Category: 178312-48-6

Related Products of 178312-48-6 ,Some common heterocyclic compound, 178312-48-6, molecular formula is C7H12F2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The above (4, 4-difluorocyclohexyl) methanol was dissolved in 5 ml of pyridine. Thereto 2.2 g of p- toluenesulfonyl chloride was added at 0C and the mixture was stirred at room temperature overnight. Thereafter, the reaction mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, washed successively with water, dilute hydrochloric acid and aqueous saturated sodium chloride, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 3.1 g of 4, 4- difluorocyclohexylmethyl p-toluenesulfonate. 4, 4-Difluorocyclohexylmethyl p-toluenesulfonate: lH-NMR (CDC13, TMS) 5 (ppm): 1.18-1. 37 (2H, m), 1.56-1. 86 (5H, m), 2.00-2. 17 (2H, br), 2.46 (3H, s), 3. 86 (2H, d), 7. 35 (2H, d), 7.78 (2H, d).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 178312-48-6, (4,4-Difluorocyclohexyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2005/63694; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 178312-48-6, name is (4,4-Difluorocyclohexyl)methanol, the common compound, a new synthetic route is introduced below. Recommanded Product: (4,4-Difluorocyclohexyl)methanol

To a solution of the crude product of the previous step (465 mg, 0.31 mmol) and triethylenediamine (0.346 mg, 0.31 mmol) cooled to 0 C. in dichloromethane (20 mL) was added a p-toluenesulfonylchloride (0.589 g, 0.31 mmol) in dichloromethane (5 mL). The reaction mixture was stirred overnight and then washed with 0.5 N HCl (20 mL). The organic layer was collected, dried over anhydrous sodium sulfate, filtered, and concentrated. The crude product was purified by flash column chromatography to give the title compound as a white solid (748 mg).

The synthetic route of 178312-48-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Theravance, Inc.; US2009/62334; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts