Category: 171032-87-4

Exploiting self-assembly for ligand-scaffold optimization: substrate-tailored ligands for efficient catalytic asymmetric hydroboration was written by Moteki, Shin A.;Takacs, James M.. And the article was included in Angewandte Chemie, International Edition in 2008.Formula: C8H9FO This article mentions the following:

A self-assembled ligand library (SAL XY) affords a wide range of R/S ratios in Rh-catalyzed asym. hydroboration. Ligand-scaffold optimization reveals substrate-tailored ligands that afford high regio- and enantioselectivity for a variety of ortho-substituted styrene derivatives In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Formula: C8H9FO).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C8H9FO

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Alcohol – Wikipedia,
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Rhodium-catalyzed asymmetric transfer hydrogenation of aryl alkyl ketones employing ligands derived from amino acids was written by Wettergren, Jenny;Zaitsev, Alexey B.;Adolfsson, Hans. And the article was included in Advanced Synthesis & Catalysis in 2007.HPLC of Formula: 171032-87-4 This article mentions the following:

The combination of (pentamethylcyclopentadienyl)rhodium dichloride dimer [{RhCl₂Cp*}₂] and pseudodipeptide ligands, formed from N-Boc protected amino acids and amino alcs., resulted in efficient and selective catalysts for the asym. transfer hydrogenation of ketones in 2-propanol. A number of different secondary alcs., e.g., I, were obtained in high yields and in excellent enantioselectivity using these in situ formed catalysts. Deuterium-labeling experiments showed that the hydride transfer reaction occurs via the monohydridic route. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4HPLC of Formula: 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 171032-87-4

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Alcohol – Wikipedia,
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Asymmetric hydrogenation of aromatic ketones catalyzed by achiral monophosphine TPPTS-stabilized Ru in ionic liquids was written by Wang, Jinbo;Feng, Jian;Qin, Ruixiang;Fu, Haiyan;Yuan, Maolin;Chen, Hua;Li, Xianjun. And the article was included in Tetrahedron: Asymmetry in 2007.Recommanded Product: 171032-87-4 This article mentions the following:

Ruthenium nanoparticles generated from ruthenium trichloride and TPPTS [3-(NaSO₃)C₆H₄]₃P and the nonracemic ligand I together act as a catalyst for the enantioselective hydrogenation of aralkyl ketones RCOR¹ (R = Ph, 2-BrC₆H₄, 2-ClC₆H₄, 2-FC₆H₄, 2-MeOC₆H₄, 4-F₃CC₆H₄, 4-MeOC₆H₄; R¹ = Me, Et) in mixtures of imidazolium ionic liquids and water to give nonracemic aralkyl alcs. RCH(OH)R¹ in 48-100% conversions and in 45-85% ee. The effect of temperature, of potassium hydroxide and water concentrations, and of ionic liquid on enantioselectivity and conversion are determined The aralkyl alcs. are easily separated from the catalyst by simple extraction with n-hexane. The catalyst solution in the ionic liquid can be reused six times with some loss in conversion but little loss in enantioselectivity. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Recommanded Product: 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 171032-87-4

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Alcohol – Wikipedia,
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Highly efficient asymmetric hydrogenation of alkyl aryl ketones catalyzed by iridium complexes with chiral planar ferrocenyl phosphino-thioether ligands was written by Le Roux, Erwan;Malacea, Raluca;Manoury, Eric;Poli, Rinaldo;Gonsalvi, Luca;Peruzzini, Maurizio. And the article was included in Advanced Synthesis & Catalysis in 2007.Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

Ir complexes of planar-chiral ferrocenyl phosphine-thioether ligands were tested in the hydrogenation of simple ketones. Optimization of the conditions led to a highly active catalytic system with turnover numbers up to 915 and turnover frequencies up to ∼250 h^-1. Also, very high enantioselectivities (up to > 99%) together with complete conversions were obtained for the asym. hydrogenation of various acetophenones at 10°. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol

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Alcohol – Wikipedia,
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Heterogeneous asymmetric hydrogenation of aromatic ketones enhanced by silanols on highly monodispersed silica spheres was written by Li, Chun;Zhang, Lin;Liu, Hailong;Zheng, Xueli;Fu, Haiyan;Chen, Hua;Li, Ruixiang. And the article was included in Catalysis Communications in 2014.HPLC of Formula: 171032-87-4 This article mentions the following:

A triphenylphosphine-stabilized Ir/SiO₂ catalyst modified by a chiral diamine was synthesized with four silica spheres as support for the asym. hydrogenation of aromatic ketones. The H-bond between substrate and silanols and the interaction between substrate and modifier commonly affected the steric configuration of asym. hydrogenation of aromatic ketones. With the silanols increasing, the activity of asym. hydrogenation significantly increased. This is the first report of heterogeneous asym. hydrogenation of aromatic ketones enhanced by silanols on highly monodispersed silica spheres with > 99.9% ee and > 99% conversion. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4HPLC of Formula: 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 171032-87-4

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Alcohol – Wikipedia,
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Synthesis and application of chiral N,N’-dialkylated cyclohexanediamine for asymmetric hydrogenation of aryl ketones was written by Ma, Meng-Lin;Ren, Chuan-Hong;Lv, Ya-Jing;Chen, Hua;Li, Xian-Jun. And the article was included in Chinese Chemical Letters in 2011.Product Details of 171032-87-4 This article mentions the following:

Chiral N,N’-dialkylated cyclohexanediamine derived ligands were synthesized and used in the asym. hydrogenation of aryl ketones. Optically active alcs. with up to 90% enantiomeric excess were obtained in high yields. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Product Details of 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 171032-87-4

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Alcohol – Wikipedia,
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Enantioselective hydrogenation of aromatic ketones: structural effects was written by Hess, Reto;Mallat, Tamas;Baiker, Alfons. And the article was included in Journal of Catalysis in 2003.Safety of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

Enantioselective hydrogenation of acetophenone derivatives demonstrates the potential of the Pt-cinchona system in the synthesis of chiral alcs. that possess no functional group in the α-position to the CH-OH group. Electron-withdrawing functional groups in the aromatic ring increased the reaction rate and enantiomeric excess (ee), and the position of the group (o-, m-, or p-) was also important. In the hydrogenation of 3,5-di(trifluoromethyl)acetophenone under ambient conditions, 60% ee was obtained, though the special role of reaction parameters has not been investigated yet. Addition of cinchonidine slowed down all hydrogenation reactions-an unprecedented behavior for chirally modified Pt. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Safety of (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Safety of (S)-1-(2-Fluorophenyl)ethanol

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Cinchona-Alkaloid-Derived NNP Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones was written by Zhang, Lin;Zhang, Ling;Chen, Qian;Li, Linlin;Jiang, Jian;Sun, Hao;Zhao, Chong;Yang, Yuanyong;Li, Chun. And the article was included in Organic Letters in 2022.Name: (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

Herein, a series of novel and easily accessed cinchona-alkaloid-based NNP ligands I [R = cyclohexyl, Ph, 2-MeOC₆H₄, etc.; R¹ = H, MeO] was developed in two steps. By combining [Ir(COD)Cl]₂, 39 ketones including aromatic, heteroaryl, and alkyl ketones were hydrogenated, all affording valuable chiral secondary alcs. with 96.0-99.9% ee. A plausible reaction mechanism was discussed by NMR, HRMS, DFT and an activating model involving trihydride was verified. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Name: (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: (S)-1-(2-Fluorophenyl)ethanol

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Cryptococcus laurentii as a new biocatalyst for the asymmetric reduction of substituted acetophenones was written by Kurbanoglu, Esabi B.;Zilbeyaz, Kani;Kurbanoglu, Namudar I.. And the article was included in Tetrahedron: Asymmetry in 2011.Quality Control of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

Immobilized cells of the yeast Cryptococcus laurentii attached to calcium alginate have been introduced as a biocatalyst in the asym. reduction of substituted acetophenones. Forty isolates of microorganisms belonging to this taxonomical yeast group were isolated from various samples. Immobilized cells of these isolates were screened as reducing agents for acetophenone 1a to its corresponding alc. 1b. The four best isolates were selected and identified as Rhodotorula glutinis, Saccharomyces cerevisiae, Hansenula capsulata and C. laurentii by the VITEK 2 compact system. The use of the first three microorganisms is well known and therefore it was decided to explore C. laurentii as a new biocatalyst in organic reactions. The aim was to determine whether C. laurentii could be used to catalyze the bio-reduction of ketones to obtain the (R)- or (S)-isomer of the alc. with high enantiomeric purity. The isolate C. laurentii EBK-19 was selected for further experiments and studied in detail. More than 70% of the ketones tested were obtained with almost complete conversion (100%), while all the ketones tested were converted to the corresponding (S)-isomer-alcs. in up to > 99% enantiomeric excess (ee) under very mild reaction conditions. Amongst the chiral alcs. obtained, the enantiopure 1b obtained from the complete conversion of 1a using C. laurentii EBK-19 was produced on a large scale (9.3 g) using an immobilized cell reaction system. In conclusion, we have presented C. laurentii as a promising biocatalyst for the production of optically active phenylethanols. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Quality Control of (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of (S)-1-(2-Fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Exploiting the enzymatic machinery of Arthrobacter atrocyaneus for oxidative kinetic resolution of secondary alcohols was written by Silva, Camila R.;Souza, Juliana C.;Araujo, Lidiane S.;Kagohara, Edna;Garcia, Thais P.;Pelizzari, Vivian H.;Andrade, Leandro H.. And the article was included in Journal of Molecular Catalysis B: Enzymatic in 2012.Recommanded Product: 171032-87-4 This article mentions the following:

We evaluated Arthrobacter atrocyaneus (R1AF57) as producer of oxidoreductases for oxidative kinetic resolution of racemic secondary alcs. via oxidation reaction. This bacterium was isolated from Amazon soil samples using medium enriched with (RS)-1-(4-methylphenyl)ethanol as a carbon source. The kinetic resolution of several secondary alcs. through enantioselective oxidation mediated by resting cells and growing cells of A. atrocyaneus was efficiently achieved for the most alcs. In general, it was possible to obtain only the (S)-enantiomer from (RS)-1-arylethanols. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Recommanded Product: 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts