Electric Literature of 19812-64-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19812-64-7, name is Tetradecane-1,14-diol. A new synthetic method of this compound is introduced below.
Synthesis Example D-(25) 1,14-Tetradecandiol (1.5 g) was dissolved in 16.5 ml of cyclohexane, and 57% aqueous hydrobromic acid solution (16.5 ml) was added to this solution. The reaction mixture was refluxed for six hours while stirring. After the reaction, the mixture was extracted three times with diethyl ether. The organic layer was neutralized with saturated sodium hydrogen carbonate solution, washed with saline solution, dried over magnesium sulfate, and filtered, and the solvent was distilled off under reduced pressure. Purification of the residue by silica gel flash chromatography (hexane: ethyl acetate = 7:3) gave 14-bromotetradecan-1-ol as white crystals at a 67% yield. Molecular weight: 292.90 (C14H29BrO) TLC: (hexane-ethyl acetate 7-3) Rf value=0.53 1H-NMR: (300MHz, CDCl3) delta: 1.26 (s large, 20H, -(CH2)10-); 1.56 (qt, 2H, J=7.0Hz, -CH2-); 1.85 (qt, 2H, J=7.1Hz, -CH2-); 3.40 (t, 2H, J=6.9Hz, -CH2-Br); 3.64 (t, 2H, J=6.6Hz, -CH2-O-) 13C-NMR: (75MHz, CDCl3)delta: 25.72; 28.17; 28.75; 29.41-32.80; 32.82; 34.05; 63.08
At the same time, in my other blogs, there are other synthetic methods of this type of compound,19812-64-7, Tetradecane-1,14-diol, and friends who are interested can also refer to it.
Reference:
Patent; Meiji Dairies Corporation; EP1854777; (2007); A1;,
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