyl)methanol.

Reference:
Article; Chen, Shu-Jie; Lu, Guo-Ping; Cai, Chun; Synthesis; vol. 47; 7; (2015); p. 976 – 984;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20712-12-3, name is (2-Amino-5-bromophenyl)methanol, molecular formula is C7H8BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks

Synthesis of 6-bromo-2-(3,5-dimethylphenyl)quinoline(2-Amino-5-bromophenyl)methanol (22 g, 109 mmol), 3,5-dimethylacetophenone (24.2 g, 163 mmol), RuCl2(PPh3)3 (1.05 g, 1.09 mmol), KOH (11.0 g, 196 mmol) were refluxed in 270 mL of toluene for 18 h.Water was collected from the reaction using a Dean-stark trap.The reaction mixture was allowed to cool to room temperature and filtered through a silica gel plug and eluted with 5percent ethyl acetate in hexanes.The product was further purified by Kugelrohr distillation and crystallization from methanol.

With the rapid development of chemical substances, we look forward to future research findings about 20712-12-3.

Reference:
Patent; Universal Display Corporation; US2012/217868; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 20712-12-3, Adding some certain compound to certain chemical reactions, such as: 20712-12-3, name is (2-Amino-5-bromophenyl)methanol,molecular formula is C7H8BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20712-12-3.

(l) To a mixture of lithium aluminum hydride (2.6 g, 69 mmol) in diethyl ether (54 ml) was added dropwise 5-bromoanthranillic acid methyl ester (6.3 g, 27 mmol) in diethyl ether (54 ml) at Ot). The mixture was stirred at O1C for 3 hours. Then water (2.6 ml), 15 wtpercent aqueous solution of sodium hydroxide (2.6 ml) and water (7.8 ml) was addedsequentially at O1C. The mixture was filtrated through a pad of Celite, and concentrated in vacuo. The residue was dissolved into tetrahydrofuran (160 ml), and triethylamine (15 g, 150 mmol) was added. The mixture was cooled to Ot, and trichloromethyl chloroformate (2.9 g, 15 mmol) was added. The mixture was stirred at room temperature for 4 hours. The mixture was partitioned between water and ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, and concentrated in vacuo to afford crude product. This crude product was washed with diethyl ether to afford6-bromo-l,4-dihydro-2H”3,l-benzoxazin-2-one as a colorless solid (4.7g, 21 mmol, 77percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 20712-12-3, (2-Amino-5-bromophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; SANOFI-AVENTIS; NAKAYAMA, Kazuki; SAKAI, Daiki; WATANABE, Kazutoshi; KOHARA, Toshiyuki; ARITOMO, Keiichi; WO2011/19090; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 20712-12-3 , The common heterocyclic compound, 20712-12-3, name is (2-Amino-5-bromophenyl)methanol, molecular formula is C7H8BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

b) Lambda/-[4-Bromo-2-(hydroxymethyI)phenyl]-2-chloroacetamideTo a suspension of Intermediate 28a (2.48 g) in dry Et2O (70 mL) at 00C was added dropwise a solution of chloroacetyl chloride (1.39 g) in dry toluene (25 mL). To the white suspension was added a solution of triethylamine (5.1 mL ) in dry toluene (25 mL). After 1 h the reaction mixture was treated with water and chloroform. The organic phase was dried, filtered, and concentrated in vacuo to give a brown oil (4.45 g) containing the title compound; ESMS m/z 278.0/280.0 [M+H]+ and the bis acetylated compound {5-bromo-2- [(chloroacetyl)amino]phenyl}methyl chloroacetate; ESMS m/z 352.0/354.0/356.0 [M+H]+

The synthetic route of 20712-12-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/50940; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 20712-12-3, (2-Amino-5-bromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 20712-12-3, blongs to alcohols-buliding-blocks compound. Safety of (2-Amino-5-bromophenyl)methanol

2-amino-5-bromobenzyl alcohol (4.04 g, 20.0 mmol) and diboron pinacol ester (7.65 g, 30.0 mmol, commercially available) were fully dissolved in 200 mL dioxane,Add CsCO3 (19.6 g, 60.0 mmol),PdCl2.dppf (0.88 g, 1.2 mmol) and dppf (0.55 g, 1.0 mmol),The reaction was heated at reflux.After 2 hours of reflux reaction, the reaction solution was cooled to room temperature.Insolubles are removed by filtrationEvaporate the solventResidue with water (200 ml),Extract with ethyl acetate (2 x 200 ml).The organic layer was washed with saturated saline solution.Dry with anhydrous magnesium sulfateConcentrate under reduced pressure,The residue was purified by column chromatography (eluent: EA_PE=1:3).3.39 g of a pale yellow solid.Yield 68.0percent

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20712-12-3, its application will become more common.

Reference:
Patent; Shenyang Sinochem Pesticide Chemical Research And Development Co., Ltd.; Li Bin; Wang Gang; Song Yuquan; Wu Shasha; Fan Xiaoxi; Shi Xuegeng; Yu Haibo; Lv Liang; (32 pag.)CN104650038; (2018); B;,
Alcohol – Wikipedia,
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Electric Literature of 20712-12-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 20712-12-3 as follows.

Step 2: Synthesis of 2-amino-5-bromobenzaldehyde A mixture of (2-amino-5-bromophenyl)methanol (10 g, 49.5 mmol) and Mn02 (25.8 g, 296.6 mmol) in CH2C12 (400 mL) was stuffed at RT overnight. LCMS showed the reaction was completed. The solid was filtered off, and the filtrate was concentrated to give the titlecompound as a light yellow solid (8 g, 8 1percent), which was directly used in next step without further purification. MS (ES+) C7H6BrNO requires: 199, found: 200, 202 [M + H].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20712-12-3, its application will become more common.

Reference:
Patent; BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.; WO2014/11900; (2014); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts