Category: 19819-98-8

Application of 19819-98-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19819-98-8, name is 2-(o-Tolyl)ethanol, molecular formula is C9H12O, molecular weight is 136.19, as common compound, the synthetic route is as follows.

General procedure: To a mixture of caffeic acid fine powder (1.0 g, 5.56 mmol, 1.0 equiv.),alcohol (5.56 mmol, 1.0 equiv.) in nitromethane (125 mL) was addedytterbium triflate (34.4 mg, 0.056 mmol, 0.01 equiv.). After 5 min inan ultrasonic bath the mixture without protective gas was stirred ona 120 C oil bath for a given time. The reaction mixture was cooled toroom temperature, washed with deionised water (30 mL), 2% NaHCO3(30 mL) and brine, dried over anhydrous Na2SO4 and evaporated underreduced pressure to give the crude product, which was purified on asilica gel column to give the compounds 1-5 and 8-30.

Statistics shows that 19819-98-8 is playing an increasingly important role. we look forward to future research findings about 2-(o-Tolyl)ethanol.

Reference:
Article; Xie, Dongsheng; Yang, Fengzhi; Xie, Jin; Zhang, Man; Liu, Wenlu; Fu, Lei; Journal of Chemical Research; vol. 38; 11; (2014); p. 695 – 700;,
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Synthetic Route of 19819-98-8 , The common heterocyclic compound, 19819-98-8, name is 2-(o-Tolyl)ethanol, molecular formula is C9H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 5 2-Methylphenethyl sulfamate A mixture of 2.65 g (0.019 mole) of 2-methylphenethyl alcohol in 10 ml DMF was added dropwise to a suspension of sodium hydride (1.1 g, 60% in oil; 0.08 mole) in 35 ml DMF at 0-5 C. The suspension was stirred for 20 min under argon after which sulfamoyl chloride (2.86 g, 0.02 mole) was added portion wise at 0-5 C. After stirring for 20 min the resultant suspension was poured into ice and extracted twice with Et2 O. The combined organic phases were washed with saturated brine, dried over potassium carbonate and concentrated in vacuo to a syrup which was purified by preparative HPLC with hexane/EtOAc (1:1, v/v) as the eluant to give 1.76 g (43%) of the title compound as a solid, mp 50-52 C. Elemental Analysis: Calculated for C9 H13 NO3 S: C, 50.22; H, 6.09; N, 6.51. Found: C, 50.40; H, 6.14; N, 6.43.

The synthetic route of 19819-98-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; McNeilab, Inc.; US4792569; (1988); A;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19819-98-8, name is 2-(o-Tolyl)ethanol, molecular formula is C9H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-(o-Tolyl)ethanol

General procedure: To a 1 dram vial equipped with a stir bar was added the alcohol (0.080 mmol), isopropyl (S)-2-(tert-butoxy)-2-(4?-(4,4-dimethylpiperidin- 1 -yl)-5-hydroxy-6?-methyl- [2,3?-bipyridinj-5?-yl)acetate (25 mg, 0.053 mmol), and triphenylphosphine (20.9 mg, 0.080 mmol) as a solution in THF (0.25 mL). To the solution was added DIAD (0.016 mL, 0.080 mmol) as a solution in THF (0.25 mL). The solution was stirred at r.t. for 30mm to 18 h. The reaction solution was concentrated under a N2 stream. The residue wasdissolved in EtOH (1.0 mL). To the solution was added aq. NaOH (5.0 M, 0.110 mL,0.532 mmol). The vial was capped, then placed in a 85 C heating block with stirring for4 h to 18 h. The mixture was cooled to r.t., then was filtered through a 0.4 micron syringefilter and the filtrate was directly subjected to HPLC purification to afford the purifiedproduct.

With the rapid development of chemical substances, we look forward to future research findings about 19819-98-8.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19819-98-8, name is 2-(o-Tolyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 19819-98-8

To a stirred solution of tert-butyl 4-([(5-chloro-2-hydroxybenzoyl)amino]methyl}benzoate (step 1 of the synthetic procedure of example 1-4, 0.21 g, 0.58 mmol), 2-(2-methylphenyl)ethanol (0.16 g, 1.2 mmol) and triphenylphosphine (0.30 g, 1.2 mmol) in tetrahydrofuran (5 mL) was added di-tert-butyl azodicarboxylate (0.27 g, 1.2 mmol) at room temperature. After being stirred overnight, the reaction was quenched by the addition of sodium bicarbonate aqueous solution. The aqueous layer was extracted with ethyl acetate and the combined organic layers were washed with brine, dried (magnesium sulfate), and evaporated. The remaining residue was purified by flush column chromatography on silica gel eluding with hexane/ethyl acetate (5/1) to afford 0.21 g (76%) of the title compounds as a colorless oil: 1H-NMR (CDCl3) 8.20 (1H, d, J=2.8 Hz), 7.99 (1H, t, J=5.9 Hz), 7.91 (2H, d, J=8.2 Hz), 7.38 (1H, dd, J=8.7, 2.8 Hz), 7.25 (2H, d, J=8.2 Hz), 7.16-7.03 (4H, m), 6.93 (1H, d, J=8.7 Hz), 4.52 (2H, d, J=5.9 Hz), 4.34 (2H, t, J=6.8 Hz), 3.04 (2H, t, J=6.8 Hz), 2.25 (3H, s), 1.59 (9H, s); MS (ESI) m/z 480 (M+H)+.

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Reference:
Patent; Pfizer Inc; US2005/250818; (2005); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19819-98-8, name is 2-(o-Tolyl)ethanol. A new synthetic method of this compound is introduced below., SDS of cas: 19819-98-8

The phenylacetaldehydes 6a-n were prepared by oxidation of the corresponding phenylethyl alcohols using dipyridine chromium (VI) oxide (Collin’s reagent) in dry dichloromethane at 25 C. according to reported procedures.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19819-98-8, 2-(o-Tolyl)ethanol.

Reference:
Patent; The Governors of the University of Alberta; US2011/9492; (2011); A1;,
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Alcohols – Chemistry LibreTexts