Category: 16545-68-9

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16545-68-9, name is Cyclopropanol, molecular formula is C3H6O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C3H6O

A solution of cyclopropanol (0.060 g, 1.03 mmol) in CH2CI2 (2 mL) was cooled to 0 C, treated with K2CO3 (0.43 g, 3.10 mmol) followed by phosgene (20% wt in toluene, 0.54 mL, 1.03 mmol), and stirred vigorously overnight at 0 C to room temperature. Unreacted phosgene was removed by purging the solution with N2 gas (passed through a KOH solution to dry) for 30 min. The reaction mixture was filtered through anhydrous MgS04, and concentrated at 0 C to afford cyclopropyl chloroformate as a colorless oil (~0.3 mL) that was used directly as a toluene solution for the next step (cyclopropyl chloroformate/cyclopropanol = 1:0.19, theoretical concentration = 2.8 M). 1 H NMR (400 MHz, CDCL) d 4.41-3.36 (m, 1 H), 0.98-0.82 (m, 4 H); 13C NMR (100 MHz, CDCL) d 151.3, 56.2, 5.49.

With the rapid development of chemical substances, we look forward to future research findings about 16545-68-9.

Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; WIPF, Peter; (79 pag.)WO2019/203951; (2019); A1;,
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Reference of 16545-68-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16545-68-9, name is Cyclopropanol, molecular formula is C3H6O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2,6-dichloro-9-cyclopropylpurine2,6-Dichloropurine (1 mmol), triphenylphosphine (1.3 mmol), tetrahydrofurane (5 ml) and cyclopropanol (5 mmol) were stirred at it under nitrogen to give clear yellowish solution, which was then cooled to 0 C and diisopropyldiazadicarboxylate (DIAD; 1.3 mmol) was added via syringe. The reaction mixture was then stirred at rt for 12 h. After evaporation of the solvents the product was extracted with diethylether and purified by column chromatography (silicagel, 1% MeOH in CHCl3). Crystallization from methanol gave the product in yield 35 %, mp 121-124 C.

According to the analysis of related databases, 16545-68-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UNIVERZITA PALACKEHO V OLOMOUCI; BIOPATTERNS s.r.o.; ZATLOUKAL, Marek; KRYSTOF, Vladimir; HAVLICEK, Libor; POPA, Igor; DOLEZAL, Karel; STRNAD, Miroslav; WO2010/139289; (2010); A1;,
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Adding a certain compound to certain chemical reactions, such as: 16545-68-9, Cyclopropanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Cyclopropanol, blongs to alcohols-buliding-blocks compound. name: Cyclopropanol

Diisopropylethylamine (0.142 mL, 0.811 mmol), HBTU (0.184 g, 0.486 mmol), and crude cyclopropanol (0.0470 g, 0.811 mmol) were added to a solution of 2-(2-(3-(4-(dimethylamino)piperidin-1-yl)-3-oxopropyl)-1H-imidazol-1-yl)acetic acid (0.100 g, 0.324 mmol) in chloroform (6.0 mL) at room temperature, and the reaction liquid was stirred at the same temperature for 16 hours. Hydrochloric acid (1.0 N) was added to the reaction liquid, and then the reaction liquid was back-extracted. A saturated aqueous solution of sodium hydrogencarbonate was added to the obtained aqueous layer for neutralization, and then the resulting mixture was extracted with chloroform. The organic layer was washed with a 10% aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure to obtain cyclopropyl 2-(2-(3-(4-(dimethylamino)piperidin-1-yl)-3-oxopropyl)-1H-imidazol-1-yl)acetate (0.0610 g, 0.175 mmol, 54%) (hereinafter referred to as a ?compound of Example 44?) as a colorless oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,16545-68-9, Cyclopropanol, and friends who are interested can also refer to it.

Reference:
Patent; TORAY INDUSTRIES, INC.; MORITA, YASUHI; IZUMIMOTO, NAOKI; ISEKI, KATSUHIKO; IWANO, SHUNSUKE; UDAGAWA, SHUJI; MIYOSHI, TOMOYA; OSADA, YUJI; KOREEDA, TETSURO; MURAKAMI, MASANORI; SHIRAKI, MOTOHIRO; TAKAHASHI, KEI; OSHIDA, KEIYU; (177 pag.)TW2016/2093; (2016); A;,
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Adding a certain compound to certain chemical reactions, such as: 16545-68-9, Cyclopropanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Cyclopropanol, blongs to alcohols-buliding-blocks compound. Safety of Cyclopropanol

Cyclopropanol (113 mg,1.94 mmol) was added to NaHMDS (1 M,2.07 mL, 2.07 mmol) at 0 C under nitrogen. The mixture wasstirred at 0 C for 0.5 h. Compound 76 (300 mg, 646 mmol) in THF(3 mL) was then added dropwise. The mixture was stirred at 25 Cfor 1 h. TLC showed that starting material 76 was depleted. Thereaction was quenched with aqueous saturated ammonium chloride solution, extracted with ethyl acetate (20 mL 3), and washedwith brine (20 mL 2). The organic layer was dried with anhydroussodium sulfate and concentrated to give a residue. The residue wasdissolved in acetonitrile (3 mL) and purified by preparative HPLC togive compound 61 (82 mg, 208 mmol, 32.2% yield, 98.6% purity). 1HNMR (400 MHz, chloroform-d) d (ppm) 7.38e7.86 (m, 7H), 5.32 (br,s, 1H), 4.51e4.65 (m, 1H), 4.13e4.24 (m, 1H), 3.68e3.84 (m, 4H),3.08e3.15 (m, 2H),1.61 (d, J 4.0 Hz, 6H), 0.88 (br, s, 2H), 0.74e0.75(m, 2H). 13C NMR (126 MHz, DMSO-d6) d (ppm) 168.34, 153.56,140.90, 140.77, 140.59, 137.94, 135.48, 131.21, 130.97, 130.75, 130.55,129.25, 128.99, 128.83, 127.92, 127.71, 126.78, 119.09, 118.30, 118.08,117.55, 68.82, 68.11, 67.95, 53.75, 30.61, 30.02, 29.95, 29.39, 22.41,5.79, 5.76. ESI-TOF HRMS: m/z 395.1974 (C23H26N2O4 H requires395.1973).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,16545-68-9, Cyclopropanol, and friends who are interested can also refer to it.

Reference:
Article; Lin, Wenwei; Yang, Lei; Chai, Sergio C.; Lu, Yan; Chen, Taosheng; European Journal of Medicinal Chemistry; vol. 108; (2016); p. 505 – 528;,
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Application of 16545-68-9 ,Some common heterocyclic compound, 16545-68-9, molecular formula is C3H6O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 1: 1-bromo-5-cyclopropyloxy-2-methyl-4-nitrobenzene 1-bromo-5-fluoro-2-methyl-4-nitrobenzene (70g , 0.3mol), freshly prepared cyclopropanol diethyl ether complex (23g, ?0.4mol) and N, N- dimethylformamide (260mL) were added into a 500mL reaction flask. Sodium tert-butoxide (35g, 0.36mol) was added slowly thereinto at 0Cand the reaction mixture was stirred at 0C for 1.5 hours. After completion of the reaction, the reaction mixture was poured into ice water slowly, and the precipitated solid was filtered to obtain the crude product. The filter cake was then washed with a lot of water and dried through air to obtain the title compound (yellow solid, 78g, 96%), which may be used directly for the subsequent reaction. (MS: [M+1] none)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16545-68-9, its application will become more common.

Reference:
Patent; Beijing Pearl Biotechnology Limited Liability Company; DONG, Jiaqiang; ZHONG, Boyu; YUAN, Hongbin; SHI, Quan; CHU, Shaosong; ZHANG, Deyi; ZHANG, Ruihao; (219 pag.)EP3150592; (2017); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16545-68-9, name is Cyclopropanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C3H6O

Methyl 2-([1-[(2-chlorophenyl)methyl]-5-(4-cyclopropoxythien-2-yl)-1H-pyrazol-3-yl]methoxy)-2-methylpropanoate To a solution of the product from the previous step (350 mg, 0.72 mmol, 1.00 equiv) in dioxane (10 mL) was added stepwise Cs2CO3 (473 mg, 1.45 mmol, 2.00 equiv), 2nd Generation XantPhos precatalyst (322 mg, 0.36 mmol, 0.50 equiv), and cyclopropanol (168 mg, 2.89 mmol, 4.00 equiv). The final reaction mixture was irradiated with microwave radiation for 1 h at 85 C. The resulting solution was diluted with 100 mL of EtOAc. The resulting mixture was washed with 2¡Á100 mL of brine. The mixture was dried over anhydrous Na2SO4 and concentrated under vacuum. The residue was applied onto a silica gel column with EtOAc/petroleum ether (1:2). This resulted in the title compound as a yellow oil (150 mg, 45%).

With the rapid development of chemical substances, we look forward to future research findings about 16545-68-9.

Reference:
Patent; Vettore, LLC; PARNELL, Kenneth Mark; MCCALL, John; ROMERO, Donna; (172 pag.)US2018/162822; (2018); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16545-68-9, name is Cyclopropanol. A new synthetic method of this compound is introduced below., Recommanded Product: 16545-68-9

Cyclopropanol (340mg, 5.85mmol) dissolved in tetrahydrofuran (10 mL), compound a87 (1,00g, 5.32mmol), potassium carbonate (1.62g, 11.7mmol)And 18-crown ether -6 (4.22g, 16.0mmol) was added, and the mixture was stirred for 3 h at 60C . Water and 1.0mol / L hydrochloric acid solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel chromatography – (hexane-ethyl acetate) to give the compound a88 (254mg, 21% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 16545-68-9, Cyclopropanol.

Reference:
Patent; Shionogi & Co., Ltd.; Oyabu, kyoju; Kurahashi, Kana; Nishiura, Yuji; Kato, Manabu; Miyazaki, Keisuke; Wada, Toshihiro; Sasaki, Giichi; Iwatsu, Masafumi; (167 pag.)JP2016/79168; (2016); A;,
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