Category: 19064-18-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19064-18-7, name is (2,6-Difluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C7H6F2O

A previously cooled to 0 C solution of 3.5 g (27.53 mmol) 2-fluoro-4-methoxy (CAS: 175965-83-0) and 3.97 g (27.53 mmol) of 2,6-difluorobenzyl alcohol in 97 ml of dry tetrahydrofuran was added dropwise with 27.5 ml (27.53 mmol) of a IM solution of potassium tert-butoxide in tetrahydrofuran.The obtained mixture was stirred for 18 hours at room temperature.The solvent was evaporated and the residue was partitioned between water and ethyl acetate.The organic phase was separated, washed with water and aqueous sodium chloride solution, dried over sodium sulfate, filtered and evaporated in vacuo to give 5.77 g (yield 66%, purity 79%) of the product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19064-18-7, (2,6-Difluorophenyl)methanol.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAF; VAKALOPOULOS, Alexandros; FOLLMANN, Markus; BUCHGRABER, Philipp; HARTUNG, Ingo; LINDNER, Niels; WUNDER, Frank; STASCH, Johannes-Peter; MARQUARDT, TOBIAS; REDLICH, Gorden; DIETZ, Lisa; LI, Volkhart Min-Jian; (391 pag.)TW2016/5850; (2016); A;,
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Application of 19064-18-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19064-18-7, name is (2,6-Difluorophenyl)methanol, molecular formula is C7H6F2O, molecular weight is 144.12, as common compound, the synthetic route is as follows.

4.86 g of potassium tert-butoxide (43.3 mmol, 3.0 eq.) were added to a solution of 2.71 g of (2,6-difluorophenyl)methanol [CAS No.: 19064-18-7] (18.8 mmol, 1.3 eq.) in 120 ml of 1,2-dimethoxyethane, and the mixture was stirred at RT for 60 min. 2.60 g of 2-amino-3-chloro-5-methylpyrazine hydrochloride [CAS No.: 89182-14-9] (14.4 mmol, 1.0 eq.) were then added, and the mixture was stirred at 80 C. overnight. After cooling to room temperature, saturated aqueous sodium bicarbonate solution was added and the aqueous phase was extracted three times with dichloromethane. The combined organic phases were washed with saturated aqueous sodium chloride solution, dried with magnesium sulfate, filtered and concentrated. The residue was purified by Biotage Isolera (340 g silica gel cartridge, cyclohexane/ethyl acetate gradient, 10%-72% ethyl acetate). This gave 1.77 g of the title compound (39% of theory, purity 85%). (0262) LC-MS (Method 2): Rt=0.94 min (0263) MS (ESpos): m/z=252 (M+H)+ (0264) 1H-NMR (400 MHz. DMSO-d6): delta [ppm]=2.20 (s, 3H), 5.35 (s, 2H), 5.88 (s, 2H), 7.09-7.23 (m, 2H), 7.37 (s, 1H), 7.46-7.57 (m, 1H).

Statistics shows that 19064-18-7 is playing an increasingly important role. we look forward to future research findings about (2,6-Difluorophenyl)methanol.

Reference:
Patent; Bayer Pharma Aktiengesellschaft; VAKALOPOULOS, Alexandros; BROCKSCHNIEDER, Damian; WUNDER, Frank; STASCH, Johannes-Peter; MARQUARDT, Tobias; DIETZ, Lisa; LI, Min Jian Volkhart; (30 pag.)US2018/22751; (2018); A1;,
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Electric Literature of 19064-18-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19064-18-7, name is (2,6-Difluorophenyl)methanol. A new synthetic method of this compound is introduced below.

Example 33 Preparation of 5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)-2-[2,6-difluorophenyl)methoxy]pyrimidine (62) To a solution of 2,6-difluorobenzyl alcohol (288 mg, 2 mmol) in 10 ml dry THF was added sodium hydride (80 mg, 60% mineral oil dispersion, 2 mmol). The resulting suspension was stirred at r.t. for 30 min before addition of 2,5-dibromopyrimidine (476 mg, 2 mmol). After stirred for 1 h at r.t. the reaction mixture was diluted with EA, worked up with aqueous sodium bicarbonate/brine. The organic phase was dried over sodium sulfate, concentrated, subjected to silica gel flash column using hexane and EA as eluents to give 290 mg 60 as white solid (yield: 48%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19064-18-7, (2,6-Difluorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; CalciMedica, Inc.; US2012/316182; (2012); A1;,
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Reference of 19064-18-7 ,Some common heterocyclic compound, 19064-18-7, molecular formula is C7H6F2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of (2,6-difluorophenyl)methanol (1 mL) and sodium hydride (60%, oil) (34 mg) was stirred at room temperature for 30 min. 3-(4-Chloropyridin-2-yl)quinazoline-2,4(1H,3H)-dione (115 mg) was added, and the obtained mixture was stirred at 150C for 4 hr. The reaction mixture was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (31 mg). 1H NMR (300 MHz, DMSO-d6) delta 5.24 (2H, s), 7.14-7.31 (6H, m), 7.51-7.65 (1H, m),7.66-7.79 (1H, m), 7.87-8.06 (1H, m), 8.45 (1H, d, J = 5.7 Hz), 11.65 (1H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19064-18-7, its application will become more common.

Reference:
Patent; Takeda Pharmaceutical Company Limited; OGINO, Masaki; IKEDA, Zenichi; FUJIMOTO, Jun; OHBA, Yusuke; ISHII, Naoki; FUJIMOTO, Takuya; ODA, Tsuneo; TAYA, Naohiro; YAMASHITA, Toshiro; MATSUNAGA, Nobuyuki; EP2889291; (2015); A1;,
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Application of 19064-18-7, Adding some certain compound to certain chemical reactions, such as: 19064-18-7, name is (2,6-Difluorophenyl)methanol,molecular formula is C7H6F2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19064-18-7.

To a solution of 2.71 g of (2,6-difluorophenyl)methanol [CAS No.: 19064-18-7] (18.8 mmol, 1.3 eq.) in 120 ml of 1,2-dimethoxyethane were added 4.86 g of potassium tert-butoxide (43.3 mmol, 3.0 eq.) and the mixture was stirred at RT for 60 min. Subsequently, 2.60 g of 2-amino-3-chloro-5-methylpyrazine hydrochloride [CAS No.: 89182-14-9] (14.4 mmol, 1.0 eq.) were added and the mixture was stirred at 80 C. overnight. After cooling to room temperature, saturated aqueous sodium hydrogencarbonate solution was added and the aqueous phase was extracted three times with dichloromethane. The combined organic phases were washed with saturated aqueous sodium chloride solution, dried with magnesium sulphate, filtered and concentrated. The residue was purified by means of Biotage Isolera (340 g silica gel cartridge, cyclohexane/ethyl acetate gradient, 10%->72% ethyl acetate). 1.77 g of the title compound were obtained (39% of theory; 85% purity). (0942) LC-MS (Method 2): Rt=0.94 min (0943) MS (ESpos): m/z=252 (M+H)+ (0944) 1H-NMR (400 MHz, DMSO-d6): delta [ppm]=2.20 (s, 3H), 5.35 (s, 2H), 5.88 (s, 2H), 7.09-7.23 (m, 2H), 7.37 (s, 1H), 7.46-7.57 (m, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 19064-18-7, (2,6-Difluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; VAKALOPOULOS, Alexandros; FOLLMANN, Markus; HARTUNG, Ingo; BUCHGRABER, Philipp; JAUTELAT, Rolf; LINDNER, Niels; WUNDER, Frank; STASCH, Johannes-Peter; REDLICH, Gorden; Dietz, Lisa; LI, Volkhart Min-Jian; (85 pag.)US2016/176880; (2016); A1;,
Alcohol – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19064-18-7, name is (2,6-Difluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Safety of (2,6-Difluorophenyl)methanol

(b) 13.0 g of 2,6-difluorobenzyl alcohol and 8.4 g of methanesulphonyl chloride are dissolved in 90 ml of methylene chloride, and 17.6 ml of triethylamine in 18 ml of methylene chloride are added dropwise while stirring in an ice bath. The rate at which the triethylamine is added is so regulated that the internal temperature does not exceed 10. The whole is stirred for a further 40 minutes in the ice bath and then 90 ml of ice-water are added and the whole is stirred for a further 60 minutes. The organic phase is separated off and dried over magnesium sulphate, and 21 g of the monosodium salt of imidazole-4,5-dicarboxylic acid diethyl ester (obtainable, for example, by reacting imidazole-4,5-dicarboxylic acid diethyl ester with 2.53 g of sodium dissolved in 60 ml of ethanol) are added. The whole is stirred for 3 hours at room temperature, washed three times with water, dried over magnesium sulphate, concentrated to dryness by evaporation, dissolved in toluene/ethyl acetate (1:1), filtered over silica gel, again concentrated to dryness by evaporation and recrystallized from ether/petroleum ether. 1-(2,6-difluorobenzyl)-imidazole-4,5-dicarboxylic acid diethyl ester having a melting point of 68-70 is obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19064-18-7, (2,6-Difluorophenyl)methanol.

Reference:
Patent; Ciba-Geigy Corporation; US4851424; (1989); A;,
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Application of 19064-18-7 ,Some common heterocyclic compound, 19064-18-7, molecular formula is C7H6F2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

15.5 ml (15.5 mmol) of a 1M solution of potassium tert-butoxide in tetrahydrofuran at 0 C was added to a solution of 1.72 ml (15.5 mmol) (2,6-difluorophenyl) methanol and 1.6 ml (15.5 mmol) 4-bromo-2-fluoropyridine in 50 ml of anhydrous tetrahydrofuran.The reaction mixture was stirred at room temperature for 18 h.It was partitioned between ethyl acetate and water.The organic phase was separated and washed with water and saturated aqueous sodium chloride solution, dried, filtered and concentrated over sodium sulfate.The residue was purified by chromatography on silica gel (40 g silica gel cartridge, mobile phase: cyclohexane / ethyl acetate, gradient 0% to 100%) purified.This gave 4.12 g of the target compound (88% d. Th.).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 19064-18-7, (2,6-Difluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAF; VAKALOPOULOS, Alexandros; FOLLMANN, Markus; BUCHGRABER, Philipp; HARTUNG, Ingo; LINDNER, Niels; WUNDER, Frank; STASCH, Johannes-Peter; MARQUARDT, TOBIAS; REDLICH, Gorden; DIETZ, Lisa; LI, Volkhart Min-Jian; (391 pag.)TW2016/5850; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 19064-18-7, (2,6-Difluorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 19064-18-7, blongs to alcohols-buliding-blocks compound. Product Details of 19064-18-7

Example 124 (R)-2,6-Difluorobenzyl 2-methylpiperazine-1-carboxylate hydrochloride was prepared from 2,6-difluorobenzyl alcohol and (R)1-chlorocarbonyl-2-methyl-4-tert-butoxycarbonylpiperazine according to the methods described for Examples 52 and 54 to give the product as a white solid (0.217 g, 70% overall); (Found: C, 50.7; H, 5.65; N, 9.0. C13H16F2N2O2.HCl requires C, 50.9; H, 5.6; N, 9.1%); deltaH (400 MHz, DMSO-d6) 9.39 (2H, br), 7.50 (1H, m), 7.18-7.12 (2H, m), 5.17 (2H, m, J 12.4 Hz), 4.29 (2H, m), 3.88 (1H, d, J 13 Hz), 3.24-3.03 (4H, m, J 13 Hz), 2.86 (1H, m, J 12.4 Hz), and 1.24 (3H, d, J 7.2 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19064-18-7, its application will become more common.

Reference:
Patent; Adams, David Reginald; Bentley, Jonathan Mark; Davidson, James Edward Paul; Dawson, Claire Elizabeth; George, Ashley Roger; Mansell, Howard Langham; Mattei, Patrizio; Mizrahi, Jacques; Nettekoven, Matthias Heinrich; Pratt, Robert Mark; Roever, Stephan; Roffey, Jonathan Richard Anthony; Specklin, Jean-Luc; Stalder, Henri; Wilkinson, Kerry; US2002/143020; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19064-18-7, name is (2,6-Difluorophenyl)methanol, molecular formula is C7H6F2O, molecular weight is 144.12, as common compound, the synthetic route is as follows.Product Details of 19064-18-7

A solution of 2 ml (18.0 mmol) (2,6-difluorophenyl) methanol in 15 ml at 0 C stirred dry tetrahydrofuran was treated with 865.9 mg (6.21 mmol) of sodium hydride (60% in mineral oil), followed by 1.72 ml (18.0 mmol) of 2-bromopyridine.The solution was stirred at room erature for 15 hours.The reaction mixture was diluted (15 ml) with water and extracted with dichloromethane (2 x 20 ml).The organic phase was separated, dried with a phase separation cartridge, and concentrated in vacuo.The residue was purified by flash chromatography using a prepacked silica gel cartridge purified, yielding 800 mg of the target compound (eluent: 1 cyclohexane-ethyl acetate 10: 1 to 1) (15% of theory, 77%. purity).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19064-18-7, (2,6-Difluorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAF; VAKALOPOULOS, Alexandros; FOLLMANN, Markus; BUCHGRABER, Philipp; HARTUNG, Ingo; LINDNER, Niels; WUNDER, Frank; STASCH, Johannes-Peter; MARQUARDT, TOBIAS; REDLICH, Gorden; DIETZ, Lisa; LI, Volkhart Min-Jian; (391 pag.)TW2016/5850; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 19064-18-7, (2,6-Difluorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (2,6-Difluorophenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (2,6-Difluorophenyl)methanol

3-(4-N,N-dimethylaminomethyl)phenyl-2-chloro-6-bromoquinoline(60 mg, 0.16 mmol) was dissolved in 2 mL of anhydrous tetrahydrofuran,Followed by addition of 2,6-difluorobenzyl alcohol (46 mg, 0.32 mmol),60% sodium hydride (30 mg, 0.78 mmol) was added and the reaction was stirred at room temperature for 8 hours.The organic phases were combined, concentrated to dryness and chromatographed on a column (dichloromethane / methanol 25: 1), dried over MgSO4,To give 63 mg of a pale yellow oil in 81.68% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19064-18-7, (2,6-Difluorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Institute of Materia Medica,Chinese Academy of Medical Sciences; He, Chunxian; Cui, Huaqing; Yin, Dali; (66 pag.)CN106167464; (2016); A;,
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