Category: 1805-32-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 1805-32-9

General procedure: The alcohol (1 mmol) was added to a mixture of TBHP(1 mmol) and VO(ephedrine)2MNPs (50 mg) in PEG(1 mL), and then the mixture was refluxed at 80 C for thetime specified. The progress was monitored by TLC (EtOAc/n-hexane, 1/2). After completion of the reaction, the catalystwas separated from the product by an external magnet(within 5 s), and the mixture was washed with EtOAc(25 mL) and decanted. The decanted mixturewas washedwith 30% NaOH (5 mL) and the organic layer was dried overanhydrous Na2SO4. The evaporation of EtOAc underreduced pressure gave the pure products in 85e98% yields.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1805-32-9, 3,4-Dichlorobenzyl alcohol.

Reference:
Article; Rostami, Amin; Pourshiani, Omid; Darvishi, Neda; Atashkar, Bahareh; Comptes Rendus Chimie; vol. 20; 4; (2017); p. 435 – 439;,
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Application of 1805-32-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of the substrate (1 mmol), hexamethyldisilazane (0.70 mmol), and/or 3,4-dihydro-2H-pyran (1.4 mmol) and BiPy(SO3H)2(HSO4)2 (10 mg, 1.95 mol%) in CH3CN(3 mL) and/or CH2Cl2 (3 mL) was stirred at room temperature. The progress of thereaction was monitored by TLC (n-hexane: EtOAc; 10:1) and/or GC. After completion ofthe reaction, the mixture was filtered to separate the solid catalyst. Then the solution wasfiltered through a silica gel pad and washed with CH3CN (2 × 3 mL) and/or CH2Cl2 (2 ×3 mL). Evaporation of the solvent gave the desired products in high purity.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1805-32-9, 3,4-Dichlorobenzyl alcohol.

Reference:
Article; Shirini, Farhad; Abedini, Masoumeh; Mahmoodi, Nosratollah; Biglari, Mohammad; Safarpoor Nikoo Langrudi, Mohaddeseh; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 190; 11; (2015); p. 1912 – 1921;,
Alcohol – Wikipedia,
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Electric Literature of 1805-32-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1805-32-9, name is 3,4-Dichlorobenzyl alcohol, molecular formula is C7H6Cl2O, molecular weight is 177.03, as common compound, the synthetic route is as follows.

General procedure: A mixture of the substrate (1 mmol), dimethoxymethane(DMM) (4 mmol) and PC-NPs (12 mg) was stirred at room temperature for the appropriate time. The progress of the reaction was monitored by TLC (EtOAc: n-hexane; 1:1). After completion of the reaction, the mixture was filtered,and the solid residue was washed with Et2O (5 mL). The filtrate was washed with a saturated solution of NaHCO3 and H2O and dried over MgSO4. Evaporation of the solvent afforded the requested methoxymethyl (MOM) ether in high purity.

The chemical industry reduces the impact on the environment during synthesis 1805-32-9, I believe this compound will play a more active role in future production and life.

Reference:
Article; Shirini, Farhad; Fallah-Shojaei, Abdollah; Abedini, Masoumeh; Samavi, Laleh; Journal of the Iranian Chemical Society; vol. 13; 9; (2016); p. 1699 – 1712;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 1805-32-9 ,Some common heterocyclic compound, 1805-32-9, molecular formula is C7H6Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of alcohol (1mmol) in 2mL of toluene was added GO (0.3g). The resulting mixture was sonicated in an Elmasonic P ultrasonic cleaning unit (ultrasonic bath) with a frequency of 37kHz and 100% output power at 80C for the time indicated in Table 4. Then Oxone (1mmol) and 2mL of an alcoholic solvent was added in the reaction medium and the resulting mixture was irradiated for the time indicated in Table 4. The mixture was filtered through a sintered funnel and evaporated under reduced pressure, and extracted with ethyl acetate. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. Purification was achieved by column chromatography using n-hexane/EtOAc: 100/3 as eluent. The spectroscopic data of the obtained esters were compared with authentic samples [5,40,42,43]. Spectroscopic data for methyl 3,4-dichlorobenzoate (entry 9, Table 4): Pale yellow, M.P. 44.7C; IR (KBr) nu=3089, 3022, 2958, 1729, 1589, 1435, 1378, 1301, 1110, 757cm-1; 1H NMR (300MHz, CDCl3) delta=3.94 (s, 3H, CH3), 7.53 (d, J=8.3Hz, 1H, CH Arom), 7.87 (dd, J=8.3, 1.9Hz, 1H, CH Arom), 8.13 (d, J=1.9Hz, 1H, CH Arom); 13C NMR (75MHz, CDCl3) delta=52.54, 128.63, 129.94, 130.52, 131.53, 132.92, 137.56, 165.21; MS (EI) (70eV), m/z (%): 208 (5) [M+4]+, 206 (31) [M+2]+, 204 (50) [M]+, 177 (10), 175 (62), 173 (100), 145 (30), 109 (20), 74 (18).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1805-32-9, its application will become more common.

Reference:
Article; Mirza-Aghayan, Maryam; Zonoubi, Somayeh; Molaee Tavana, Mahdieh; Boukherroub, Rabah; Ultrasonics Sonochemistry; vol. 22; (2015); p. 359 – 364;,
Alcohol – Wikipedia,
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Related Products of 1805-32-9 ,Some common heterocyclic compound, 1805-32-9, molecular formula is C7H6Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a 50 mL Schlenk tube equipped with a stir bar was added 0.5 mmol of benzylic alcohol followed by 0.05 mmol of CuF2 (0.1 equiv). The mixture of DMSO (1.5 mL) and H2O (1.5 mL) was added, followed by 6 mmol of TBHP(12 equiv). The glass tube was vacuumed and purged with argon three times before it was tightly screw-capped. The reaction mixture was stirred at 120 Cfor 12 h, cooled to room temperature, poured into brine and extracted with EtOAc. The combined extracts were dried over MgSO4, filtered, and evaporated. The residue was purified by column chromatography (petroleumether/EtOAc) to afford the methyl ester

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1805-32-9, 3,4-Dichlorobenzyl alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Pan; Zhao, Jingjing; Lang, Rui; Xia, Chungu; Li, Fuwei; Tetrahedron Letters; vol. 55; 2; (2014); p. 390 – 393;,
Alcohol – Wikipedia,
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Electric Literature of 1805-32-9, Adding some certain compound to certain chemical reactions, such as: 1805-32-9, name is 3,4-Dichlorobenzyl alcohol,molecular formula is C7H6Cl2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1805-32-9.

Example 32; (3,4-Dichlorophenyl)methyl 2-cyanopyrazolidine-1 -carboxylate (32)(3,4-Dichlorophenyl)methyl chloroformate was prepared by dissolving 3,4-dichlorobenzyl alcohol (122.0 mg, 0.69 mmol) was in 3 mL dichloromethane followed by diisopropylethylamine (145 uL, 0.83 mmol). 20% Phosgene in toluene (473 uL, 0.83 mmol) was added dropwise and the reaction mixture was allowed to stir at room temperature for 2 hours. 4 was prepared according to Example 4. To this was added the 3,4- (dichlorophenyl)methyl chloroformate in one portion and the reaction mixture was stirred overnight at room temperature. After removal of solvent by rotary evaporation, the title EPO compounalpha was purified by silica gel chromatography (CombiFlash, 20% ethyl acetate in hexanes to 100% ethyl acetate over 10 minutes.) The appropriate fractions were collected, combined and evaporated to dryness to yield 32 (57.9 mg, 28.0%), ESMS 300.4 (M+H+).

According to the analysis of related databases, 1805-32-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/94003; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 1805-32-9 ,Some common heterocyclic compound, 1805-32-9, molecular formula is C7H6Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step A Preparation 2-[(3,4-dichlorobenzyl)oxy]nitrobenzene A solution of 3,4-dichlorobenzyl alcohol (25.0 g, 141 mmol), 2-fluorobenzaldehyde (14.9 mL, 141 mmol) and potassium carbonate (39.0 g, 282 mmol) in 100 mL of dry DMF was stirred a 60 C. overnight. The DMF was removed in vacuo, and the resulting product was taken up in EtOAc/water. The organic phase was washed with brine, dried (Na2 SO4), filtered, and concentrated in vacuo to provide the titled compound which was used in the next reaction without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1805-32-9, its application will become more common.

Reference:
Patent; Merck & Co., Inc.; US6103723; (2000); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 1805-32-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of the substrate (1 mmol), HMDS (1 mmol) and PC-NPs (20 mg), in acetonitrile (3 mL), was refluxed at 75 C. After completion of the reaction (monitored byTLC using a 1:1 mixture of EtOAc/n-hexane), the mixture was filtered and the residue was washed with acetonitrile (5 mL). Evaporation of the solvent gave almost the pure product(s). Further purification was proceeded by bulb-to-bulb distillation under reduced pressure or recrystallization to afford the pure silyl ether.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1805-32-9, 3,4-Dichlorobenzyl alcohol.

Reference:
Article; Shirini, Farhad; Fallah-Shojaei, Abdollah; Abedini, Masoumeh; Samavi, Laleh; Journal of the Iranian Chemical Society; vol. 13; 9; (2016); p. 1699 – 1712;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 1805-32-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol, molecular formula is C7H6Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(2) To a solution of the compound (440 mg) obtained in Example 131-(1) in tetrahydrofuran (10 ml,), 3,4-dichlorobenzyl alcohol (354 mg) and N,N-diisopropyl ethyl amine (0.680 ml) were added, and the mixed solution was refluxed for eight hours. Furthermore, 3,4-dichlorobenzyl alcohol (354 mg) was added thereto, and the resulting solution was refluxed for eight hours. The solution was returned to room temperature, and ethyl acetate was added thereto. The resulting solution was washed with water, and then washed with a saturated saline solution. The organic layer was dried over anhydrous magnesium sulfate and evaporated under reduced pressure to remove the solvent. The resulting crude product was purified by column chromatography (neutral OH type silica gel, ethyl acetate In-hexane = 0 to 50%) to give methyl (1-{[4-({[(3,4-dichlorobenzyl)oxy]carbonyl}amino)phenyl]carbonyl}isoquinolin-4-yl) acetate (280 mg) as a pale yellow amorphous substance. 1H NMR (600 MHz, CHLOROFORM-d) d ppm 3.73 (s, 3H), 4.11 (s, 2 H), 5.15 (s, 2H), 6.99 (br. s., 1H), 7.20 – 8.25 (m, 11H), 8.51 (s, 1H)

According to the analysis of related databases, 1805-32-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Taisho Pharmaceutical Co., Ltd.; EP2377851; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H6Cl2O

General procedure: The solution of the crude 6D’ and Ph3PHBr (2.16 g, 6.3mmol) in CH3CN was refluxed overnight. Evaporation ofthe reaction mixture yielded 2.25 g of crude compound 7D’ as a white solid in 76% yield (2 steps) and used for the next reaction without further purification

With the rapid development of chemical substances, we look forward to future research findings about 1805-32-9.

Reference:
Article; Kim, Sung-Soo; Fang, Yuanying; Park, Haeil; Bulletin of the Korean Chemical Society; vol. 36; 6; (2015); p. 1676 – 1680;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts