Category: 179811-63-3

Application of 179811-63-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.179811-63-3, name is 2-Amino-2-(3-chlorophenyl)ethanol, molecular formula is C8H10ClNO, molecular weight is 171.6241, as common compound, the synthetic route is as follows.

To a stirred solution of 1-(5-chloro-2-(phenylamino)pyridin-4-yl)-1H-imidazole-4-carboxylic acid (0.035 g, 0.11 mmol) in NMP (1.5 mL) was added EDC (0.065 g, 0.33 mmol), HO t (0.005 g, 0.033 mmol), triethylamine (0.02 mL, 0.22 mmol), and 2-amino-2-(3-chlorophenyl)ethanol (0.022 g, 0.13 mmol). The reaction mixture was stirred at RT overnight. The mixture was diluted with water (10 mL) and extracted with ethyl acetate (3×15 mL). The combined organic layers were washed with brine (10 mL), dried over sodium sulfate, and evaporated under reduced pressure. The crude residue was purified by preparative TLC using methanol in DCM as eluent to afford 1-(5-chloro-2-(phenylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-imidazole-4-carboxamide as an off-white solid (19 mg, 36% yield). 1HNMR (400 MHz, DMSO-d6): delta 9.44 (s, 1H), 8.41 (s, 1H), 8.38 (d, J=4.0 Hz, 1H), 8.16 (s, 1H), 8.02 (s, 1H), 7.61 (d, J=7.6 Hz, 2H), 7.44 (s, 1H), 7.33-7.30 (m, 2H), 7.29-7.27 (m, 3H), 6.93 (s, 2H), 5.02-5.01 (m, 2H), 3.72 (t, J=5.6 Hz, 2H). LC-MS calcd exact mass 467.09, found m/z 468.1 [M+H]+; HPLC purity 99.88%.

Statistics shows that 179811-63-3 is playing an increasingly important role. we look forward to future research findings about 2-Amino-2-(3-chlorophenyl)ethanol.

Reference:
Patent; Asana Biosciences, LLC; Venkatesan, Aranapakam M.; Thompson, Scott K.; Smith, Roger A.; Reddy, Sanjeeva P.; (166 pag.)US2016/362407; (2016); A1;,
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Electric Literature of 179811-63-3 ,Some common heterocyclic compound, 179811-63-3, molecular formula is C8H10ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound VI (9.63 g, 25.0 mmol), 2-amino-2-(3-chlorophenyl)ethyl-1-ol (VII-2) (4.29 g, 25.0 mmol) and triethylamine (10.4 mL, 74.9mmol) dissolved in methanol (100mL), reflux reaction for about 6h, until TLC (dichloromethane: methanol = 20:1) detection of the reaction of the raw materials was completed, cooled to below 10 C in an ice bath, stirred for 30min, solid precipitation, suction filtration ,A white solid 7.2 g was obtained, yield: 64.9%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 179811-63-3, 2-Amino-2-(3-chlorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; China Pharmaceutical University; Xu Yungen; Ji Dezhong; Zhang Lingzhi; Zhu Qihua; Bai Ying; Wu Yaoyao; (41 pag.)CN109608444; (2019); A;,
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Application of 179811-63-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 179811-63-3, name is 2-Amino-2-(3-chlorophenyl)ethanol, molecular formula is C8H10ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a mixture of 20 (2.60 mmol) and corresponding amine (2.60 mmol) in MeOH (10 mL) was added Et3N (540.00 mul, 3.90 mmol). The mixture was refluxed for 6h. After completion, the mixture was cooled to 0 oC, and stirred for 30 min, the precipitate was filtered to obtain corresponding product. 2.16.1. 2-(1-(3-chlorophenyl)-2-hydroxyethyl)-6-(2-(methylsulfonyl) pyrimidin-4-yl) isoi-ndolin-1-one (21a) Yield 65%. m.p. 166~167 oC. 1H NMR (300 MHz, CDCl3) delta (ppm): 9.01 (d, J = 5.30 Hz, 1H, ArH), 8.49 (s, 1H, ArH), 8.44 (dd, J = 8.00, 1.50 Hz, 1H, ArH), 8.01 (d, J = 5.30 Hz, 1H, ArH), 7.58 (d, J = 8.00 Hz, 1H, ArH), 7.50-7.31 (m, 3H, ArH), 7.28-7.26 (m, 1H, ArH), 5.40 (dd, J = 7.90, 4.40 Hz, 1H, CHCH2OH), 4.63 (d, J = 17.80 Hz, 1H, CH2), 4.43 – 4.32 (m, 2H, HOCH2CH), 4.28 (dd, J = 11.90, 4.40 Hz, 1H, CH2), 3.49 (s, 3H, SO2CH3 ).

According to the analysis of related databases, 179811-63-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ji, Dezhong; Zhang, Lingzhi; Zhu, Qihua; Bai, Ying; Wu, Yaoyao; Xu, Yungen; European Journal of Medicinal Chemistry; vol. 164; (2019); p. 334 – 341;,
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