Category: 18385-82-5

Application of 18385-82-5, Adding some certain compound to certain chemical reactions, such as: 18385-82-5, name is 7-Bromochroman-4-ol,molecular formula is C9H9BrO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18385-82-5.

To a solution of 7-Bromochroman-4-ol (Prepared as described in U52013/18055)(0.64g, 2.78 mmol), tert-Butyl 4-(2-hydroxy-5-(trifluoromethyl)phenyl)piperidine- 1 -carboxylate (Intermediate-iS) (0.80g, 2.3 16 mmol) and triphenylphosphine (0.91g, 3.47 mmol) in THF (25 ml) was added DIAD (0.901 ml, 4.63 mmol) stined at room temperature for 16h. Reaction mixture was diluted with ethyl actate and washed with aqueous NaOH solution, brine, dried over Na2SO4 and evaporated. The crude product was purified by flash column chromatography( 10% ethyl acetate/Petroleum ether) to obtain title compound(0.5g, 39 %). LCMS(ESI):m/z 578.12 (M+Na).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18385-82-5, 7-Bromochroman-4-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LUPIN LIMITED; RAMDAS, Vidya; LORIYA, Rajeshkumar, Maganlal; WALKE, Deepak, Sahebrao; DAS, Amit, Kumar; KHAN, Talha, Hussain; BANERJEE, Moloy; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; (187 pag.)WO2015/151001; (2015); A1;,
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Related Products of 18385-82-5, Adding some certain compound to certain chemical reactions, such as: 18385-82-5, name is 7-Bromochroman-4-ol,molecular formula is C9H9BrO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18385-82-5.

[0332j A solution of 7-bromochroman-4-ol (200 mg, 0.88 mmol, 1.0 equiv) in toluene (5 mL) was cooled in an ice bath under N2 and treated with DPPA (532 mg, 1.93 mmol, 2.2 equiv) in one portion followed by DBU (293 mg, 1.93 mmol, 2.2 equiv). The reaction temperature was kept at 0 C for 1 h and then was warmed to room temperature for 16 h. The mixture was diluted with EtOAc (50 mL), washed with 2N HC1 (2 x 30 mL), brine and the organic layer was dried over Na2504, filtered then concentrated. The crude product was purified by silica gel column (eluted with PE). 4-azido-7-bromochroman (188 mg, yield: 90%) was obtained as a white solid. ?H NMR (400 MHz, CDC13) 5: 7.07-7.06 (m, 3H), 4.56 (t, J= 3.6 Hz, 1H), 4.30-4.17 (m, 2H), 2.19-1.99 (m, 2H).

According to the analysis of related databases, 18385-82-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; MA, Bin; CHAN, Timothy, Raymond; SUN, Lihong; ZHANG, Lei; KUMARAVEL, Gnanasambandam; LYSSIKATOS, Joseph, P.; KOCH, Kevin; MIAO, Hua; WO2015/89337; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 18385-82-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 18385-82-5, name is 7-Bromochroman-4-ol. This compound has unique chemical properties. The synthetic route is as follows.

7-bromochaoman-4-ol (8.80 mmol, crude), TBSCl (1.64 g, 10.5 mmol), and imidazole (1.80 g, 26.4 mmol) were stirred in DCM (17 mL) at r.t. After 16h the reaction was quenched by the addition of water (100 mL) and DCM (100 mL). The organic layer was removed and the aqueous layer was extracted with DCM (2 x 100 mL). The combined organic fractions were dried with Na2SO4 and concentrated. The crude product was purified by column chromatography to provide ((7-bromochroman-4-yl)oxy)(tert-butyl)dimethylsilane (2.9 g, 96%). mlz 375.0 [M+MeOH+H]+, 1H NMR (400 MHz, Chloroform-d) 7.05 (d, J = 8.0 Hz, 1H), 7.02 – 6.94 (m, 2H), 4.74 (t, J = 4.6Hz, 1H), 4.31 (ddd, J 10.9, 9.6, 3.0 Hz, 1H), 4.20 (ddd, J = 10.9, 5.7, 3.6 Hz, 1H), 2.11 – 1.88 (m,2H), 0.90 (s, 9H), 0.15 (s, 3H), 0.13 (s, 3H).

According to the analysis of related databases, 18385-82-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; XENON PHARMACEUTICALS INC.; BERGERON, Phillipe; BURFORD, Kristen; CHOWDHURY, Sultan; DEHNHARDT, Christoph Martin; FOCKEN, Thilo; GRIMWOOD, Michael Edward; HASAN, Abid; LAI, Kwong Wah; LIU, Zhiguo; MCKERRALL, Steven; NGUYEN, Teresa Phuongtram; SAFINA, Brian; SUTHERLIN, Daniel; TAN, Wang Tao; (470 pag.)WO2017/58821; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts