Category: 196811-90-2

Related Products of 196811-90-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 196811-90-2, name is 2-(4-(Trifluoromethoxy)phenyl)ethanol, molecular formula is C9H9F3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

MsCl (199 mg, 1.74 mmol) was added dropwise into a mixture of 2-[4- (trifluoromethoxy)phenyl]ethan-l-ol (300 mg, 1.46 mmol), dichloromethane (10 mL), and TEA (439 mg, 4.34 mmol) at 0C in 5 min under nitrogen. The resulting solution was stirred for 12h at room temperature and concentrated under vacuum. This resulted in the title compound (410 mg, crude) as a white solid

According to the analysis of related databases, 196811-90-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; PARAZA PHARMA, INC.; BEAUMIER, Francis; DERY, Martin; LAROUCHE-GAUTHIER, Robin; CHEN, Huifen; SHORE, Daniel; VILLEMURE, Elisia; VOLGRAF, Matthew; HU, Baihua; LU, Aijun; CRIDLAND, Andrew; WARD, Stuart; (212 pag.)WO2018/96159; (2018); A1;,
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Synthetic Route of 196811-90-2, Adding some certain compound to certain chemical reactions, such as: 196811-90-2, name is 2-(4-(Trifluoromethoxy)phenyl)ethanol,molecular formula is C9H9F3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 196811-90-2.

Intermediate 43 methyl(2-propyn-1-yl)(2-{4-[(trifluoromethyl)oxy]phenyl}ethyl)amine (N-methyI-N-(2-{4-[(trifluoromethyl)oxy]phenyl}ethyl)-2-propyn-1-amine). To a solution of Dess-Martin periodinane (1 ,1 ,1-tris(acetyloxy)-1 ,1-dihydro-1 ,2- benziodoxol-3-(1 H)-one) (ALDRICH, 3.79 g) in CH2CI2 (40 ml) was added a solution of Intermediate 42 (1.54 g) in CH2CI2 (40 ml) dropwise. The mixture was stirred at room temperature under inert atmosphere for 1 h. Then were added Et2O (30 ml), saturated NaHCO3 (25 ml) and saturated Na2S2O5 (25 ml), the resulting mixture was stirred for 25 min. The layers were separated and the aqueous one re-extracted with Et2O. The combined organic layers were washed with NaHCO3, H2O and brine, dried over Na2SO4, filtered and concentrated to dryness to give 1.067 g of yellow oil which was dissolved in dry CH3CN (50 ml). /V-methylpropargylamine (ALDRICH, 0.470 g), NaHB(AcO)3 (1.44 g), 3A molecular sieves and AcOH (1.6 ml) were added consecutively and the mixture stirred at room temperature under inert atmosphere overnight. Filtration through celite, washing with CH2Cb and evaporation of solvents gave a crude which was diluted with EtOAc and 1 N HCI. The aqueous layer was basified with 1 N NaOH and extracted with CH2CI2. The combined organic layers were dried over Na2SO4, filtered and concentrated to give 0.376 g of the title compound.1H NMR (delta, ppm, CDCI3): 7.23 (d, 2H); 7.13 (d, 2H); 3.41 (d, 2H); 2.81-2.66 (m, 4H); 2.37 (s, 3H); 1.70 (m, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 196811-90-2, 2-(4-(Trifluoromethoxy)phenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; BUENO-CALDERON, Jose Maria; FERNANDEZ-MOLINA, Jorge; LEON-DIAZ, Maria Luisa; MALLO-RUBIO, Araceli; MANZANO-CHINCHON, M Pilar; WO2010/81904; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts