Category: 17849-38-6

Adding a certain compound to certain chemical reactions, such as: 17849-38-6, 2-Chlorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Chlorobenzyl alcohol, blongs to alcohols-buliding-blocks compound. Quality Control of 2-Chlorobenzyl alcohol

General procedure: A mixture of the substrate (1 mmol), hexamethyldisilazane (0.70 mmol), and/or 3,4-dihydro-2H-pyran (1.4 mmol) and BiPy(SO3H)2(HSO4)2 (10 mg, 1.95 mol%) in CH3CN(3 mL) and/or CH2Cl2 (3 mL) was stirred at room temperature. The progress of thereaction was monitored by TLC (n-hexane: EtOAc; 10:1) and/or GC. After completion ofthe reaction, the mixture was filtered to separate the solid catalyst. Then the solution wasfiltered through a silica gel pad and washed with CH3CN (2 × 3 mL) and/or CH2Cl2 (2 ×3 mL). Evaporation of the solvent gave the desired products in high purity.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,17849-38-6, 2-Chlorobenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Article; Shirini, Farhad; Abedini, Masoumeh; Mahmoodi, Nosratollah; Biglari, Mohammad; Safarpoor Nikoo Langrudi, Mohaddeseh; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 190; 11; (2015); p. 1912 – 1921;,
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Application of 17849-38-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 17849-38-6 as follows.

4-methyl-benzenesulfonamide (171mg, 1mmol), catalyst A (8.3mg, 0.01mmol, 1.0mol%), cesium carbonate (33mg, 0.1mmol, 0.1equiv.), 2- chlorobenzyl alcohol (171mg, 1.2 mmol) and water (1ml) were successively added 25ml Schlenk reaction flask.After the reaction mixture was reacted at 120 15 hours, cooled to room temperature.After the reaction mixture was reacted at 120 15 hours, cooled to room temperature.A large amount of precipitated, water was removed by filtration, the filter cake was washed with water three times to give the title compound, yield: 92%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17849-38-6, its application will become more common.

Reference:
Patent; Nanjing University of Science & Technology; Li, Feng; Qu, panpan; Sun, chunlou; Ma, Juan; (17 pag.)CN104418678; (2016); B;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17849-38-6, name is 2-Chlorobenzyl alcohol, the common compound, a new synthetic route is introduced below. Recommanded Product: 2-Chlorobenzyl alcohol

General procedure: To a mixture of alcohol (1.0 mmol) and KI (1.5 mmol, 0.25 g) in acetonitrile (5 mL), P2O5 (1.5 mmol, 0.23 g) was added and the reaction stirred at room temperature for the time specified in Table 2. After reaction completion (TLC or GC), the reaction mixture was filtered and the residue washed with ethyl acetate (3 × 8 mL). The combined organic layers were washed with an aqueous solution of Na2S2O3 (10%, 10 mL), water (10 mL), and dried over Na2SO4. The solvent was removed under reduced pressure to afford the corresponding product. If necessary, further purification was performed by column chromatography.

The synthetic route of 17849-38-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Khazdooz, Leila; Zarei, Amin; Aghaei, Hamidreza; Azizi, Ghobad; Gheisari, Mohammad Mehdi; Tetrahedron Letters; vol. 57; 2; (2016); p. 168 – 171;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17849-38-6, name is 2-Chlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H7ClO

In the installation of a stirrer, thermometer,In the reaction vessel of the distillation apparatus,3.1 mol of o-chlorobenzyl alcohol (2), 3.9 mol of aniline (3)Mass fraction 65% nitromethane 310ml, cuprous chloride 1.56mol, mixing evenly,The stirring speed was controlled at 160 rpm, the solution temperature was raised to 115 & lt; 0 & gt;Reaction 5h, Raising the solution temperature to 135 & lt; 0 & gt; C,Reaction 3h,The temperature of the solution was raised to 195 C,Reaction 120min,The solution temperature was lowered to 20 & lt; 0 &Adding ammonium nitrate solution 700ml,Mass fraction of 45% sodium bisulfite solution 130ml, 1.7kPa vacuum distillation,Fractions of 130-135 C were collected,Mass fraction of 75% triethylamine washing,In the mass fraction of 95% toluene recrystallization,To obtain the crystal o-chlorobenzonitrile 350.80g, yield 82%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 17849-38-6, 2-Chlorobenzyl alcohol.

Reference:
Patent; Chengdu Chiba Longhua Petroleum Engineering Consulting Co., Ltd; Guan, Genan; (4 pag.)CN105566156; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 17849-38-6, 2-Chlorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Chlorobenzyl alcohol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2-Chlorobenzyl alcohol

a) 100 ml of HBr (48%) were heated to 90 and treated portionwise with 1.43 g (0.01 mol) of 2-chlorobenzyl alcohol. The mixture was stirred for 1/4 hr. and then cooled to room temperature. The mixture was extracted with ethyl acetate and the organic phase was washed with water and saturated sodium chloride solution and dried over sodium sulfate. 1.75g (85%) of 2-chlorobenzyl bromide were obtained as a slightly turbid, colorless oil; b.p. 130/30 mmHg.

The synthetic route of 17849-38-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoffmann-La Roche Inc.; US5753679; (1998); A;,
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Synthetic Route of 17849-38-6 , The common heterocyclic compound, 17849-38-6, name is 2-Chlorobenzyl alcohol, molecular formula is C7H7ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: DBDMH (20 mmol) was added in portion wise to a mixture of 1b (5 mmol) andmethanol (30 ml). The reaction was kept at room temperature. After the mixture wasstirred for 12h, the methanol was vacuum evaporated. The residue was dissolved byMTBE (30 ml), washed with water (330 ml).The organic extracts was dried byanhydrous MgSO4, filtered, and concentrated under reduce pressure. The residue waspurified by column chromatography (silica gel: petroleum ether/ethyl acetate, 30:1) toafford the product as light yellow solid ( 92% yield).

The synthetic route of 17849-38-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Zhongzhou; Zhu, Wei; Bao, Jinlong; Zou, Xinzhuo; Synthetic Communications; vol. 44; 8; (2014); p. 1155 – 1164;,
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