Category: 163119-16-2

Application of 163119-16-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 163119-16-2, name is 2,6-Di-tert-butyl-4-methylcyclohexanol, molecular formula is C15H30O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of 186 g of Compound (I-7) and 272 g of the foregoing Intermediate (I-6) suspended in 1.4 liter of ethyl acetate, 161 g of potassium acetate and 387 ml of anhydrous acetic acid were added in this order and stirred at 45 C. for 3 hours on a steam bath to react them. Thereafter, the reaction mixture was cooled on an ice bath and then 1 liter of water was added. Following stirring for 1 hour while cooling on an ice bath, precipitated crystals were collected by filtration. The crystals were washed with water. Crystals thus obtained were suspended in 1.5 liters of methanol and then 400 ml of a 25% aqueous ammonia was added. The resulting mixture was stirred at 40 C. for 3 hours on a hot water bath and then cooled on an ice bath and subjected to neutralization with dilute hydrochloric acid. Precipitated crystals were collected by filtration. The crystals were washed with water and dried. As a result, 291 g (yield 66%) of the objective Intermediate (I-8) was obtained, as a white crystal.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 163119-16-2, 2,6-Di-tert-butyl-4-methylcyclohexanol.

Reference:
Patent; Fuji Photo Film Co., Ltd.; US6649771; (2003); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 163119-16-2, name is 2,6-Di-tert-butyl-4-methylcyclohexanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 2,6-Di-tert-butyl-4-methylcyclohexanol

Synthesis of malonic acid ethyl 2,6-di-tert-butyl-4-methylcyclohexyl ester (d) Trifluoroacetic anhydride (41 ml, 0.29 mol) was added, dropwise, to a solution of the above 2,6-di-tert-butyl-4-methylcyclohexanol (d) (50.2 g, 0.22 mol) in ethyl acetate (200 ml) at 0C, and then the above malonic acid ethyl ester monopotassium salt (b) (41.6 g) was added thereto, slowly. After stirring it at room temperature for 2 hours, 200 ml of water was added thereto, and then 33 g of sodium hydrogencarbonate was added, slowly, to neutralize the reaction mixture. The organic layer was separated, washed with water once, and then with brine once; then it was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, to obtain crude malonic acid ethyl 2,6-di-tert-butyl-4-methylcyclohexyl ester (d) (76 g). The thus obtained crude malonic acid ethyl 2,6-di-tert-butyl-4-methylcyclohexyl ester (d) was used directly in the next step without purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 163119-16-2, 2,6-Di-tert-butyl-4-methylcyclohexanol.

Reference:
Patent; FUJI PHOTO FILM CO., LTD.; EP720981; (1996); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 163119-16-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 163119-16-2, name is 2,6-Di-tert-butyl-4-methylcyclohexanol, molecular formula is C15H30O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Cyanoacetic acid 46.8 g (0.55 mol), toluene 320ml was added to 2,6-di-tert-butyl-4-methylcyclohexanol 113 g (0.5 mol), subjected to stirring at room temperature, whereas, pyridine 43 .5g the (0.55mol) was dropped. Then, dropping acetic anhydride 112.3g (1.1mol), it was 15 hours heated and stirred at 60C. After completion of the reaction, the reaction solution, sodium hydrogen carbonate of 95g, poured slowly with stirring in an aqueous solution consisting of water 750ml. Then, extracted with ethyl acetate of 250ml, after concentrating the ethyl acetate layer, the methanol 400ml added to the residue, after being heated and dissolved at 60C , to precipitate a crystal was cooled to 0C It was. The crystals were filtered, washed with water, by performing the methanol wash, to afford intermediate 4 135g (92% yield).

According to the analysis of related databases, 163119-16-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FUJIFILM CORPORATION; SASAKI, DAISUKE; (63 pag.)JP5908824; (2016); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts