Category: 1777-82-8

Sulfuryl Fluoride Promoted Thiocyanation of Alcohols: A Practical Method for Preparing Thiocyanates was written by Zhang, Guofu;Xuan, Lidi;Zhao, Yiyong;Ding, Chengrong. And the article was included in Synlett in 2020.Safety of (2,4-Dichlorophenyl)methanol This article mentions the following:

A novel SO₂F₂-promoted thiocyanation method for the one-step synthesis of thiocyanates RCH₂SCN [R = Ph, 2-pyridyl, CH₂(CH₂)₅CH₃, etc.] through C-O bond cleavage of alcs. RCH₂OH with ammonium thiocyanate as the thiocyanating agent was developed. The method avoided the use of addnl. catalyst and a variety of (hetero)arene, alkene and aliphatic alcs. reacted with high efficiency in Et acetate under mild conditions to afford the corresponding thiocyanates RCH₂SCN in excellent to quant. yields with broad functional-group compatibility. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Safety of (2,4-Dichlorophenyl)methanol).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Safety of (2,4-Dichlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iron(III) Amine Bis(phenolate) Complex Immobilized on Silica-Coated Magnetic Nanoparticles: A Highly Efficient Catalyst for the Oxidation of Alcohols and Sulfides was written by Karimpour, Touraj;Safaei, Elham;Karimi, Babak;Lee, Yong-Ill. And the article was included in ChemCatChem in 2018.Synthetic Route of C7H6Cl2O This article mentions the following:

A bis(dihydroxybenzyl)glycinamide iron complex bound to silica- and magnetite nanoparticles was prepared as a magnetically recoverable and supported catalyst for green and chemoselective oxidations of primary and secondary alcs. to carboxylic acids and ketones, resp. and of sulfides to sulfoxides. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Synthetic Route of C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Suspect screening based on market data of polar halogenated micropollutants in river water affected by wastewater was written by Menger, Frank;Ahrens, Lutz;Wiberg, Karin;Gago-Ferrero, Pablo. And the article was included in Journal of Hazardous Materials in 2021.Application of 1777-82-8 This article mentions the following:

Wastewater treatment plants (WWTPs) are known point sources of contaminants of emerging concern (CECs) to the aquatic environment, but current knowledge is mostly limited to well-known chem. structures. In this study, we sought to identify unknown CECs polluting the aquatic environment through a novel suspect screening approach for organohalogens, i.e. organic halogenated mols. often toxic and resistant to transformation and characterised as persistent organic pollutants (POPs). Surface water samples were collected with passive samplers in the Fyris River catchment (Uppsala, Sweden), analyzed using liquid chromatog. high-resolution mass spectrometry (LC-HRMS) and screened for organohalogens using a suspect screening approach based on market data obtained from a regulatory authority. Thirteen suspects from very different application areas were confirmed or tentatively identified with high confidence, including seven previously unknown structures (diflufenican, chlorzoxazone, 3-(3,4-dichlorophenyl)-1,1-dimethylurea, 2,4-disulfamyl-5-trifluoromethylaniline, 5-amino-2-chlorotoluene-4-sulfonic acid, perfluoropentane-1-sufonic acid, (2-chlorophenyl)(hydroxy)methanesulfonic acid). Spatiotemporal occurrence patterns were detected, which helped to understand the usage pattern of the chems. and pinpoint potential pollution sources, e.g. specific WWTPs in the catchment. Several of the newly identified structures had virtually no information publicly available and were detected years after their last registered use, which highlights the knowledge gaps and concerns about POPs. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Application of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of 1,4-Benzodiazepine-2,5-dione (BZD) Derivatives as Dual Nucleotide Binding Oligomerization Domain Containing 1/2 (NOD1/NOD2) Antagonists Sensitizing Paclitaxel (PTX) To Suppress Lewis Lung Carcinoma (LLC) Growth in Vivo was written by Wang, Suhua;Yang, Jingshu;Li, Xueyuan;Liu, Zijie;Wu, Youzhen;Si, Guangxu;Tao, Yiran;Zhao, Nan;Hu, Xiao;Ma, Yao;Liu, Gang. And the article was included in Journal of Medicinal Chemistry in 2017.Electric Literature of C7H6Cl2O This article mentions the following:

Nucleotide-binding oligomerization domain-like receptors (NLRs) are intracellular sensors of pathogen-associated mol. patterns (PAMPs) and damage-associated mol. patterns (DAMPs). Previously, we reported nucleotide-binding oligomerization domain-containing protein 1 (NOD1) antagonists (11, 12) and a NOD2 antagonist (9) that sensitized docetaxel (DTX) or paclitaxel (PTX) treatment for breast or lung cancer. In this article, we describe for the first time a 1,4-benzodiazepine-2,5-dione (BZD) derivative (26bh) that acts as a dual NOD1/NOD2 antagonist and inhibits both nuclear factor κB (NF-κB) and mitogen-activated protein kinase (MAPK) inflammatory signaling, thereby sensitizing PTX to suppress Lewis lung carcinoma (LLC) growth. After investigation of the compound’s cytotoxicity, a systematic structure-activity relationship (SAR) was completed and revealed several key factors that were necessary to maintain antagonistic ability. This study establishes the possibility for using adjuvant treatment to combat cancer by antagonizing both NOD1 and NOD2 signaling. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Electric Literature of C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Eco-friendly mechanochemical preparation of Ag2O-MnO2/graphene oxide nanocomposite: an efficient and reusable yst for the base-free, aerial oxidation of alcohols was written by Adil, Syed Farooq;Assal, Mohamed E.;Khan, Mujeeb;Shaik, Mohammed Rafi;Kuniyil, Mufsir;Sekou, Doumbia;Dewidar, Ahmed Z.;Al-Warthan, Abdulrahman;Siddiqui, Mohammed Rafiq H.. And the article was included in Catalysts in 2020.Reference of 1777-82-8 This article mentions the following:

Recently, the development of eco-friendly mechanochem. approaches for the preparation of novel ysts with enhanced activity and selectivity has gained considerable attention. Herein, we developed a rapid and solvent-less mechanochem. method for the preparation of mixed metal oxide (Ag₂O-MnO₂) decorated graphene oxide (GRO)-based nanocomposites (Ag₂O-MnO₂/(X weight%)GRO), as the Ag₂O-MnO₂/(X weight%)GRO nanocomposite was fabricated by the phys. grinding of freshly prepared GRO and pre-annealed (300°C) mixed metal oxide nanoparticles (NPs) (Ag2O-MnO2) using an eco-friendly milling procedure. The as-prepared nanoysts were characterized by using various techniques. Furthermore, the nanocomposites were applied as a heterogeneous yst for the oxidation of alc. by employing gaseous O₂ as an eco-friendly oxidant under base-free conditions. The mechanochem. obtained GRO-based composite exhibited noticeable enhancement in the surface area and ytic performance compared to the pristine Ag₂O-MnO₂. The results revealed that (1%)Ag₂O-MnO₂/(5 weight%)GRO yst exhibited higher specific performance (13.3 mmol.g^-1.h^-1) with a 100% conversion of benzyl alc. (BnOH) and >99% selectivity towards benzaldehyde (BnH) within 30 min. The enhancement of the activity and selectivity of GRO-based nanoyst was attributed to the presence of various oxygen-containing functional groups, a large number of defects, and a high sp. surface area of GRO. In addition, the as-prepared nanoyst also demonstrated excellent ytic activity towards the conversion of a variety of other alcs. to resp. carbonyls under optimal conditions. Besides, the yst ((1%)Ag₂O-MnO₂/(5 weight%)GRO) could be efficiently recycled six times with no noticeable loss in its performance and selectivity. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Reference of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Reference of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, spectral characterization, SC-XRD, HSA, DFT and catalytic activity of a dioxidomolybdenum complex with aminosalicyl-hydrazone Schiff base ligand: An experimental and theoretical approach was written by Kargar, Hadi;Fallah-Mehrjardi, Mehdi;Behjatmanesh-Ardakani, Reza;Munawar, Khurram Shahzad;Ashfaq, Muhammad;Tahir, Muhammad Nawaz. And the article was included in Polyhedron in 2021.Computed Properties of C7H6Cl2O This article mentions the following:

A new dioxidomolybdenum(VI) complex has been successfully prepared by the reaction of an ONO donor Schiff base, derived by condensing 4-amino-2-hydroxybenzohydrazide and 3-methoxysalicylaldehyde, with MoO₂(acac)₂. The structures of synthesized products were explored spectroscopically through FT-IR, ¹H & ¹³C NMR and by elemental composition (CHN) through combustion anal. The structural investigations of the dioxidomolybdenum(VI) complex were accomplished by taking its diffraction data through X-ray crystallog. The tridentate Schiff base ligand is bonded to the central metal through its deprotonated enolic and phenolic oxygen atoms and by the nitrogen of the azomethine group. The interpretation of the data obtained through diffraction anal. validates the distorted octahedral geometry of the prepared metal complex. QTAIM, MEP and NCI calculations and Hirshfeld surface anal. were performed to investigate the nature and types of non-covalent linkages present among the sample mols. The theor. calculations, performed by DFT using the B3LYP/Def2-TZVP level of theory, direct that the intended outcomes are in compliance with the actual consequences. Furthermore, the catalytic potential of the molybdenum complex was explored for the selective oxidation of benzylic alcs. to the desirable aryl aldehydes at room temperature in the presence of 70% aqueous tert-Bu hydroperoxide (TBHP) under solvent-free conditions. The main advantage of the present catalytic work is the accomplishment of reaction in a short period of time, high percentage yield and easy work-out procedure. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Computed Properties of C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synergistic catalysis within core-shell Fe₃O₄@SiO₂ functionalized with triethylene glycol (TEG)-imidazolium ionic liquid and tetramethylpiperidine N-oxyl (TEMPO) boosting selective aerobic oxidation of alcohols was written by Karimi, Babak;Ghaffari, Bahareh;Vali, Hojatollah. And the article was included in Journal of Colloid and Interface Science in 2021.Formula: C7H6Cl2O This article mentions the following:

It is expected that incorporation of 2, 2, 6, 6-tetra-Me piperidine-N-oxyl radical (TEMPO) and an imidazolium bromide bearing hydrophilic triethylene glycol (TEG) groups on Fe₃O₄@SiO₂ core-shell may not only result in a novel highly water-dispersible/magnetically separable multi-functional catalyst system for metal-free aerobic oxidation of alcs., which operates through a synergistic relay pathway, but it could potentially provide a strong platform for simultaneous separation and recycling of all components. The catalyst was prepared by anchoring TEMPO moieties onto a magnetic core-shell Fe₃O₄@SiO₂ functionalized with an ionic liquid bearing TEG groups. The materials was characterized using transmission electron microscopy, Fourier transform IR spectroscopy, nitrogen adsorption-desorption isotherms, thermal gravimetric anal., and elemental anal. The performance of the catalyst was evaluated and quant. measured in the aerobic oxidation of alcs. in water. The catalyst exhibited excellent and stable colloidal dispersion in water and high performance in the aerobic oxidation of various types of alcs. under metal- and halogen-free reaction conditions. As hypothesized, strong synergistic effect between functionalized components was seen in the described reaction. The catalyst displayed excellent dual-adjustable-selectivity in the oxidation of primary alcs. to either the corresponding aldehydes or carboxylic acids by tuning the reaction solvent and/or reaction time and excellent recycling behavior through a “double-separation-strategy”. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Formula: C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ruthenium Catalyzed N-Alkylation of Cyclic Amines with Primary Alcohols was written by Savela, Risto;Vogt, Dieter;Leino, Reko. And the article was included in European Journal of Organic Chemistry in 2020.SDS of cas: 1777-82-8 This article mentions the following:

A robust alc. amination protocol using common saturated amines and primary alcs. as starting materials is described. The reactions are catalyzed by combination of dichloro(p-cymene)ruthenium(II) dimer precatalyst with triphenylphosphine ligand, with the excess alc. substrate or toluene functioning as the solvent. The catalyst and ligand residues can be precipitated from the reaction media by addition of hexane or cold di-Et ether, followed by precipitation and isolation of the product as a hydrochloride salt. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8SDS of cas: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Water-Triggered Metal-Free Synthesis of Pyranopyrazoles via One-Pot Oxidation/Michael Addition/Cyclization/Dehydration Sequence. was written by Dandia, Anshu;Bansal, Sarika;Sharma, Ruchi;Parewa, Vijay. And the article was included in ChemistrySelect in 2018.HPLC of Formula: 1777-82-8 This article mentions the following:

An ”all water” strategy for the catalyst free chemo-selective synthesis of pyranopyrazoles via the reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one with benzyl alcs. was developed. Water actuated the reaction via ‘electrophile-nucleophile dual activation’ of the reactants through the concerted hydrogen bonding network and impel the reactants for C-C bond formation. Reaction proceeded by metal and catalyst free oxidation-Michael addition-cyclization-dehydration sequence. This method gave pyrano[[2, 3-c:6,5-c’]dipyrazol]-2-ones selectivity over other possible products. Furthermore, this method was also applied on the reaction of the benzyl alcs. and dimedone to give arylmethylene[bis(5,5-dimethyl-3-hydroxy-2-cyclohexene-1-ones)] in good to excellent yields. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8HPLC of Formula: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Halobenzyl alcohols as structurally simple organogelators was written by Prathap, Annamalai;Ravi, Arthi;Pathan, Javed R.;Sureshan, Kana M.. And the article was included in CrystEngComm in 2019.Recommanded Product: 1777-82-8 This article mentions the following:

We report 11 simple halobenzyl alcs., each comprising of only 16 atoms, as organogelators for aliphatic hydrocarbon solvents. Comparison of PXRD profiles of wet gels and xerogels with the simulated profiles from the single crystal XRD data confirmed that the mol. packing in gels and crystals are identical. Therefore single crystal X-ray structures were analyzed to understand the mol. level interactions involved in the self-assembly in gel state. Each of these compounds undergoes a faster linear assembly along the crystallog. direction associated with the OH···O hydrogen bond and a supplementary non-covalent interaction (NCI). In directions perpendicular to the direction of OH···O Hydrogen bonding, mols. associate through various relatively weaker NCIs. Notably, halogen bonds, X···X, C-H···X interactions play major role in the lateral growth. In the case of gels, the linear growth is faster than lateral growth leading to the formation of long fibers, which entangles to a 3D fibrous network. This study reveals that halogen atoms in halobenzyl alcs. impart mol. features that contribute to their self-assembly in solution and hence in gelation. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Recommanded Product: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts