Adding a certain compound to certain chemical reactions, such as: 171623-29-3, (4-Cyclopentylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C12H16O, blongs to alcohols-buliding-blocks compound. COA of Formula: C12H16O
General procedure: Under nitrogen atmosphere, to a stirred mixture of thecorresponding alcohol 11b-am (1.0 eq.) in dry CH2Cl2 (5.0 mL), DMAP (0.1 eq.), and 2-DPC (1.2 eq.)were added. The reaction mixture was stirred at room temperature for 16 h, then diluted with CH2Cl2(20 mL) and sequentially washed with sat. NH4Cl solution (25 mL), sat. NaHCO3 solution (3 x 25 mL)and brine (25 mL). The organic layer was dried over Na2SO4, filtered and concentrated to dryness atlow pressure, as a mixture of alkyl-2-pyridyl carbonate 12b-am and alkyl-2-oxopyridine-1-carboxylate13b-am. The mixture of isomers was not separated and used in the next step without any furtherpurification.
The synthetic route of 171623-29-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Nuzzi, Andrea; Fiasella, Annalisa; Ortega, Jose Antonio; Pagliuca, Chiara; Ponzano, Stefano; Pizzirani, Daniela; Bertozzi, Sine Mandrup; Ottonello, Giuliana; Tarozzo, Glauco; Reggiani, Angelo; Bandiera, Tiziano; Bertozzi, Fabio; Piomelli, Daniele; European Journal of Medicinal Chemistry; vol. 111; (2016); p. 138 – 159;,
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