171032-87-4 Archives - Alcohols-buliding-blocks

Kang, Guowei et al. published their research in Catalysis Communications in 2014 | CAS: 171032-87-4

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

Imidazolium ion tethered TsDPENs as efficient water-soluble ligands for rhodium catalyzed asymmetric transfer hydrogenation of aromatic ketones was written by Kang, Guowei;Lin, Silong;Shiwakoti, Atul;Ni, Bukuo. And the article was included in Catalysis Communications in 2014.Category: alcohols-buliding-blocks This article mentions the following:

An imidazolium ion tethered TsDPEN has been synthesized readily and used as a water-soluble ligand for [Cp*RhCl₂]₂ catalyzed asym. transfer hydrogenation (ATH) of aromatic ketones in water. This process provided secondary alcs. in moderate to excellent conversions (up to 100%) with high enantioselectivity (up to 98% ee) under mild reaction conditions without adding any surfactants. The catalytic system is highly effective with the substrate to catalyst (S/C) ratio of 500 and low hydride donor loading of 1.5 equivalent of HCO₂Na. The procedure presented is simple and makes this method suitable for practical use. The synthesis of the target compounds was achieved using [[[[[(amino)diphenylethyl]amino]sulfonyl]phenyl]methyl]imidazolium salt and a rhodium complex as catalyst combination. The catalyst was prepared using N-[(1S,2S)-2-amino-1,2-diphenylethyl]carbamic acid 1,1-dimethylethyl ester and imidazole derivatives as starting materials. Under optimized conditions di-渭-(chloro)dichlorobis[(1,2,3,4,5-畏)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]dirhodium was used as a catalyst. Transfer hydrogenation of 1-(phenyl)ethanone (acetophenone) derivatives gave (伪S)-伪-(methyl)benzenemethanol (chiral benzyl alc.) derivatives In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Category: alcohols-buliding-blocks).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zilbeyaz, Kani et al. published their research in Chirality in 2010 | CAS: 171032-87-4

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 171032-87-4

Highly enantiomeric reduction of acetophenone and its derivatives by locally isolated Rhodotorula glutinis was written by Zilbeyaz, Kani;Kurbanoglu, Esabi B.. And the article was included in Chirality in 2010.SDS of cas: 171032-87-4 This article mentions the following:

Ninety isolates of microorganisms belonging to different taxonomical groups (30 bacteria, 20 yeast, and 40 fungi) were previously isolated from various samples. These isolates were screened as reducing agents for acetophenone 1a to phenylethanol 2a. It was found that the isolate EBK-10 was the most effective biocatalyst for the enantioselective bioreduction of acetophenone. This isolate was identified as Rhodotorula glutinis by the VITEK 2 Compact system. The various parameters (pH 6.5, temperature 32掳C, and agitation 200 rpm) of the bioreduction reaction was optimized, which resulted in conversions up to 100% with >99% enantiomeric excesses (ee) of the S-configuration. The preparative scale bioreduction of acetophenone 1a by R. glutinis EBK-10 gave (S)-1-phenylethanol 2a in 79% yield, complete conversion, and >99% ee. In addition, R.glutinis EBK-10 successfully reduced various substituted acetophenones. Chirality, 2010. 漏 2010 Wiley-Liss, Inc. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4SDS of cas: 171032-87-4).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Garrett, Christine E. et al. published their research in Tetrahedron: Asymmetry in 2002 | CAS: 171032-87-4

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.HPLC of Formula: 171032-87-4

The enantioselective reduction of 2′-fluoroacetophenone utilizing a simplified CBS-reduction procedure was written by Garrett, Christine E.;Prasad, Kapa;Repic, Oljan;Blacklock, Thomas J.. And the article was included in Tetrahedron: Asymmetry in 2002.HPLC of Formula: 171032-87-4 This article mentions the following:

A practical, non-enzymic, catalytic process was developed for the enantioselective reduction of 2′-fluoroacetophenone. A number of catalysts were screened for the oxazaborolidine-type reduction of this ketone to obtain an optimized system. It was shown that the simplest procedure uses the catalyst formed in situ from (S)-伪,伪-diphenyl-2-pyrrolidinemethanol and borane-diethylaniline. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4HPLC of Formula: 171032-87-4).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Sensheng et al. published their research in Organic Letters in 2018 | CAS: 171032-87-4

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: (S)-1-(2-Fluorophenyl)ethanol

Transformation of Alkynes into Chiral Alcohols via TfOH-Catalyzed Hydration and Ru-Catalyzed Tandem Asymmetric Hydrogenation was written by Liu, Sensheng;Liu, Huan;Zhou, Haifeng;Liu, Qixing;Lv, Jinliang. And the article was included in Organic Letters in 2018.Recommanded Product: (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

A novel full atom-economic process for the transformation of alkynes into chiral alcs. by TfOH-catalyzed hydration coupled with Ru-catalyzed tandem asym. hydrogenation in TFE under simple conditions has been developed. A range of chiral alcs. was obtained with broad functional group tolerance, good yields, and excellent stereoselectivities. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Recommanded Product: (S)-1-(2-Fluorophenyl)ethanol).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

ilbeyaz, Kani et al. published their research in Chirality in 2010 | CAS: 171032-87-4

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C8H9FO

Production of (R)-1-phenylethanols through bioreduction of acetophenones by a new fungus isolate Trichothecium roseum was written by ilbeyaz, Kani;Taskin, Mesut;Kurbanoglu, Esabi B.;Kurbanoglu, Namudar I.;Kilic, Hamdullah. And the article was included in Chirality in 2010.COA of Formula: C8H9FO This article mentions the following:

A total of 120 fungal strains were isolated from soil samples and evaluated in the bioreduction of substituted acetophenones to the corresponding (R)-alcs. Among these strains, isolate Trichothecium roseum EBK-18 was highly effective in the production of (R)-alcs. with excellent enantioselectivity (ee > 99%). Gram scale preparation of (R)-1-phenylethanol is reported. Chirality 2010. 漏 2009 Wiley-Liss, Inc. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4COA of Formula: C8H9FO).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kang, Guowei et al. published their research in Catalysis Communications in 2014 | CAS: 171032-87-4

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

An imidazolium ion tethered TsDPEN has been synthesized readily and used as a water-soluble ligand for [Cp*RhCl₂]₂ catalyzed asym. transfer hydrogenation (ATH) of aromatic ketones in water. This process provided secondary alcs. in moderate to excellent conversions (up to 100%) with high enantioselectivity (up to 98% ee) under mild reaction conditions without adding any surfactants. The catalytic system is highly effective with the substrate to catalyst (S/C) ratio of 500 and low hydride donor loading of 1.5 equivalent of HCO₂Na. The procedure presented is simple and makes this method suitable for practical use. The synthesis of the target compounds was achieved using [[[[[(amino)diphenylethyl]amino]sulfonyl]phenyl]methyl]imidazolium salt and a rhodium complex as catalyst combination. The catalyst was prepared using N-[(1S,2S)-2-amino-1,2-diphenylethyl]carbamic acid 1,1-dimethylethyl ester and imidazole derivatives as starting materials. Under optimized conditions di-μ-(chloro)dichlorobis[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]dirhodium was used as a catalyst. Transfer hydrogenation of 1-(phenyl)ethanone (acetophenone) derivatives gave (αS)-α-(methyl)benzenemethanol (chiral benzyl alc.) derivatives In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Category: alcohols-buliding-blocks).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zilbeyaz, Kani et al. published their research in Chirality in 2010 | CAS: 171032-87-4

Ninety isolates of microorganisms belonging to different taxonomical groups (30 bacteria, 20 yeast, and 40 fungi) were previously isolated from various samples. These isolates were screened as reducing agents for acetophenone 1a to phenylethanol 2a. It was found that the isolate EBK-10 was the most effective biocatalyst for the enantioselective bioreduction of acetophenone. This isolate was identified as Rhodotorula glutinis by the VITEK 2 Compact system. The various parameters (pH 6.5, temperature 32°C, and agitation 200 rpm) of the bioreduction reaction was optimized, which resulted in conversions up to 100% with >99% enantiomeric excesses (ee) of the S-configuration. The preparative scale bioreduction of acetophenone 1a by R. glutinis EBK-10 gave (S)-1-phenylethanol 2a in 79% yield, complete conversion, and >99% ee. In addition, R.glutinis EBK-10 successfully reduced various substituted acetophenones. Chirality, 2010. © 2010 Wiley-Liss, Inc. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4SDS of cas: 171032-87-4).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Garrett, Christine E. et al. published their research in Tetrahedron: Asymmetry in 2002 | CAS: 171032-87-4

A practical, non-enzymic, catalytic process was developed for the enantioselective reduction of 2′-fluoroacetophenone. A number of catalysts were screened for the oxazaborolidine-type reduction of this ketone to obtain an optimized system. It was shown that the simplest procedure uses the catalyst formed in situ from (S)-α,α-diphenyl-2-pyrrolidinemethanol and borane-diethylaniline. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4HPLC of Formula: 171032-87-4).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Sensheng et al. published their research in Organic Letters in 2018 | CAS: 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

ilbeyaz, Kani et al. published their research in Chirality in 2010 | CAS: 171032-87-4

A total of 120 fungal strains were isolated from soil samples and evaluated in the bioreduction of substituted acetophenones to the corresponding (R)-alcs. Among these strains, isolate Trichothecium roseum EBK-18 was highly effective in the production of (R)-alcs. with excellent enantioselectivity (ee > 99%). Gram scale preparation of (R)-1-phenylethanol is reported. Chirality 2010. © 2009 Wiley-Liss, Inc. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4COA of Formula: C8H9FO).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts