Category: 171011-37-3

Application of 171011-37-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 171011-37-3, name is (4-Bromo-1,2-phenylene)dimethanol. A new synthetic method of this compound is introduced below.

Step 2: Synthesis of (5-bromo-2-(chloromethyl)phenyl)methanol A flask was charged with (4-bromo-1,2-phenylene)dimethanol (4.00 g, 18.4 mmol, 1.00 equiv) and hydrochloric acid (25 mL). The resulting solution was stirred for 15 min at 70 C and quenched with water (50 mL). The mixture was extracted with EtOAc (2 x 80 mL) and the organic layers were combined, dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was chromatographed on a silica gel column with EtOAc/petroleum ether (1/8) to provide 2.70 g (62% yield) of (5-bromo-2-(chloromethyl)phenyl)methanol as an off-white solid.1H NMR (300 MHz, DMSO-d6) ^ 7.64- 7.66 (m, 1H), 7.45- 7.49 (m, 1H), 7.36 (d, J = 8.1 Hz, 1H), 5.40- 5.45 (m, 1H), 4.78 (s, 2H), 4.66 (d, J = 4.5 Hz, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,171011-37-3, (4-Bromo-1,2-phenylene)dimethanol, and friends who are interested can also refer to it.

Reference:
Patent; ABIDE THERAPEUTICS, INC.; BUZARD, Daniel J.; SHAGHAFI, Michael B.; CISAR, Justin S.; GRICE, Cheryl A.; JONES, Todd K.; WEBER, Olivia D.; (277 pag.)WO2017/197192; (2017); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 171011-37-3, name is (4-Bromo-1,2-phenylene)dimethanol, molecular formula is C8H9BrO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: (4-Bromo-1,2-phenylene)dimethanol

To a solution of (COCl)2 (2.6 equiv.) in anhydrous DCM (1.4 mL per mmol of diol) was added dropwise a solution of anhydrous DMSO (5.2 equiv.) in anhydrous DCM (2.2 mL per mmol of diol) at -78 C and under a nitrogen atmosphere. After 10 min stirring at -78 C, a solution of diol (1.0 equiv.) in anhydrous DCM (2.2 mL per mmol of diol) was added at this temperature. The reaction mixture was stirred at -78 C for 1h under a nitrogen atmosphere before Et3N (1.4 mL per mmol of diol) was added dropwise. The reaction mixture was warmed to rt and stirred for 2-18 h under a nitrogen atmosphere. The reaction was then quenched by addition of H2O. The organics were extracted with DCM, combined, washed with water, washed with brine, dried over MgSO4 and concentrated in vacuo to afford the desired o-phthaldialdehyde.

With the rapid development of chemical substances, we look forward to future research findings about 171011-37-3.

Reference:
Article; D’Hollander, Agathe C.A.; Westwood, Nicholas J.; Tetrahedron; vol. 74; 2; (2018); p. 224 – 239;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 171011-37-3, name is (4-Bromo-1,2-phenylene)dimethanol, molecular formula is C8H9BrO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: (4-Bromo-1,2-phenylene)dimethanol

To a solution of (COCl)2 (2.6 equiv.) in anhydrous DCM (1.4 mL per mmol of diol) was added dropwise a solution of anhydrous DMSO (5.2 equiv.) in anhydrous DCM (2.2 mL per mmol of diol) at -78 C and under a nitrogen atmosphere. After 10 min stirring at -78 C, a solution of diol (1.0 equiv.) in anhydrous DCM (2.2 mL per mmol of diol) was added at this temperature. The reaction mixture was stirred at -78 C for 1h under a nitrogen atmosphere before Et3N (1.4 mL per mmol of diol) was added dropwise. The reaction mixture was warmed to rt and stirred for 2-18 h under a nitrogen atmosphere. The reaction was then quenched by addition of H2O. The organics were extracted with DCM, combined, washed with water, washed with brine, dried over MgSO4 and concentrated in vacuo to afford the desired o-phthaldialdehyde.

With the rapid development of chemical substances, we look forward to future research findings about 171011-37-3.

Reference:
Article; D’Hollander, Agathe C.A.; Westwood, Nicholas J.; Tetrahedron; vol. 74; 2; (2018); p. 224 – 239;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 171011-37-3, (4-Bromo-1,2-phenylene)dimethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 171011-37-3, blongs to alcohols-buliding-blocks compound. Recommanded Product: 171011-37-3

(1) In 380 ml of diethyl ether was dissolved 19.0 g of 1-bromo-3,4-di(hydroxymethyl)benezene and to the solution was added 112 g of phosphorus tribromide under ice-cooling, after which the resulting mixture was allowed to stand for 3 days. The reaction mixture was added to 1,000 ml of ice water and the pH was adjusted to 7 with sodium hydrogencarbonate, followed by extraction with 1,000 ml of ethyl acetate. The organic layer thus obtained was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then distilled under reduced pressure to remove the solvent, whereby 28.5 g of 1-bromo-3,4-di(bromomethyl)benzene were obtained as colorless crystals.

The synthetic route of 171011-37-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Toyama Chemical Co., Ltd.; US6025370; (2000); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 171011-37-3, name is (4-Bromo-1,2-phenylene)dimethanol. A new synthetic method of this compound is introduced below., SDS of cas: 171011-37-3

After dissolving Compound 3 (5.2 g, 23.9 mmol) in methylene chloride (50 milliliter), followed by adding N-bromosuccinimide (12.8 g, 71.7 mmol) at room temperature, and then the resultant solution was stirred for 6 hours. Water (200 milliliter) was poured in the resultant reaction solution, and the deposited solid was washed by ethanol, and as a result, Compound 4 was obtained. Product Amount: 6.9 g, Yield: 84 %

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 171011-37-3, (4-Bromo-1,2-phenylene)dimethanol.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; EP1659129; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 171011-37-3, (4-Bromo-1,2-phenylene)dimethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: (4-Bromo-1,2-phenylene)dimethanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: (4-Bromo-1,2-phenylene)dimethanol

General procedure: In a typical experiment, a round bottom flask containing 4-6mL of acetonitrile/water mixture (1:1) was charged with 0.5-1.0mmol of the diol, 5mol% of TetMe-IA, and oxone (2equiv). The resulting mixture was stirred at rt for benzylic diols and at 45C for aliphatic diols. At the end of the reaction, as judged from TLC analysis, little water was added to dissolve the inorganic salts, and the organic matter was extracted with EtOAc at least two times. The combined extract was dried over anhydrous Na2SO4, concentrated in vacuo to obtain the crude product, which was subjected to silica-gel column chromatography using ethyl acetate/pet ether to isolate the pure product.

The synthetic route of 171011-37-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jhulki, Samik; Seth, Saona; Mondal, Manas; Moorthy, Jarugu Narasimha; Tetrahedron; vol. 70; 13; (2014); p. 2286 – 2293;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts