Category: 2002-24-6

Application of 2002-24-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2002-24-6, name is 2-Aminoethanol hydrochloride, molecular formula is C2H8ClNO, molecular weight is 97.544, as common compound, the synthetic route is as follows.

9-(2′-hydroxyethylamino)-7-methoxy-4-methyl-1-nitroacridine 7-Methoxy-4-methyl-1 -nitro-9-phenoxyacridine (0.72 g) is dissolved in phenol (20 g). Ethanolamine hydrochloride (0.2 g) is added and the mixture is heated at 80 C. for 1.5 hour. The reaction mixture is cooled to room temperature, diluted with dry ether, slowly poured into dry ether (300 ml) and acidified with ethereal solution of hydrogen chloride. The resulting precipitate is filtered off, washed twice with ether and crystallized from absolute methanol to give 9-(2′-hydroxyethylamino)-7-methoxy-4-methyl-1-nitroacridine monohydrochloride as orange crystals (0.6 g, 86%), m.p. 200 C. (decomp.) 1H NMR (d6DMSO): delta2.60 (s, 3H, CH3), 3.50 (s, 4H, H-1′, H-2′), 4.00 (s, 3H, OCH3), 7.66 (dd, 1 H, J1=9.3 Hz, J2=2.5 Hz, H-6), 7.85 (d, 1 H, J =8.2 Hz, H-3), 8.02 (s, 1 H, H-8), 8.15 (d, 1 H, J =7.8 Hz, H-2), 8.22 (d, 1 H, J=7.8 Hz, H-5).

Statistics shows that 2002-24-6 is playing an increasingly important role. we look forward to future research findings about 2-Aminoethanol hydrochloride.

Reference:
Patent; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; Tiwari, Raj; US2002/99211; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2002-24-6, name is 2-Aminoethanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. 2002-24-6

9-(2′-hydroxyethylamino)-7-methoxy-1-nitroacridine 7-Methoxy-1-nitro-9-phenoxyacridine (0.69 g) is dissolved in phenol (20 g). Ethanolamine hydrochloride (0.2 g) is added and the mixture is heated at 100 C. for 1.5 hour. The reaction mixture is cooled to room temperature, diluted with dry ether (100 ml), slowly poured into dry ether (300 ml) and acidified with ethereal solution of hydrogen chloride. The resulting precipitate is filtered off, washed twice with ether and crystallized from absolute methanol-ether to give 9-(2′-hydroxyethylamino)-7-methoxy-1-nitroacridine monohydrochloride (0.58 g, 83% yield), m.p. 220 C. (decomp.) 1H NMR (d6DMSO): delta3.45 (t, 2 H, H-2′), 3.65 (t, 2 H, H-1′), 3.80 (s, 3 H, OCH3), 7.30 (dd, 1 H, J1=9.3 Hz, J2=2.5 Hz, H-6), 7.35 (d, 1 H, J=2.5 Hz, H-8), 7.40 (d, 1 H, J=9.3 Hz, H-5), 7.7 (m, 2 H, H-3, H-4), 7.87 (m, 1H, H-2).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2002-24-6, 2-Aminoethanol hydrochloride.

Reference:
Patent; Tiwari, Raj; Miller, Daniel G.; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; US2002/37831; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2002-24-6, name is 2-Aminoethanol hydrochloride, molecular formula is C2H8ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 2002-24-6

A mixture of crude 1- (3- {4- [3-CHLORO-4- (3-FLUORO-BENZYLOXY)-PHENYLAMINO]-QUINAZOLIN- 6-yl}-prop-2-ynyl)-2-phenyl-N-cyano-isourea (70 mg, 0.12 mmol) (from Step H, Example 1), 2- HYDROXYETHYLAMINE hydrochloride (39 mg, 0.4 mmol) and triethylamine (0.07 mL, 0.5 mmol) in isopropanol (2 mL) was heated to 85C in a sealed tube. The reaction was cooled to room temperature after 3 hours. Solvent was removed via rotovap. The residue was then purified by FCC to give the final product (25 mg, 38%) as a light yellow solid. MS ESI (+) m/z 544 (M+1) detected ; 1H NMR (400 MHz, deuterated DMSO) 9.95 (s, 1H), 8.7 (s, 1H), 8.6 (s, 1H), 8.05 (s, 1H), 8.0 (s, 1H), 7.8 (m, 1H), 7. 78 (M, 2H), 7.6 (br, 1H), 7. 5 (M, 1H), 7.22-7. 4 (M, 2H), 7.2 (M, 1H), 7.1 (M, 1H), 5.25 (s, 2H), 4.25 (m, 2H),-3. 5 (m, 2H), 3.25 (M, 2H).

The chemical industry reduces the impact on the environment during synthesis 2002-24-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ARRAY BIOPHARMA, INC.; WO2004/46101; (2004); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts