Category: 1805-32-9

Application of 1805-32-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. A new synthetic method of this compound is introduced below.

General procedure: To a solution of 18 (100 mg,0.420 mmol) and [4-(trifluoromethyl)phenyl]methanol (111 mg,0.630 mmol) in THF (10.0 mL), PPh3 (178 mg, 0.68 mmol), a 40%diethyl azodicarbonate toluene solution (309 lL, 0.680 mmol)were added at room temperature, and stirred under N2 atmosphereat 60 C for 4 h. After cooling to room temperature, the solvent wasdistilled off under reduced pressure. The residue was purified bysilica gel column chromatography (hexane/AcOEt = 100:0 to 95:5(v/v)) to obtain 19k as colorless oil (125 mg, 75%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1805-32-9, 3,4-Dichlorobenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Article; Takano, Rieko; Yoshida, Masao; Inoue, Masahiro; Honda, Takeshi; Nakashima, Ryutaro; Matsumoto, Koji; Yano, Tatsuya; Ogata, Tsuneaki; Watanabe, Nobuaki; Hirouchi, Masakazu; Kimura, Takako; Toda, Narihiro; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5546 – 5565;,
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Reference of 1805-32-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. A new synthetic method of this compound is introduced below.

General procedure: All the reactions were carefully carried out at 40C in a 25ml flask. In a typical procedure an amount of catalyst along with H2O2 was used for the oxidation process under mild conditions. The oxidation process was monitored by thin layer chromatography technique.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1805-32-9, 3,4-Dichlorobenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Article; Judy Azar, Amir Reza; Safaei, Elham; Mohebbi, Sajjad; Materials Research Bulletin; vol. 70; (2015); p. 753 – 761;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol, molecular formula is C7H6Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 3,4-Dichlorobenzyl alcohol

General procedure: To a stirring mixture of the substrate (1 mmol) and MMTHClO4(7 mg) in CH3CN (3 mL), HMDS (0.75 mmol)was added at room temperature. After completion of thereaction, indicated by TLC, ethyl acetate: n-hexane (3:7),the mixture was filtered to separate the catalyst. The filtratewas washed with acetonitrile (5 mL). Removal of the solvent under reduced pressure gave almost pure productin good to high yields. Further purification was carriedout by column chromatography on silica gel (eluting withEtOAc:hexane = 1:4), if necessary.

With the rapid development of chemical substances, we look forward to future research findings about 1805-32-9.

Reference:
Article; Mashhadinezhad, Maryam; Shirini, Farhad; Mamaghani, Manouchehr; Journal of Nanoscience and Nanotechnology; vol. 19; 4; (2019); p. 2099 – 2107;,
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Adding a certain compound to certain chemical reactions, such as: 1805-32-9, 3,4-Dichlorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1805-32-9, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

Preparation of Examples 6-18 – 6-22 Preparation of 3,4-dichlorobenzyl 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2- yl)ethylcarbamate (6-22)A solution of carbonyl diimidazole (53 mg, 0.30 mmol) in anhydrous methylene chloride (1 mL) was added slowly to a solution of 3,4-dichlorobenzyl alcohol (49 mg, 0.30 mmol) in anhydrous methylene chloride (1 mL) at 0 C under nitrogen. The mixture was warmed to room temperature after which a suspension of 2- (5,6,7,8-tetrahydro-1 ,8-naphthyridin-2-yl)ethanamine hydrochloride (64 mg, 0.30 mmol) and resin-bound diisopropylethylamine (225 mg, 0.90 mmol) in anhydrous methylene chloride (2 mL) was added. The mixture was stirred for 2 h after which the solids were removed by filtration and the solvents were removed from the filtrate under reduced pressure. The residue was purified by flash column chromatography on silica gel, eluting with methanol/methylene chloride (1 :19), to provide 3,4-dichlorobenzyl 2-(5,6,7,8-tetrahydro-1 ,8- naphthyridin-2-yl)ethylcarbamate (39 mg, 34%) as a white solid: 1H NMR (300 MHz, CDCI3) delta 7.48-7.38 (m, 2H), 7.17 (d, 1H), 7.07 (d, 1H), 6.34 (d, 1H), 5.65 (br s, 1 H), 5.06 (S1 2H), 4.78 (br s, 1 H), 3.57-3.45 (m, 2H), 3.45-3.36 (m, 2H), 2.78-2.65 (m, 4H), 1.97-1.86 (m, 2H) ppm; ESI MS m/z 380 .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1805-32-9, its application will become more common.

Reference:
Patent; SCHERING CORPORATION; SHIPPS, Gerald, W., Jr.; CHENG, Cliff, C.; ACHAB, Abdelghani, Abe; YAO, Zhiping; WHITEHURST, Charles, E.; ZHANG, Mingxuan; YANG, Xianshu; HERR, Robert, Jason; ZYCH, Andrew, John; ROY, Sudipta; YANG, Jinhai; WO2010/57101; (2010); A2;,
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Electric Literature of 1805-32-9 ,Some common heterocyclic compound, 1805-32-9, molecular formula is C7H6Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Dissolved e1 – e3 (1.0 equiv) completely in dry DMF, then added NaH (2.2 equiv) to the reaction slowly at 0 C and the resulting mixture was stirred for 20 minutes, and then corresponding R2(CH2)nOH or g1 – g5 (1.2 equiv) was added and the reaction mixture was stirred for 1 h at room temperature. Then it was quenched by H2O, washed with brine and extracted with ethyl acetate. The combined organic layers were dried over anhydrous Na2SO4 and concentrated under vacuum. The residue was purified by chromatography on a silica gel chromatography (petroleum ether/ ethyl acetate = 8:1 to 4:1) to give corresponding products h1 – h22 (yield 75% – 89%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1805-32-9, its application will become more common.

Reference:
Article; Cheng, Kai; Li, Shiyu; Lv, Xiao; Tian, Yongbin; Kong, Haiyan; Huang, Xufeng; Duan, Yajun; Han, Jihong; Xie, Zhouling; Liao, Chenzhong; Bioorganic and Medicinal Chemistry Letters; vol. 29; 8; (2019); p. 1012 – 1018;,
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Related Products of 1805-32-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The oxidation of alcohols was performed in an autoclave reactor equipped with a magnetic stirrer, thermocouple, automatic temperature controller and a pressure gauge. After the addition of desired amount of reactant, catalyst, water and NaOH, the autoclave was sealed. The atmosphere over the mixture was replaced with O2 for three times. Then the reactor was heated to the desired temperature with stirring. Subsequently, the pressure of O2 was charged to 1.0 MPa and kept constant during the reaction through feeding O2. When the reaction was finished, the reactor was cooled down to the ambient temperature. The reaction mixture was diluted with acetone to dissolve the products. After the catalyst was separated, the filtrate was acidified to pH of 2.0 by hydrochloric acid. The oxidation products were analyzed by gas chromatography equipped with a flame ionization detector. The isolated yield of carboxyl acid was obtained with the following procedure. The solvent of the mixture after acidification was removed through rotary evaporation. The pH of the residual was adjusted to 10.0 with NaOH (2.0 M), and then it was extracted with ethyl acetate for three times. The aqueous layer was acidified to pH 2.0 using HCl (6.0 M) and extracted with ethyl acetate. The organic layer was removed ethyl acetate through rotary evaporation to get the carboxylic acid. The carboxylic acid was dried overnight for calculation of the isolated yield.

According to the analysis of related databases, 1805-32-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhou, Lipeng; Chen, Minzhu; Wang, Youqiang; Su, Yunlai; Yang, Xiaomei; Chen, Chen; Xu, Jie; Applied Catalysis A: General; vol. 475; (2014); p. 347 – 354;,
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Electric Literature of 1805-32-9, Adding some certain compound to certain chemical reactions, such as: 1805-32-9, name is 3,4-Dichlorobenzyl alcohol,molecular formula is C7H6Cl2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1805-32-9.

Under nitrogen, 4-aminobenzenesulfonamide (172 mg, 1 mmol), [Cp * IrCl2] 2 (8 mg, 0.01 mmol,1 mol%), cesium carbonate (65 mg, 0.2 mmol), 3,4-dichlorobenzyl alcohol (212 mg, 1.2 mmol)The alcohol (1.0 mL) was added sequentially to a 25 mL Schlenk reaction flask. The mixture was reacted at 120 C for 12 hoursAfter cooling to room temperature, the solvent was removed under vacuum. And then purified by column chromatography (developing solvent: ethyl acetate / n-hexane)The pure title compound was obtained in a yield of 92%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1805-32-9, 3,4-Dichlorobenzyl alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY; LI, FENG; LU, LEI; MA, JUAN; (16 pag.)CN106146358; (2016); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1805-32-9

Examples 204-206 were prepared according to the method described below: 6′-[(3R)-3-{[tert-Butyl(dimethyl)silyl]oxy}pyrrolidin-1-yl]-2-oxo-2H-1,3′-bipyridin-4-yl 4-bromobenzenesulfonate from Preparation 47 (197 mg, 0.324 mmol), the appropriate benzyl alcohol (0.982 mmol) and potassium hydroxide (55 mg) in DMSO (3 ml) were heated at 130 C. under nitrogen for 1 hour then allowed to stand at r.t. overnight. The reactions were diluted with methanol (3 ml) and passed down a SCX column, washed with methanol and the product eluted with 2M NH3 in methanol, evapourated to dryness. The residue was chromatographed on Biotage 12×150 mm silica column eluting with DCM/MeOH/NH3 98/2/0 to 93/7/1. Solvent removed in vacuo to give the title compound as solids. 204 LC-MS RT = 1.20 min m/z (APCI & ESI) 432 [MH+](2 min run)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1805-32-9, 3,4-Dichlorobenzyl alcohol.

Reference:
Patent; Pfizer Inc; US2008/85884; (2008); A1;,
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Alcohols – Chemistry LibreTexts

Application of 1805-32-9, Adding some certain compound to certain chemical reactions, such as: 1805-32-9, name is 3,4-Dichlorobenzyl alcohol,molecular formula is C7H6Cl2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1805-32-9.

EXAMPLE 8 1-(3,4-Dichlorobenzyloxy)-3-methyl-4-isoquinoline Acetic Acid 1,2-Dihydro-3-methyl-1-oxo-4-isoquinoline acetic acid (770 mg., 3.30 mmol) and phosphorous oxychloride (1.0 ml. 10.7 mmol) were refluxed in 8 ml. ethyl acetate for 16 hr then vacuum evaporated to dryness. The residue was partitioned between water and ethyl acetate. The aqueous phase was washed with ether. The combined organic phases were washed with brine, dried over magnesium sulfate, filtered, and vacuum evaporated to yield a viscous, homogeneous oil, 1-chloro-3-methyl-4-isoquinoline acetic acid; 772 mg. (99%). This oil (623 mg., 2.65 mmol) in 6 ml. dimethylformamide was added to a solution of 3,4-dichlorobenzyl alcohol (2.75 g., 15.5 mmol) and potassium tert-butoxide (600 mg., 534 mmol) in 2 ml. dimethylformamide and the mixture was heated at 115 for 3 hr. After cooling the mixture was poured onto crushed ice and washed with 3*60 ml. ether. The basic aqueous layer was acidified to pH 3 with 1 N hydrochloric acid and extracted 3*100 ml. ether. The organic extract was dried over magnesium sulfate, filtered, and vacuum evaporated to an oily solid; 568 mg. (57%). Trituration of this residue with methanol then hexane and fractional crystallization from chloroform afforded pure title compound: 44 mg. (4%), mp 180-183.

According to the analysis of related databases, 1805-32-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pfizer Inc.; US4283539; (1981); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1805-32-9

4-methyl-benzenesulfonamide (171mg, 1mmol), catalyst A (8.3mg, 0.01mmol, 1.0mol%), cesium carbonate (33mg, 0.1mmol, 0.1equiv.), 3,4- dichlorobenzyl alcohol ( 212mg, 1.2mmol) and water (1ml) were successively added to the reaction flask 25mlSchlenk.After the reaction mixture was reacted at 120 15 hours, cooled to room temperature.Heavy precipitate precipitated, water was removed by filtration, the filter cake was washed with water three times to give the title compound, yield: 92%

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1805-32-9, 3,4-Dichlorobenzyl alcohol.

Reference:
Patent; Nanjing University of Science & Technology; Li, Feng; Qu, panpan; Sun, chunlou; Ma, Juan; (17 pag.)CN104418678; (2016); B;,
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