Synthetic Route of 1992-09-2, Adding some certain compound to certain chemical reactions, such as: 1992-09-2, name is 2-(4-Amino-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C10H9F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1992-09-2.
2.73 g of 2-(3′-methyl-4′-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanolCompound of formula VAnd 4.89 g of cesium carbonate was added to the dried reaction flask,Add in 20 ml of DMF and stir at room temperature for 30 minutes.1.70 g of methyl iodide was slowly added to the reaction flask with a syringe,Stirring was continued at room temperature and TLC was detected until the conversion of the starting material was complete.After the reaction was completed, it was extracted with a saturated aqueous solution of ammonium chloride and ethyl acetate.The organic phase was dried over anhydrous sodium sulfate and dried under reduced pressure.The crude oily intermediate VIa was obtained for subsequent reaction.
According to the analysis of related databases, 1992-09-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; East China University of Science and Technology; Cao Song; Zhao Xianghu; He Jingjing; Li Jialu; Liu Yisen; Li Chunmei; Xu Sixue; Huang Qingchun; (19 pag.)CN110272361; (2019); A;,
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