Category: 2043-47-2

Adding a certain compound to certain chemical reactions, such as: 2043-47-2, 1H,1H,2H,2H-Nonafluoro-1-hexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 1H,1H,2H,2H-Nonafluoro-1-hexanol, blongs to alcohols-buliding-blocks compound. Quality Control of 1H,1H,2H,2H-Nonafluoro-1-hexanol

Maleic anhydride (17.2 g, 176 mmol), lH,lH,2H,2H,-perfluorohexanol (93.1 g, 353 mmol), /?-toluenesulfonyl hydroxide (/?-TsOH) (3.4 g, 17.6 mmol) and toluene (50OmL) were heated to reflux for 8 h. An additional amount ofp- TsOH (3.4 g, 17.6 mmol) was added after 4 h of reflux. The solution was stirred overnight at room temperature. The solution was diluted with ethyl acetate (50OmL) and washed three times with brine (25OmL each). The combined extracts were washed with a further washing of ethyl acetate (30OmL). The combined organics were dried over anhydrous MgStheta4 and concentrated to yield a colorless oil (85.8 g, 80% yield, 98% purity). The structure of the product was confirmed by 1H NMR and LC/MS as di(lH,lH,2H,2H-perfluorohexyl) maleate.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2043-47-2, 1H,1H,2H,2H-Nonafluoro-1-hexanol, and friends who are interested can also refer to it.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; MURPHY, Peter, Michael; HEWAT, Tracy; WO2010/2623; (2010); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2043-47-2, Adding some certain compound to certain chemical reactions, such as: 2043-47-2, name is 1H,1H,2H,2H-Nonafluoro-1-hexanol,molecular formula is C6H5F9O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2043-47-2.

Example 14 Production of Exemplified Compound 126 {circle around (1)}: A solvent comprising 1.1 g of triethylamine and 5 g of toluene was added dropwise to a mixture comprising 2.47 g of 4-benzyloxybenzoic chloride (this compound was prepared from 4-benzyloxybenzoic acid and oxalyl chloride), 2.64 g of 2-n-perfluorobutylethanol and 10 g of toluene in 30 minutes. After finishing the adding dropwise, the mixture was stirred at room temperature for 6 hours. Deposited salts were filtered off, and the filtrate was neutralized with 1/2 N hydrochloric acid and washed with water. Then, toluene was distilled off under reduced pressure, and the resultant residue was recrystallized from methanol, whereby 3.3 g of 4-benzyloxybenzoic acid 2′-n-perfluorobutylethyl ester was obtained in the form of a colorless crystal.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2043-47-2, 1H,1H,2H,2H-Nonafluoro-1-hexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Mitsui Chemicals, Inc.; US6217793; (2001); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2043-47-2, name is 1H,1H,2H,2H-Nonafluoro-1-hexanol. A new synthetic method of this compound is introduced below., Recommanded Product: 1H,1H,2H,2H-Nonafluoro-1-hexanol

First, 26.4 g of 2-(perfluorobutyl)ethanol and 75 ml of dehydrated methylene chloride were put in a 200 ml flask provided with a calcium chloride tube, and cooled to 5 C. Then, 35.27 g of trifluoromethanesulfonic anhydride was dropped to the mixture while being stirred. Subsequently, 12.65 g of triethylamine was dropped to the mixture while being stirred. After the dropping, the resultant mixture was stirred for 24 hours. The resultant reaction solution was washed with 30 ml of water, further washed with 30 ml of 3% sulfuric acid, again washed with 30 ml of water, and dried with sodium sulfate. The solvent was then distilled off. The residue was distilled (b.p. 88 C. to 90 C./28 mmHg), to obtain 35.26 g (Y: 91.8%) of 2-(perfluorobutyl)ethyl trifluoromethanesulfonate. The purity of the resultant compound was 94.2% as measured by GC.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2043-47-2, 1H,1H,2H,2H-Nonafluoro-1-hexanol.

Reference:
Patent; Sharp Kabushiki Kaisha; Kanto Kagaku Kabushiki Kaisha; US6388146; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 2043-47-2, Adding some certain compound to certain chemical reactions, such as: 2043-47-2, name is 1H,1H,2H,2H-Nonafluoro-1-hexanol,molecular formula is C6H5F9O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2043-47-2.

Comparative Example 1In a 100-ml, three-necked glass reactor were placed 50 ml of methylene chloride, 10 g (38 mmol) of 3,3,4,4,5,5,6,6,6-nonafluorohexanol, 10 g (139 mmol) of acrylic acid, 0.1 g of a polymerization inhibitor, Sumilizer GM and 0.2 of toluenesulfonic acid. The mixture was heated. A reaction was allowed to proceed while distillation was made under normal pressure to remove the generated water together with methylene chloride. Every time when the amount of methylene chloride became small and the reactor-inside temperature exceeded 43 C., fresh methylene chloride was added into the reactor, to conduct the reaction for total 10 hours. At this point, the conversion was 82% and the selectivity was 84%.

According to the analysis of related databases, 2043-47-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOKUYAMA CORPORATION; DAIKIN INDUSTRIES, LTD.; US2009/23948; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 2043-47-2 ,Some common heterocyclic compound, 2043-47-2, molecular formula is C6H5F9O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 2In a 5-liter, four-necked glass reactor were placed 3 liters of methylene chloride, 7 g (69 mmol) of triethylamine, 81 g (764 mmol) of sodium carbonate, 100 g (379 mmol) of 3,3,4,4,5,5,6,6,6-nonafluorohexanol and 0.5 g of Sumilizer GM. Thereto was dropwise added 55 g (764 mmol) of acrylic acid. Then, 135 g (765 mmol) of benzenesulfonic acid chloride was added dropwise while the reaction temperature was kept at 40 C. or lower. After the completion of the dropwise addition, stirring was conducted at 30 C. for 2 hours to obtain a reaction mixture. At this point, the conversion was 88% and the selectivity was 99%. 400 ml of water was added to the reaction mixture. Stirring was conducted for 1 hour. Then, the reaction mixture was allowed to stand. An organic layer was separated from an aqueous layer. The organic layer was subjected to distillation under reduced pressure to remove methylene chloride. To the distillation residue obtained was added 2 liters of methylene chloride. There were further added 15 g (148 mmol) of triethylamine and 10 g (139 mmol) of acrylic acid. To the mixture was dropwise added 24 g (136 mmol) of benzenesulfonic acid chloride while the reaction temperature was kept at 40 C. or lower. After the completion of the dropwise addition, stirring was conducted for 2 hours while the temperature of reaction mixture was kept at 30 C. At this point, the conversion was 99% or more and the selectivity was 99%. 250 ml of water was added to the reaction mixture, followed by stirring for 30 minutes. The reaction mixture was allowed to stand. An organic layer was separated from an aqueous layer. The organic layer was washed two times each with 250 ml of water, after which the organic layer was subjected to distillation under reduced pressure to remove the methylene chloride contained therein. To the distillation residue obtained was added 0.5 g of a polymerization inhibitor, Sumilizer GM. The mixture was subjected to distillation under reduced pressure to obtain 101 g (317 mmol, yield: 84%) of 3,3,4,4,5,5,6,6,6-nonafluorohexyl acrylate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2043-47-2, its application will become more common.

Reference:
Patent; TOKUYAMA CORPORATION; DAIKIN INDUSTRIES, LTD.; US2009/23948; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2043-47-2 ,Some common heterocyclic compound, 2043-47-2, molecular formula is C6H5F9O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Mixing 5.00 parts of the salt represented by the formula (I-1-c) and 25 parts of chloroform;Stirred at 23 C. for 30 minutes.In the mixture obtained,1.09 parts of a compound represented by the formula (I-1-d) is added,Furthermore, it stirred at 50 degreeC for 2 hours.After cooling the resulting reaction mixture to 23 C.2.67 parts of a compound represented by formula (I-1-e) are added,Furthermore, it stirred at 23 degreeC for 18 hours. After adding 50 parts of chloroform and 50 parts of ion-exchanged water to the obtained reaction mixture and stirring for 30 minutes at 23 C., the layers were separated to take out the organic layer.In the organic layer obtained,After adding 25 parts of a 5% aqueous solution of oxalic acid and stirring at 23 C. for 30 minutes,The layers were separated and the organic layer was taken out.After adding 25 parts of ion-exchanged water to the obtained organic layer and stirring at 23 C. for 30 minutes,Separated and took out the organic layer. This water washing operation was repeated 5 times.After filtering the obtained organic layer,The filtrate is concentrated to a concentrated residue,By adding 30 parts of tert-butyl methyl ether and stirring at 23 C. for 30 minutes, the supernatant is removed and concentrated by4.39 parts of a salt represented by the formula (I-1) were obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2043-47-2, 1H,1H,2H,2H-Nonafluoro-1-hexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sumitomo Chemical Co., Ltd.; Komuro, Katsuhiro; Takahashi, Yuki; Ichikawa, Koji; (96 pag.)JP2019/59712; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts