16545-68-9 Archives - Alcohols-buliding-blocks

Zubrytski, Dzmitry M. team published research in Molecules in 2021 | 16545-68-9

16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., Recommanded Product: Cyclopropanol

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Recommanded Product: Cyclopropanol

Zubrytski, Dzmitry M.;Elek, G. Abor Zolt An;Lopp, Margus;Kananovich, Dzmitry G. research published 《 Generation of mixed anhydrides via oxidative fragmentation of tertiary cyclopropanols with phenyliodine(III) dicarboxylates》, the research content is summarized as follows. Oxidative fragmentation of tertiary cyclopropanols with phenyliodine(III) dicarboxylates in aprotic solvents (dichloromethane, chloroform, toluene) produces mixed anhydrides. The fragmentation reaction is especially facile with phenyliodine(III) reagents bearing electron-withdrawing carboxylate ligands (trifluoroacetyl, 2,4,6-trichlorobenzoyl, 3-nitrobenzoyl), and affords 95 -98% yields of the corresponding mixed anhydride products. The latter can be straightforwardly applied for the acylation of various nitrogen, oxygen and sulfur-centered nucleophiles (primary and secondary amines, hydroxylamines, primary alcs., phenols, thiols). Intramol. acylation yielding macrocyclic lactones can also be performed. The developed transformation has bolstered the synthetic utility of cyclopropanols as pluripotent intermediates in diversity-oriented synthesis of bioactive natural products and their synthetic congeners. For example, it was successfully applied for the last-stage modification of a cyclic peptide to produce a precursor of a known histone deacetylase inhibitor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Ze team published research in Pest Management Science in 2022 | 16545-68-9

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 16545-68-9, formula is C3H6O, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Application of C3H6O

Zhang, Ze;Sun, Pengwei;Zhao, Jiahui;Zhang, Hongyuan;Wang, Xinyao;Li, Linshan;Xiong, Lixia;Yang, Na;Li, Yuxin;Yuchi, Zhiguang;Li, Zhengming research published 《 Design, synthesis and biological activity of diamide compounds based on 3-substituent of the pyrazole ring》, the research content is summarized as follows. Diamide insecticides have attracted significant attention due to their high efficacy and low toxicity to non-target organisms since they were introduced to the market. In order to tackle the problems of insecticide resistance and ecol. safety, 16 novel nitrobenzene substituted anthranilic diamides with ester, hydroxyl or sulfonyl at the 3-position of the pyrazole ring were designed and synthesized. All of these compounds possessed good activity against the ryanodine receptor (RyR) from Spodoptera frugiperda and relatively lower activity against mammalian RyR1, showing a better insect-selectivity compared to chlorantraniliprole in a cell-based assay. The mol. docking anal. predicted the binding conformations of these compounds, which showed a good correlation between the insecticidal activity and the binding scores. In vitro studies using a calcium imaging method demonstrated that the novel compounds could not only activate the RyR but may also target the dihydropyridine receptor on the plasma membrane of insect neurons, implicating a similar but not same mode of action. Substituted anthranilic diamides with an ester at the 3-position of the pyrazole ring exhibited a promising insecticidal activity and better insect-selectivity, which provided insight into the rational design of a new generation of effective diamide insecticides.

Referemce:
Alcohol – Wikipedia,
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Zhang, Juntian team published research in Organic Letters in 2019 | 16545-68-9

Zhang, Juntian;Hoye, Thomas R. research published 《 Divergent Reactivity during the Trapping of Benzynes by Glycidol Analogs: Ring Cleavage via Pinacol-Like Rearrangements vs Oxirane Fragmentations》, the research content is summarized as follows. Hydroxy-containing cyclic ethers react with thermally generated benzynes to produce aryl ethers. Diverse reactivity was observed Cleavage of the cyclic ether was involved in most of the pathways. The transformations are rationalized via initial formation of oxonium ion-containing 1,3-zwitterions arising from preferential nucleophilic attack on the benzyne by the ether oxygen. Pinacol-like rearrangements, including ring expansion, to yield aldehydes or ketones and oxirane fragmentations to generate aryl enol ethers were main competing events.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Peilong team published research in Bioorganic & Medicinal Chemistry Letters in 2015 | 16545-68-9

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 16545-68-9, formula is C3H6O, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Reference of 16545-68-9

Zhang, Peilong;Dong, Jiaqiang;Zhong, Boyu;Zhang, Deyi;Jin, Can;Meng, Xuejing;Sun, Desheng;Xu, Xiangyuan;Zhou, Yong;Liang, Zhi;Ji, Minghua;Li, Hailong;Xu, Tao;Song, Guowei;Zhang, Ling;Chen, Gang;Yuan, Hongbin;Shih, Joe;Zhang, Ruihao;Hou, Guojun;Jin, Ying;Yang, Qiong research published 《 Discovery of 2-arylamino-4-(1-methyl-3-isopropylsulfonyl-4-pyrazol-amino)pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors》, the research content is summarized as follows. A new series of 2,4-diamino pyrimidine derivatives with a sulfone-substituted pyrazole right side-chain were discovered as potent anaplastic lymphoma kinase inhibitors. Structure-activity relationship of the left side-chain on Ph substitutions were explored which delivered many potent ALK inhibitors. Among them, I showed favorable pharmacokinetic profiles in rats and dogs together with significant antitumor efficacy in EML4-ALK fusion xenograft model.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Si-Xuan team published research in Journal of Organic Chemistry in 2021 | 16545-68-9

Quality Control of 16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Zhang, Si-Xuan;Ding, Yan;Wang, Jun-Jie;Shen, Chuanji;Zhou, Xiaocong;Chu, Xue-Qiang;Ma, Mengtao;Shen, Zhi-Liang research published 《 Titanium(IV)-Mediated Ring-Opening/Dehydroxylative Cross-Coupling of Diaryl-Substituted Methanols with Cyclopropanol Derivatives》, the research content is summarized as follows. A titanium(IV)-mediated ring-opening/dehydroxylative cross-coupling of diaryl-substituted methanols R(R¹)C(OH)R² (R = Ph, 2-methylphenyl, 4-iodophenyl, naphthalen-1-yl, etc.; R¹ = H, Ph, 4-methylphenyl, 4-chlorophenyl; R² = Ph, 4-methoxyphenyl, 4-fluorophenyl, etc.) with a (1-ethoxycyclopropoxy)trimethylsilane was developed. The reactions proceeded efficiently to provide synthetically useful γ,γ-diaryl esters R(R¹)C((CH₂)₂C(O)OCH₂CH₃)R² in moderate to good yields, which could be applied to the functionalization of complex mols. I and II derived from bioactive fenofibrate and isoxepac and the synthesis of a precursor of Zoloft III.

Referemce:
Alcohol – Wikipedia,
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Yu, Wensheng team published research in Bioorganic & Medicinal Chemistry Letters in 2021 | 16545-68-9

Reference of 16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Yu, Wensheng;Deng, Yongqi;Hopkins, Brett;Huang, Xianhai;Sloman, David;Zhang, Hongjun;Li, Derun;McGowan, Meredeth A.;White, Catherine;Pu, Qinglin;Liu, Kun;Fradera, Xavier;Lesburg, Charles A.;Martinot, Theo;Doty, Amy;Ferguson, Heidi;Nickbarg, Elliott B.;Cheng, Mangeng;Geda, Prasanthi;Song, Xuelei;Smotrov, Nadya;Abeywickrema, Pravien;Andrews, Christine;Chamberlin, Chad;Mabrouk, Omar;Curran, Patrick;Richards, Matthew;Saradjian, Peter;Miller, J. Richard;Knemeyer, Ian;Otte, Karin;Vincent, Stella;Sciammetta, Nunzio;Bennett, David Jonathan;Han, Yongxin research published 《 SAR towards indoline and 3-azaindoline classes of IDO1 inhibitors》, the research content is summarized as follows. A novel series of IDO1 inhibitors have been identified with good IDO1 Hela cell and human whole blood activity. These inhibitors contain an indoline or a 3-azaindoline scaffold. Their structure-activity-relationship studies have been explored. Compounds 37 (I) and 41 (II) stood out as leads due to their good potency in IDO1 Hela assay, good IDO1 unbound hWB IC₅₀s, reasonable unbound clearance, and good MRT in rat and dog PK studies.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Zhenbo team published research in Nature Communications in 2020 | 16545-68-9

In general, the hydroxyl group makes alcohols polar. 16545-68-9, formula is C3H6O, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Safety of Cyclopropanol

Yuan, Zhenbo;Zeng, Yuye;Feng, Ziwen;Guan, Zhe;Lin, Aijun;Yao, Hequan research published 《 Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes》, the research content is summarized as follows. A palladium-catalyzed asym. tandem Heck/carbonylation desymmetrization of cyclopentenes I (R = COMe, CO₂Et; R¹ = H, F, Cl, Me, OMe; X = I, Br) has been described. Alcs., (such as., n-propanol, isopropanol, cyclohexanol, etc.) phenols (such as., 4-methylphenol, biphenyl-4-ol, naphthol, etc.) and amines (such as., pyrrolidine, morpholine, benzylamine, etc.) are employed as versatile coupling reagents for the construction of multifunctional chiral bicyclo[3.2.1]octanes II (R² = OMe, OEt, OPh, pyrrolidino, morpholino, thiomorpholino, etc.) with one all-carbon quaternary and two tertiary carbon stereogenic centers in high diastereo- and enantioselectivities. This study represents an important progress in both the asym. tandem Heck/carbonylation reactions and enantioselective difunctionalization of internal alkenes.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xue, Lian team published research in Journal of Medicinal Chemistry in 2019 | 16545-68-9

HPLC of Formula: 16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Xue, Lian;Shi, Da-Hua;Harjani, Jitendra R.;Huang, Fei;Beveridge, Julia G.;Dingjan, Tamir;Ban, Kung;Diab, Sarah;Duffy, Sandra;Lucantoni, Leonardo;Fletcher, Sabine;Chiu, Francis C. K.;Blundell, Scott;Ellis, Katherine;Ralph, Stuart A.;Wirjanata, Grennady;Teguh, Silvia;Noviyanti, Rintis;Chavchich, Marina;Creek, Darren;Price, Ric N.;Marfurt, Jutta;Charman, Susan A.;Cuellar, Matthew E.;Strasser, Jessica M.;Dahlin, Jayme L.;Walters, Michael A.;Edstein, Michael D.;Avery, Vicky M.;Baell, Jonathan B. research published 《 3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity》, the research content is summarized as follows. A series of 3,3′-disubstituted 5,5′-bi(1,2,4-triazine) derivatives was synthesized and screened against the erythrocytic stage of Plasmodium falciparum 3D7 line. The most potent dimer, I, with an IC₅₀ (50% inhibitory concentration) of 0.008 μM, had high in vitro potency against P. falciparum lines resistant to chloroquine (W2, IC₅₀ = 0.0047 ± 0.0011 μM) and artemisinin (MRA1240, IC₅₀ = 0.0086 ± 0.0010 μM). Excellent ex vivo potency of I was shown against clin. field isolates of both P. falciparum (IC₅₀ = 0.022-0.034 μM) and Plasmodium vivax (IC₅₀ = 0.0093-0.031 μM) from the blood of outpatients with uncomplicated malaria. Despite I being cleared relatively rapidly in mice, it suppressed parasitemia in the Peters 4-day test, with a mean ED₅₀ value (50% ED) of 1.47 mg kg^-1 day^-1 following oral administration. The disubstituted triazine dimer I represents a new class of orally available antimalarial compounds of considerable interest for further development.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Chaofu team published research in Bioorganic Chemistry in 2020 | 16545-68-9

Yang, Chaofu;Wang, Jing;Cheng, Yunyun;Yang, Xu;Feng, Yan;Zhuang, Xiaomei;Li, Zhenwang;Zhao, Wangyu;Zhang, Jiwen;Sun, Xianyu;He, Xinhua research published 《 N-Quinary heterocycle-4-sulphamoylbenzamides exert anti-hypoxic effects as dual inhibitors of carbonic anhydrases I/II》, the research content is summarized as follows. Acute mountain sickness (AMS) affects approx. 25-50% of newcomers to high altitudes. Two human carbonic anhydrase isoforms, hCA I and II, play key roles in developing high altitude illnesses. However, the only FDA-approved drug for AMS is acetazolamide (AAZ), which has a nearly 100 times weaker inhibitory activity against hCA I (K_i = 1237.10 nM) than hCA II (K_i = 13.22 nM). Hence, developing potent dual hCA I/II inhibitors for AMS prevention and treatment is a critical medical need. Here we identified N-quinary heterocycle-4-sulphamoylbenzamides as potent hCA I/II inhibitors. The newly designed compounds 2b, 5b, 5f, 6d, and 6f possessed the desired inhibitory activities (hCA I: Ki = 16.95-52.71 nM; hCA II: K_i = 8.61-18.64 nM). Their hCA I inhibitory capacity was 22- to 76-fold stronger than that of AAZ. Relative to the control group for survival in a mouse model of hypoxia, 2b and 6d prolonged the survival time of mice by 21.7% and 29.3%, resp., which was longer than those of AAZ (6.5%). These compounds did not display any apparent toxicity in vitro and in vivo. In addition, docking simulations suggested that the quinary aromatic heterocycle groups stabilized the interaction between hCA I/II and the inhibitors, which could be further exploited in structure optimization studies. Hence, future functional studies may confirm 2b(I) and 6d(II) as potential clin. candidate compounds with anti-hypoxic activity against AMS.

Referemce:
Alcohol – Wikipedia,
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Yang, Gan team published research in Journal of Geophysical Research: Atmospheres in 2022 | 16545-68-9

Yang, Gan;Huo, Juntao;Wang, Lihong;Wang, Yuwei;Wu, Shijian;Yao, Lei;Fu, Qingyan;Wang, Lin research published 《 Total OH Reactivity Measurements in a Suburban Site of Shanghai》, the research content is summarized as follows. Total hydroxyl radicals (OH) reactivity, as a measure of the OH total loss rate and the significance of atm. oxidation, is broadly used to evaluate the OH budget in the atm. Here, measurements of the total OH reactivity were performed at a suburban air quality monitoring supersite (Dianshan Lake) of Shanghai, between 1 August and 15 Sept., 2020, using the Comparative Reactivity Method. The measured total OH reactivity ranged from 13.9 to 107.4 s^-1 with an average of 38.4 s^-1. Meanwhile, the calculated total OH reactivity varied between 8.9 and 84.4 s^-1 from concentrations of atm. trace gases measured by multiple in-situ techniques including an online gas chromatograph equipped with mass spectrometry and flame ionization detection (GC-MS/FID) and two proton-transfer-reaction time-of-flight mass spectrometers (PTR-ToF-MSs). A 12.1missing OH reactivity was evident from the comparison between the measured and calculated total OH reactivities. Inorganic trace gases, methane, and 54 observed Photochem. Assessment Monitoring Station compounds detected by GC-MS/FID, accounted for 25.7, 1.3, and 10, resp., of the calculated total OH reactivity. In addition, 292 species detected by PTR-ToF-MSs contributed the rest 63. The top 10 VOC contributors to the measured total OH reactivity were C₅H₈, CH₂O, C₂H₄O, C₆H₆O, C₄H₈O, C₃H₆O, C₁₀H₁₆, C₅H₁₀O, C₅H₈O₂, and C₈H₁₀, resp., whose total contribution reached 42. Correlation anal. for the missing OH reactivity suggests that primary biogenic VOCs could be a potential source for the missing OH reactivity during the daytime, and that secondary oxidation products might also be connected to the missing OH reactivity.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts