Category: 17773-10-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17773-10-3, name is Choline Iodide. A new synthetic method of this compound is introduced below., Safety of Choline Iodide

Preparation of Tetraalkylammonium Hydroxides; The above TAA halides were converted to the equivalent hydroxide using the anion exchange resin, Dowex 550. The general procedure is described in detail for the exchange of choline iodide to choline hydroxide. The resin (30 g) was activated using NaOH before being thoroughly washed with distilled water. To this was added [(CH3)3N(CH2CH2OH)]I (1.99 W 8 mmol) in distilled water (50 ml). This was then agitated on a mixing plate for 24 hours. The resin was removed by filtration and further washed with distilled water (4×15 ml). The filtrate and washings were reduced on a rotary evaporator to a volume of 8 ml. The filtrate was shown to contain no halide using the silver nitrate test. An aliquot of the solution (1 ml) was diluted with water (9 ml) and titrated with HCl (0.1M) to establish the hydroxide content as 1.0M.Calculated yield=0.96 g (99%) (1M solution)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 17773-10-3, Choline Iodide.

Reference:
Patent; PILKINGTON GROUP LIMITED; US2012/263903; (2012); A1;,
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Application of 17773-10-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17773-10-3, name is Choline Iodide. This compound has unique chemical properties. The synthetic route is as follows.

CORM-338; [Me3NCH2CH2OH][Mn(CO)4I2]; 450 mg (1.40 mmol) of [Mn(CO)5I] and 301 mg (1.30 mmol) of choline iodide were stirred in 15 ml of methanol at 55 C. for 36 h. (The IR Spectrum recorded after 2 h showed a significant amount of starting material remained).Following this, the solvent was removed on a rotary evaporator to give a yellow/brown ?oily? solid. This residue was dissolved in DCM, filtered, and then diethyl ether added. This precipitated out a white solid (presumably unreacted choline iodide) which was filtered off. Solvent was then removed on a rotary evaporator and the residue again dissolved in DCM. A little hexane was then added. However, this resulted in the product separating as an oil. Hence all the solvent was removed on a rotary evaporator and the resulting semi-solid residue washed twice with diethyl ether. This produced a solid product that was dried under vacuum.405 mg (0.771 mmol) of an orange/brown solid was obtained. Mr=524.96.Yield was 59%.1H NMR (CD2Cl2): delta(ppm) 3.11 (br, OH 1H), 3.35 (br, CH3 9H), 3.68 (br, CH2 2H), 4.22 (br, CH2 2H)13O NMR (CD2Cl2): delta(ppm) 55.29 (t {J=3.9 Hz}, CH3), 56.35 (CH2), 68.16 (t {J=2.8 Hz}, CH2), 213.26 (CO), 221.91 (CO)17O NMR (CD2Cl2): delta(ppm) 377.3 (CO), 379.4 (CO)55Mn NMR (CD2Cl2): delta(ppm) -863 line width 6650 HzIR (CH2Cl2) nu(cm-1): 2077 (s), 2002 (vs), 1984 (s), 1942 (s)Mass Spec (m/z): 421 (MO), 393 (M–CO), 365 (M–2CO), 337 (M–3CO), 309 (M–4CO)Elemental: MnC9H14NO5I2 found (calc) C: 20.62 (20.59), H: 2.55 (2.69), N: 2.57 (2.67), I: 48.61 (48.35); CORM-369 (Choline][Mn(CO)4I2] [3]450 mg (1.40 mmol) of Mn(CO)5I and 301 mg (01.30 mmol) of choline iodide were stirred in 15 ml of methanol at 55 C. for 36 hrs. (IR recorded after 2 hrs showed a significant amount of starting material remaining).Following this, the solvent was removed on rotary evaporator to give a yellow/brown ?oily? solid. This residue was dissolved in DCM, filtered, and then ether added. This crashed out a white solid (presumably unreacted choline iodide) which was filtered off. Solvent was then removed on rotary evaporator and the residue again dissolved in DCM. A little hexane was then added. However, this resulted in the product crashing out as an oil. Hence all the solvent was removed on rotary evaporator and the resulting semi-solid residue washed twice with ether. This produced a solid product that was dried under vacuum.405 mg of an orange/brown solid was obtained. Yield was 59.3%.1H NMR (CD2Cl2): delta(ppm) 3.35 (br, NMe3), 3.69 (br, CH2), 4.18 (br, CH2)13C NMR (CD2Cl2): delta(ppm) 54.0 (NMe3), 56.6 (CH2), 68.5 (CH2), 211.6 (CO), 219.8 (CO),IR (CH2Cl2) nu(cm-1): 2092 (w), 2015 (vs), 1989 (s), 1943 (s)Mass Spec (m/z): 215 (M–4CO) (1:2:1 ratio of peaks observed, i.e. 79Br/81Br).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17773-10-3, Choline Iodide.

Reference:
Patent; Motterlini, Roberto Angelo; Mann, Brian Ernest; Scapens, David Alistair; US2010/105770; (2010); A1;,
Alcohol – Wikipedia,
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Application of 17773-10-3 ,Some common heterocyclic compound, 17773-10-3, molecular formula is C5H14INO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate 39 (150 mg, 0.15 mmol) was dissolved in DCM (4 ml) and hydroxyethyltrimethyl-ammonium iodide (173 mg, 0.75 mmol), EDC (86 mg, 0.45 mmol) and DMAP (55 mg, 0.45 mmol) were added. The mixture was stirred at RT for 7 h and water (4 ml) was added. The aqueous layer was separated and evaporated. Purification was achieved using HPLC system 3.Yield: 35 mg (16%)LC-MS (Method 1): Rt 6.78 min, m/z 585.80 [M2+]/2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17773-10-3, Choline Iodide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARGENTA DISCOVERY LTD; WO2006/82412; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts