Category: 205877-13-0

Synthetic Route of 205877-13-0 ,Some common heterocyclic compound, 205877-13-0, molecular formula is C8H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 1.3g (5.9mmol) di-tert-butyl dicarbonate in 12mL anhydrous THF under N2 atmosphere, 0.83g (5.4mmol) (2-amino-3-methoxyphenyl)methanol31 was added and the resulting solution was stirred at 40C for 20h. The solvent was evaporated under reduced pressure and FCC with EtOAc and hexanes (1:3, Rf 0.6) gave 0.79g (3.1mmol, 58%) of 3c as a white solid. Mp: 112C. IR (ATR): 3463, 3361, 3274, 3016, 2924, 1686, 1531, 1158cm-1. 1H NMR (500MHz, CDCl3) delta=7.18-7.12 (m, 1H), 7.04 (dd, J=7.8, 1.3Hz, 1H), 6.79 (dd, J=8.3, 1.3Hz, 1H), 6.52 (br s, 1H), 4.50 (d, J=5.8Hz, 2H), 4.14 (br s, 1H), 3.77 (s, 3H), 1.49 (s, 9H). 13C NMR (126MHz, CDCl3) delta=155.8, 153.1, 137.9, 126.8, 124.0, 122.3, 110.0, 80.7, 61.8, 55.6, 28.1. MS (EI+): m/z calcd for (C13H19NO4) 253.1314, found 253.1327.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 205877-13-0, (2-Amino-3-methoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Popp, Tobias Alexander; Uhl, Edgar; Ong, Duc Nghia; Dittrich, Sebastian; Bracher, Franz; Tetrahedron; vol. 72; 13; (2016); p. 1668 – 1674;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 205877-13-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.205877-13-0, name is (2-Amino-3-methoxyphenyl)methanol, molecular formula is C8H11NO2, molecular weight is 153.1784, as common compound, the synthetic route is as follows.

General procedure: To a solution of 1a (1.2 g, 7.61 mmol) in CH2Cl2 (20 mL) was added MnO2 (2.6 g, 30.1 mmol) and stirred at rt under an Ar atmosphere. After 23 h with stirring, the reaction mixture was filtrated and evaporated. The residue was crystallized from AcOEt to give 7a (1.0 g, 85%) as a yellow needle crystal.

The chemical industry reduces the impact on the environment during synthesis 205877-13-0, I believe this compound will play a more active role in future production and life.

Reference:
Article; Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi; Bioorganic and Medicinal Chemistry; vol. 20; 19; (2012); p. 5810 – 5831;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 205877-13-0 ,Some common heterocyclic compound, 205877-13-0, molecular formula is C8H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A solution of 4-toluene sulfonyl chloride (4.58 g, 1.2 equiv) or methanesulfonyl chloride (1.9 mL, 1.2 equiv) and pyridine (2 mL, 1.3 equiv) in 20 mL CH2Cl2 was added slowly to the solution of compound 11 (0.02 mol) in 40 mL CH2Cl2. The mixture was stirred overnight at room temperature. Then 30 mL diluted HCl solution was added to the reaction mixture, the organic layer was separated using separating funnel. Subequently, the aqueous phase was extracted with 15 mL CH2Cl2 three times, the combined organic layers were washed separately with saturated NaHCO3 (30 mL) and saturated NaCl (30 mL) three times. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by column chromatography using petroleum ether/EtOAc = 1/1 to give the product 12.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,205877-13-0, its application will become more common.

Reference:
Article; Xu, Changrui; Wu, Zhengxing; Chen, Jianzhong; Xie, Fang; Zhang, Wanbin; Tetrahedron; vol. 73; 14; (2017); p. 1904 – 1910;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts