Synthetic Route of 1737-26-4 ,Some common heterocyclic compound, 1737-26-4, molecular formula is C9H9F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Under nitrogen atmosphere, to a 15-mL Pyrex glass screw-cap tube were added 1-phenylethanol (1a: 0.613 g, 5 mmol), benzyl alcohol (2a: 0.543 g, 5 mmol), K3PO4 (531 mg, 2.5 mmol), and Pt-Sn/gamma-Al2O3 (catalyst III: 147 mg, 0.075 mol % Pt). The resultant mixture was stirred in the sealed tube at 155 C for 48 h. After cooled to ambient temperature, the catalyst and base were removed by centrifugation and washed with Et2O (2×5 mL). The combined supernatant was condensed under reduced pressure and subject to purification by silica gel column chromatography (eluent: petroleum ether (60-90 C)/EtOAc = 20:1, v/v), affording product 3a as a white solid (1.018 g, 96%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1737-26-4, 1-[4-(Trifluoromethyl)phenyl]ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Wu, Kaikai; He, Wei; Sun, Chenglin; Yu, Zhengkun; Tetrahedron Letters; vol. 57; 36; (2016); p. 4017 – 4020;,
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