Category: 171032-87-4

(L)- or (D)-Valine tert-butylamide grafted on permethylated β-cyclodextrin derivatives as new mixed binary chiral selectors was written by Stephany, O.;Dron, F.;Tisse, S.;Martinez, A.;Nuzillard, J.-M.;Peulon-Agasse, V.;Cardinael, P.;Bouillon, J.-P.. And the article was included in Journal of Chromatography A in 2009.Product Details of 171032-87-4 This article mentions the following:

This work deals with the synthesis of two mixed binary chiral selectors prepared by grafting L– or D-valine tert-butylamide on permethylated cyclodextrin macrocycle. The enantioselective properties of the new chiral selectors diluted in OV11 polysiloxane (35% phenyl- and 65% methylsiloxane) were studied by injections of 117 racemic mixtures The mixed chiral selectors with L-valine and, to a lesser extent with D-valine, have an improved enantioselectivity toward amino acid derivatives by comparison to permethylated cyclodextrin. The enantioseparation capability of these new chiral selectors proved to be slightly less efficient than Chirasil-L-Val (Alltech) for amino acid derivatives, but it was extended to include terpenes, lactones, esters, aliphatic compounds and aryl alcs. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Product Details of 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Asymmetric Reduction of Ketones by the Acetone Powder of Geotrichum candidum was written by Nakamura, K.;Matsuda, T.. And the article was included in Journal of Organic Chemistry in 1998.Safety of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

Aromatic ketones, β-keto esters, and simple aliphatic ketones were reduced with excellent selectivity to the corresponding (S)-alcs. by using the acetone powder of Geotrichum candidum. This method is superior in reactivity and stereoselectivity to reduction by the whole-cell. The exptl. conditions for the reduction system such as ratio of the biocatalyst to the substrate, kinds of coenzymes, alc. for coenzyme regeneration, and buffer, pH, and reaction temperature were investigated, and stability and preservability of the biocatalyst were also examined This method is very convenient for the synthesis of optically pure alcs. on a gram scale. E.g., 2-chloroacetophenone was reduced to (S)-2-ClC₆H₄CH(OH)Me in >99% ee and 94% isolated yield by reduction with the acetone powder of Geotrichum candidum as the catalyst, NAD⁺ as a coenzyme, and Me₂CHOH as the reducing agent in MES [2-(N-morpholine)ethanesulfonic acid-NaOH] buffer. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Safety of (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of (S)-1-(2-Fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In situ formation of ligand and catalyst-application in ruthenium-catalyzed enantioselective reduction of ketones was written by Vaestilae, Patrik;Wettergren, Jenny;Adolfsson, Hans. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2005.Quality Control of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

The direct in situ formation of highly efficient ruthenium-catalysts for the asym. reduction of ketones was obtained by combining chiral ligand building blocks with a ruthenium precursor. A catalyst was formed from a pseudo-dipeptide generated in situ from N-[(1,1-dimethylethoxy)carbonyl]-L-alanine and (S)-1-amino-2-propanol and tetra(chloro)bis(p-cymene)diruthenium. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Quality Control of (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of (S)-1-(2-Fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts