Category: 17236-59-8

Sheina, Elena E. published the artcileToward poly(3- and 3,4-alkoxythiophenes), Quality Control of 17236-59-8, the publication is Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) (2003), 44(1), 843-844, database is CAplus.

Regioregular head-to-tail 3-alkoxy-substituted polythiophenes (PTs) (with R=C₆H₁₃O- and CH₃OC₂H₄OC₂H₄O-) and poly(2,5-(3-functionalized-3,4-ethylenedioxy)bithiophene) with dodecyl and diethyleneglycol Me Et as hydrophobic and hydrophilic substituents, resp., were polymerized via a Grignard Methathesis Method (GRIM). Mol. weights were characterized by gel permeation chromatog. (GPC) and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectroscopy, where the latter was used to obtain the end group composition UV-vis NIR spectroscopic studies showed that due to the presence of the electron donating oxygen atom, directly attached to the ring, the 3-alkoxy-substituted PTs possess a lower band gap than their alkyl analogs. The polymers self-oxidized in air and conductivity measurements revealed that further doping with I2 increases conductivity and prolongs the stability of the doped state. Poly(3-alkoxythiophenes) remain in the doped state for as long as three weeks.

Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C8H15ClN2, Quality Control of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hayashi, Ryuji published the artcileSynthesis and evaluation of novel heterocyclic MMP inhibitors, Synthetic Route of 17236-59-8, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(24), 6864-6870, database is CAplus and MEDLINE.

A variety of novel heterocyclic compounds, e.g., I, were synthesized and evaluated for MMP inhibition. Broad spectrum inhibition of MMPs 1, 2, 9, and 12 was found with pyridinone-based compounds while N-heterocyclic triazoles and tetrazoles were largely ineffective. A highly selective tetrazole inhibitor for MMP-2 was discovered.

Bioorganic & Medicinal Chemistry Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Synthetic Route of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Baell, Jonathan B. published the artcileNew Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays, Related Products of alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2010), 53(7), 2719-2740, database is CAplus and MEDLINE.

This report describes a number of substructural features which can help to identify compounds that appear as frequent hitters (promiscuous compounds) in many biochem. high throughput screens. The compounds identified by such substructural features are not recognized by filters commonly used to identify reactive compounds Even though these substructural features were identified using only one assay detection technol., such compounds have been reported to be active from many different assays. In fact, these compounds are increasingly prevalent in the literature as potential starting points for further exploration, whereas they may not be.

Journal of Medicinal Chemistry published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Capon, Brian published the artcileSome studies on the tautomerism of heterocyclic and homocyclic compounds, Quality Control of 17236-59-8, the publication is Pure and Applied Chemistry (1987), 59(12), 1577-84, database is CAplus.

The following hydroxy derivatives of heterocyclic compounds have been generated in solution and characterized by ¹H-NMR spectroscopy: 3-hydroxyfuran, 3-hydroxythiophene, 3-hydroxypyrrole, 3-hydroxy-1-methylpyrrole, 3-hydroxybenzofuran, 3-hydroxybenzothiophene, 3-hydroxyindole, 3-hydroxy-1-methylindole, 2-hydroxythiophene, 2-hydroxybenzothiophene, 2,5-dihydroxythiophene. The rate and equilibrium constants for their ketonization have been measured and are discussed. The following hydroxy derivatives of homocyclic compounds were also generated, characterized and investigated: 1-hydroxyindene, 2-hydroxyindene, 1-hydroxycyclohepta-1,3,5-triene, 3-hydroxycyclohepta-1,3,5-triene, hydroxycyclooctatetraene, and 3-hydroxycycloocta-1,3,5-triene. The mechanism of hydrolysis of heterocyclic Me ethers derived from furan, thiophene, 1-methylpyrrole and their benzo-derivatives has been investigated and a change in rate limiting step from C-protonation to nucleophilic attack by water on the intermediate cation detected.

Pure and Applied Chemistry published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Quality Control of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gogoi, Nibedita published the artcileGrafting of Ru(III) complex onto nanosilica and its implication as heterogeneous catalyst for aerobic oxidative hydroxylation of arylboronic acids, Application In Synthesis of 17236-59-8, the publication is Tetrahedron Letters (2016), 57(36), 4050-4052, database is CAplus.

An ecofriendly and highly efficient protocol for aerobic oxidative hydroxylation of aryl and heteroaryl boronic acids catalyzed by Ru(III) amidine complex immobilized on nanosilica, derived from rice husk, has been developed. The main significance of this protocol is the base free and aerobic reaction condition at room temperature, short reaction time, aqueous reaction medium, and excellent yield of the product. This heterogeneous catalyst is reusable up to sixth cycle without loss in activity.

Tetrahedron Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Application In Synthesis of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dindarloo Inaloo, Iman published the artcileNickel-Catalyzed Synthesis of N-(Hetero)aryl Carbamates from Cyanate Salts and Phenols Activated with Cyanuric Chloride, Application of Thiophen-3-ol, the publication is ChemCatChem (2020), 12(21), 5486-5491, database is CAplus.

A simple and efficient domino reaction has been designed and employed for the one-pot synthesis of N-(hetero)aryl carbamates ArNHC(O)OR (Ar = Ph, thiophen-2-yl, pyridin-3-yl, etc.; R = Pr, cyclohexyl, allyl, etc.) through the reaction between alcs. ROH and in-situ produced (hetero)aryl isocyanates in the presence of a nickel catalyst. The phenolic C-O bond was activated via the reaction of phenol with cyanuric chloride (2,4,6-trichloro-1,3,5-triazine (TCT)) as an inexpensive and readily available reagent. This strategy provides practical access to N-(hetero)aryl carbamates in good yields with high functional groups compatibility.

ChemCatChem published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Application of Thiophen-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Pipeng published the artcileResonance energies and tautomerism of substituted aromatic heterocycles and their benzo derivatives, COA of Formula: C4H4OS, the publication is Youji Huaxue (1991), 11(6), 620-3, database is CAplus.

The recently developed quantified resonance theory (QRT) has been applied to substituted aromatic five- and six-membered heterocycles and their benzo derivatives The calculated resonance energy differences ΔRE between tautomeric forms agree with those estimated from tautomeric equilibrium data for the 2- and 4-pyridone, 2-quinolone and 1-isoquinolone series. For tautomerism of extensive heteroaromatic compounds in solution, the ΔRE and the differences in heats of atomization ΔΔH₃ calculated by QRT can be used to rationalize and predict the predominant tautomer and the shifting trend in the equilibrium for a series of similar compounds

Youji Huaxue published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C22H12F6O6S2, COA of Formula: C4H4OS.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Marques, Michael A. published the artcileToward an understanding of the chemical etiology for DNA minor-groove recognition by polyamides, Safety of Thiophen-3-ol, the publication is Helvetica Chimica Acta (2002), 85(12), 4485-4517, database is CAplus.

Crescent-shaped polyamides composed of aromatic amino acids, i.e., 1-methyl-1H-imidazole Im, 1-methyl-1H-pyrrole Py, and 3-hydroxy-1H-pyrrole Hp, bind in the minor groove of DNA as 2:1 and 1:1 ligand/DNA complexes. DNA-Sequence specificity can be attributed to shape-selective recognition and the unique corners or pairs of corners presented by each heterocycle(s) to the edges of the base pairs on the floor of the minor groove. Here we examine the relationship between heterocycle structure and DNA-sequence specificity for a family of five-membered aromatic amino acids. By means of quant. DNase-I footprinting, the recognition behavior of polyamides containing eight different aromatic amino acids, i.e., 1-methyl-1H-pyrazole Pz, 1H-pyrrole Nh, 5-methylthiazole Nt, 4-methylthiazole Th, 3-methylthiophene Tn, thiophene Tp, 3-hydroxythiophene Ht, and furan Fr, were compared with the polyamides containing the parent-ring amino acids Py, Im, and Hp for their ability to discriminate between the four Watson-Crick base pairs in the DNA minor groove. Anal. of the data and mol. modeling showed that the geometry inherent to each heterocycle plays a significant role in the ability of polyamides to differentiate between DNA sequences. Binding appears sensitive to changes in curvature complementarity between the polyamide and DNA. The Tn/Py pair affords a modest 3-fold discrimination of T · A vs. A · T and suggests that an S-atom in the thiophene ring prefers to lie opposite T not A.

Helvetica Chimica Acta published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Safety of Thiophen-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gong, Weitao published the artcileβ-Diketone boron difluoride dye-functionalized conjugated microporous polymers for efficient aerobic oxidative photocatalysis, Category: alcohols-buliding-blocks, the publication is Catalysis Science & Technology (2021), 11(11), 3905-3913, database is CAplus.

Incorporation of organic chromophores into conjugated micro/mesoporous polymers (CMPs) provides a promising avenue for developing recyclable heterogeneous photocatalysts by overcoming tedious separation and low reusability of homogeneous organic dye-based photocatalysts. However, the design principle and the underlying structure-property relationship for fabricating and selecting various organic dye-embedded CMPs for efficient photocatalysis have not been well-constructed so far. In this study, we described the rational fabrication of two new CMPs via the one-step Sonogashira coupling using β-diketone boron difluoride dye as the key linker and commonly used building blocks (triphenylamine/triphenylbenzene) as the cores. The resulting boron-dye containing CMPs were efficiently employed as the metal-free photocatalysts in two typical aerobic oxidative organic transformations including coupling of benzylamine and oxidation of aryl boronic acids to corresponding aryl phenols, which have never been explored with other boron-dye-embedded CMPs. They exhibited superior photocatalytic performance compared to their boron-free counterparts due to their wide visible-light absorption, narrow optical bandgaps, and extended π-conjugation due to boron-complexation. The present study establishes β-diketone boron difluoride dyes as efficient building blocks for fabricating new CMP-based photocatalysts.

Catalysis Science & Technology published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pozo, Iago published the artcileToward 2-Thiophyne: Ketocarbene versus Hetaryne Intermediates from 2-(Trimethylsilyl)thiophen-3-yl Triflate, Synthetic Route of 17236-59-8, the publication is Organic Letters (2021), 23(19), 7376-7380, database is CAplus and MEDLINE.

The reaction of 2-(trimethylsilyl)thiophen-3-yl triflate with CsF in the presence of 2,3,4,5-tetraphenylcyclopentadienone affords 4,5,6,7-tetraphenylbenzo[b]thiophene, as it would be expected from the hypothesized generation and trapping of 2-thiophyne. However, a detailed exptl. and computational study discards the intermediacy of this elusive 5-membered hetaryne. Instead, a complex mechanism involving the generation of an intermediate ketocarbene, which adds to the cyclopentadienone to give an isolable tricyclic intermediate, followed by thermal rearrangements, is proposed.

Organic Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Synthetic Route of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts