Category: 162358-05-6

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 162358-05-6, name is 2-(4-Octylphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. name: 2-(4-Octylphenyl)ethanol

Example 17 Preparation of 4-octylphenethyl methanesulfonate 2-(4-Octylphenyl)ethanol (53 g) and dichloromethane (500 mL) are charged into a 1 liter three-neck round bottom flask equipped with guard tube and addition funnel. Triethylamine (83.5 g) is added, the mixture is stirred for 30 minutes, then it is cooled to 0 C. Methanesulphonyl chloride (35.2 mL) is added drop-wise at 0 C. and the mass is stirred for 3 hours at room temperature. The mass is diluted with water (700 mL) and the organic layer is separated and the aqueous layer is extracted with dichloromethane (2*250 mL). The combined organic layers is washed with saturated sodium bicarbonate (500 mL) and brine solution (500 mL). The organic layer is separated, dried with sodium sulphate, and concentrated under vacuum to obtain the title compound. Yield: 70 g.

With the rapid development of chemical substances, we look forward to future research findings about 162358-05-6.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; Katkam, Srinivas; Sagyam, Rajeswar Reddy; Morthala, Raghavendar Rao; Ireni, Babu; Vinigari, Krishna; Ramdoss, Suresh Kumar; Rangineni, Srinivasulu; Tummala, Arjunkumar; Iqbal, Javed; Oruganti, Srinivas; Kandagatla, Bhaskar; US2014/235895; (2014); A1;,
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Reference of 162358-05-6, Adding some certain compound to certain chemical reactions, such as: 162358-05-6, name is 2-(4-Octylphenyl)ethanol,molecular formula is C16H26O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 162358-05-6.

(1) 2-(4-Octylphenyl)ethyl iodide To a solution of 2-(4-octylphenyl)ethanol (25 g) in ether (200 ml)-acetonitrile (100 ml), imidazole (11 g) and triphenylphosphine (36 g) were added and the mixture was stirred at 0 C. for an hour. Iodine (38 g) was added to the solution and the whole mixture was stirred at 0 C. for 2 hours. Silica gel was added to the reaction solution and the mixture was filtered off. The precipitate was washed with a mixed solution of hexane-ethyl acetate (2:1). The filtrate and the solvent employed at washing were combined and concentrated. The residue was purified by silica gel chromatography (eluent; hexane-ethyl acetate=2:1) to give the subject compound (37 g). Rf value: 0.85 (hexane-ethyl acetate=4:1) MS: 344(M+) 1 H-NMR(400 MHz, CDCl3) delta: 0.88 (3H, t, J=8 Hz), 1.10-1.40 (10H, m), 1.50-1.65 (2H, m), 2.57 (2H, t, J=8 Hz), 3.14 (2H, t, J=8 Hz), 3.33 (2H, t, J=8 Hz), 7.09 (2H, d, J=8 Hz), 7.13 (2H, d, J=8 Hz)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 162358-05-6, 2-(4-Octylphenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yoshitomi Pharmaceutical Industries, Ltd.; US5948820; (1999); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 162358-05-6, name is 2-(4-Octylphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C16H26O

General procedure: To a solution of 11 (400 mg, 1.71 mmol) and triethylamine (2 mL) in CH2Cl2 (10 mL) at 0 C was added methanesulfonyl chloride (0.66 mL, 8.53 mmol). After being stirred at room temperature for 6 h, the reaction mixture was evaporated, diluted with water, and the product was extracted with EtOAc. The extract was washed with brine, dried, and evaporated. To a solution of the reaction mixture (300 mg, 0.96 mmol) in DMF (10 mL) was added sodium azide (187 mg, 2.88 mmol). After the reaction mixture was heated at 80 C for 12 h, saturated aqueous ammonium chloride solution was added, and the mixture was extracted with EtOAc. The reaction mixture 15 (200 mg) was dissolved in EtOAc (10 mL), and 10% Pd/C (20 mg, 10 wt %) was added. After the reaction mixture was hydrogenated at room temperature for 12 h, the catalyst was removed by filtration through a pad of Celite, which was rinsed with EtOAc. Product 17 was obtained, without purification, as a colorless oil.

With the rapid development of chemical substances, we look forward to future research findings about 162358-05-6.

Reference:
Note; Oh, Yoon Sin; Lee, Taeho; Shin, Sang Mi; Shrestha, Jitendra; Lee, Doohyun; Park, Eun-Young; Baek, Dong Jae; Bulletin of the Korean Chemical Society; vol. 39; 2; (2018); p. 261 – 264;,
Alcohol – Wikipedia,
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Related Products of 162358-05-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 162358-05-6, name is 2-(4-Octylphenyl)ethanol. A new synthetic method of this compound is introduced below.

Example 6 Preparation of Compound of Formula VIIIn a round bottom flask, 600 ml of methylene chloride was charged and 100 gm of compound of Formula V, obtained as in Example 4, and 5.0 gm of DMAP and 110 gm of triethyl amine was added. The reaction mass was stirred for about 10 minutes and cooled at about 0-5 C. 75 gm of methane sulphonyl chloride was added at about 0-5 C. and the temperature of reaction mass was raised to about 25-30 C. The reaction mass was stirred at about 25-30 C. for about 1 hour and water (500 ml) was added to the reaction mass. The pH was adjusted to about 2-4 by using aq. HCl and the reaction mass was stirred for about 20 min. The organic layer was separated and washed with 7% bicarbonate solution followed by washing with brine. The organic layer was treated with charcoal and distilled out under vacuum and degassed to get 110 gm of compound of Formula VI.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,162358-05-6, 2-(4-Octylphenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Glenmark Generics Limited; Gharpure, Milind; Narawade, Krishna; Chand, Prem; Bhirud, Shekhar; US2015/18578; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 162358-05-6, name is 2-(4-Octylphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. 162358-05-6

4-Octylphenethyl Methanesulfonate (Scheme 4). To a solution of 4-octylphenethyl alcohol (200 mg, 0.853 mmol) and triethylamine (1.19 mL, 8.53 mmol) in CH2C12 (8 mL) at 0 C was added methanesulfonyl chloride (0.33 mL, 4.27 mmol). After being stirred at rt for 5 h, the reaction mixture was evaporated, diluted with water, and the product was extracted with EtOAc. The extract was washed with brine, dried, and evaporated. Purification by silica gel chromatography, eluting with hexanes/EtOAc (5: 1), gave 253 mg (95%) of the mesylate as a yellow liquid; 1H NMR (400 MHz, CDC13) delta 0.87 (t, J = 6.9 Hz, 3H), 1.26- 1.30 (m, 10H), 1.58 (m, 2H), 2.57 (t, = 7.7 Hz, 2H), 2.83 (s, 3H), 3.02 (t, = 7.0 Hz, 2H), 4.40 (t, = 7.0 Hz, 2H), 7.14 (s, 4H); 13C NMR (100 MHz, CDC13) delta 14.1, 22.7, 29.3 (2C), 29.5, 31.6, 31.9, 35.3, 35.6, 37.3, 70.6, 128.8, 128.9, 133.4, 141.9; ESI-HRMS (M + Na)+ mlz calcd for Ci7H28Na03S 335.1657, found 335.1655.

Statistics shows that 162358-05-6 is playing an increasingly important role. we look forward to future research findings about 2-(4-Octylphenyl)ethanol.

Reference:
Patent; RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK; UNIVERSITY OF STRATHCLYDE; BITTMAN, Robert; PYNE, Nigel J.; PYNE, Susan; BAEK, Dong Jae; LIU, Zheng; BYUN, Hoe Sup; WO2014/118556; (2014); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts