Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20603-00-3, name is 2-(Azepan-1-yl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks
General procedure: Method 2: To obtain target 3, alcohol 1 (1.25 mL, 9.30 mmol) was reacted with 2 (1 g, 9.30 mmol) in the presence of KOH (2.5 equiv, 1.30 g) in DMF (20 mL/g). The reaction mixture was allowed to stir overnight at room temperature. After completion, the crude reaction mixture was dissolved in H2O and extracted with Et2O. The product was then extracted into 6 M HCl from Et2O. The solution was basified to pH 12-13 with 5 M NaOH (aq) and extract with Et2O. The combined organic layers were washed with brine solution and dried over Na2SO4. After removal of the solvent under reduced pressure, the crude product was purified by column chromatography (silica gel, 5% CHCl3/MeOH/1% NH4OH) followed by formation of oxalate salt from ether.
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Reference:
Article; Stavitskaya, Lidiya; Shim, Jihyun; Healy, Jason R.; Matsumoto, Rae R.; MacKerell Jr., Alexander D.; Coop, Andrew; Bioorganic and Medicinal Chemistry; vol. 20; 14; (2012); p. 4556 – 4563;,
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