Category: 18621-18-6

In 2011,Shi, Ying; Zhang, Ya-ran; Di, Hui-feng; Jia, Ming; Zhang, Zhi-bao published 《Synthesis of 3-mercapto-1-(1,3-thiazolin-2-yl)azetidine hydrochloride》.Huaxue Shiji published the findings.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

3-Mercapto-1-(1,3-thiazolin-2-yl) azetidine hydrochloride has been synthesized from 2-mercaptothiazoline, through methylation, SN2 nucleophilic substitution with 3-hydroxyazetidine hydrochloride, activation of the hydroxyl group with methanesulfonyl chloride, SN2 nucleophilic substitution of the resultant mesylate with potassium thioacetate, and basic hydrolysis. The total yield was 51.6%, and purity of product was 98.5%. The method features mild conditions, easy manipulation, high purity and suitability for industrialization.Azetidin-3-ol hydrochloride(cas: 18621-18-6Category: alcohols-buliding-blocks) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Category: alcohols-buliding-blocks Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2013,Wang, Jie; Zhu, Xiao-hua; Chen, Guo-hua published 《Process improvement on the synthesis of 3-mercapto-1-(1, 3-thiazolin-2-yl) azetidine hydrochloride》.Hecheng Huaxue published the findings.Formula: C3H8ClNO The information in the text is summarized as follows:

A key intermediate of Tebipenem pivoxil, 3-mercapto-1-(1, 3-thiazolin-2-yl) azetidine hydrochloride, was synthesized from benzylamine by N-alkylation, cyclization, catalytic hydrogenation, N-protection, mesylation, SN2 substitution, hydrolysis, and condensation. The overall yield was 40%. The structure was confirmed by 1H NMR, IR and MS. The experimental process involved the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Formula: C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Formula: C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Computed Properties of C3H8ClNOIn 2019 ,《tert-Butylphenylthiazoles with an oxadiazole linker: a novel orally bioavailable class of antibiotics exhibiting antibiofilm activity》 was published in RSC Advances. The article was written by Kotb, Ahmed; Abutaleb, Nader S.; Hagras, Mohamed; Bayoumi, Ashraf; Moustafa, Mahmoud M.; Ghiaty, Adel; Seleem, Mohamed N.; Mayhoub, Abdelrahman S.. The article contains the following contents:

The structure-activity and structure-kinetic relationships of a new tert-butylphenylthiazole series with oxadiazole linkers were conducted with the objective of obtaining a new orally available antibacterial compounds Twenty-two new compounds were prepared, purified and identified. Their activity against methicillin-resistant Staphylococcus aureus were examined Compound 20 with 3-hydroxyazetidine as a nitrogenous side chain showed promising activity against twenty-four clin. isolates, including vancomycin-resistant staphylococcal and enterococcal species with MIC values ranging from 4-8 μg mL-1. Addnl. advantages of this compound include an ability to eradicate staphylococcal biofilm mass in a dose-dependent manner as well as high metabolic stability after an oral dose of 25 mg kg-1 with a biol. half-life that exceeds 5 h and a plasma concentration (Cmax) that exceeds the MIC values. In addition to this study using Azetidin-3-ol hydrochloride, there are many other studies that have used Azetidin-3-ol hydrochloride(cas: 18621-18-6Computed Properties of C3H8ClNO) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Computed Properties of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Han; Chen, Zhen; Guo, Wenjing; Gu, Zhenhua published an article in 2022. The article was titled 《Synthesis of 2-Aryl Azetidines through Pd-Catalyzed Migration/Coupling of 3-Iodoazetidines and Aryl Boronic Acidsã€? and you may find the article in Organic Letters.Synthetic Route of C3H8ClNO The information in the text is summarized as follows:

A palladium-catalyzed cross-coupling of 3-iodoazetidines and nonheteroaryl boronic acids was reported. The [1,1′-biphenyl]-2-yldicyclohexylphosphane ligand enabled the reaction that favored the formation of 2-aryl azetidines. The control experiments indicated that the reaction can proceed through either a palladium-hydride/dihydroazete complex or free dihydroazete intermediate followed by hydropalladation.Azetidin-3-ol hydrochloride(cas: 18621-18-6Synthetic Route of C3H8ClNO) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Synthetic Route of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Meuser, Megan E.; Murphy, Michael B.; Rashad, Adel A.; Cocklin, Simon published 《Kinetic characterization of novel HIV-1 entry inhibitors: discovery of a relationship between off-rate and potencyã€?Molecules published the findings.Safety of Azetidin-3-ol hydrochloride The information in the text is summarized as follows:

The entry of HIV-1 into permissible cells remains an extremely attractive and underexploited therapeutic intervention point. We have previously demonstrated the ability to extend the chemotypes available for optimization in the entry inhibitor class using computational means. Here, we continue this effort, designing and testing three novel compounds with the ability to inhibit HIV-1 entry. We demonstrate that alteration of the core moiety of these entry inhibitors directly influences the potency of the compounds, despite common proximal and distal groups. Moreover, by establishing for the first time a surface plasmon resonance (SPR)-based interaction assay with soluble recombinant SOSIP Env trimers, we demonstrate that the off-rate (kd) parameter shows the strongest correlation with potency in an antiviral assay. Finally, we establish an underappreciated relationship between the potency of a ligand and its degree of electrostatic complementarity (EC) with its target, the Env complex. These findings not only broaden the chem. space in this inhibitor class, but also establish a rapid and simple assay to evaluate future HIV-1 entry inhibitors. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Safety of Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Safety of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Richter, Adrian; Narula, Gagandeep; Rudolph, Ines; Seidel, Ruediger W.; Wagner, Christoph; Av-Gay, Yossef; Imming, Peter published an article in ChemMedChem. The title of the article was 《Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosisã€?Recommanded Product: Azetidin-3-ol hydrochloride The author mentioned the following in the article:

8-Nitrobenzothiazinones (BTZs) were a promising class of antimycobacterial agents currently under investigation in clin. trials. Starting from thiourea derivatives, a new synthetic pathway to BTZs was established. It allows the formation of the thiazinone ring system in one synthetic step and was applicable for preparation of a wide variety of BTZ analogs. The synthetic procedure furthermore facilitates the replacement of the sulfur atom in the thiazinone ring system by oxygen or nitrogen to afford the analogous benzoxazinone and quinazolinone systems. 36 BTZ analogs were prepared and tested in luminescence-based assays for in vitro activity against Mycobacterium tuberculosis (Mtb) using the microdilution broth method and a high-throughput macrophage infection assay. The experimental part of the paper was very detailed, including the reaction process of Azetidin-3-ol hydrochloride(cas: 18621-18-6Recommanded Product: Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Recommanded Product: Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2012,Ishida, Naoki; Yuhki, Tatsuya; Murakami, Masahiro published 《Synthesis of Enantiopure Dehydropiperidinones from α-Amino Acids and Alkynes via Azetidin-3-ones》.Organic Letters published the findings.Application of 18621-18-6 The information in the text is summarized as follows:

Chiral dehydropiperidinones were synthesized in enantiopure form from α-amino acids and alkynes via nickel-catalyzed insertion into azetidin-3-one intermediates. After reading the article, we found that the author used Azetidin-3-ol hydrochloride(cas: 18621-18-6Application of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Cai, Wangshui; Wang, Shuang; Jalani, Hitesh B.; Wu, Junxian; Lu, Hongjian; Li, Guigen published 《Oxidative Cascade Reaction of N-Aryl-3-alkylideneazetidines and Carboxylic Acids: Access to Fused Pyridines》.Organic Letters published the findings.Application of 18621-18-6 The information in the text is summarized as follows:

A versatile silver-promoted oxidative cascade reaction of N-aryl-3-alkylideneazetidines with carboxylic acids is reported, providing a very efficient pathway to functionalized fused pyridines. This method allows introduction of fused pyridine ring systems to heterocycles, drugs, and natural products. A mechanistic study revealed that silver salt is essential for the chemo- and regioselective ring expansion, sequential oxidative nucleophilic additions, and oxidative aromatization. This approach represents the first example of the strained N-heterocycles undergoing a cascade reaction with a π bond and a nucleophile together.Azetidin-3-ol hydrochloride(cas: 18621-18-6Application of 18621-18-6) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Product Details of 18621-18-6In 2018 ,《Multiheterocyclic Motifs via Three-Component Reactions of Benzynes, Cyclic Amines, and Protic Nucleophilesã€?appeared in Organic Letters. The author of the article were Ross, Sean P.; Hoye, Thomas R.. The article conveys some information:

A broadly general, three-component reaction strategy for the construction of compounds containing multiple heterocycles is described. Thermal benzyne formation (by the hexadehydro-Diels-Alder (HDDA) reaction) in the presence of tertiary cyclic amines and a protic nucleophile (HNu) gives, via ring-opening of intermediate ammonium ion/Nu- ion pairs, heterocyclic products. Many reactions are efficient even when the stoichiometric loading of the three reactants approaches unity. Use of HOSO2CF3 as the HNu gives ammonium triflate intermediates, which can then be ring opened by an even wider variety of nucleophiles. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Product Details of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Product Details of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Li, Xinwei; Bian, Jiqing; Fu, Mingyang; Zhang, Yan; Liu, Hongmei; Gao, Baoxiang published an article in Analytical Methods. The title of the article was 《Photostable fluorescent probes based on multifunctional group substituted naphthalimide dyes for imaging of lipid droplets in live cellsã€?SDS of cas: 18621-18-6 The author mentioned the following in the article:

We designed and synthesized multifunctional group substituted naphthalimide (MFGNI) dyes by introducing glycine Et ester and azetidine on 1,8-naphthalimide. With different azetidine substituents, the emission of the MFGNI dyes was shifted from blue to green. These MFGNI dyes exhibited high photoluminescence quantum yields (61% to 85%) and large Stokes shifts (67 nm). The amides and hydroxyl groups improved the photostability of the MFGNI dyes. Due to the small mol. weight and lipophilic properties, these MFGNI dyes specifically stained lipid droplets in living cells. After reading the article, we found that the author used Azetidin-3-ol hydrochloride(cas: 18621-18-6SDS of cas: 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.SDS of cas: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts