Category: 161446-90-8

Related Products of 161446-90-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 161446-90-8, name is 3-Chloro-4-fluorobenzyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows.

Example 222 4- ( (3-Chloro-4-fluorobenzyl) oxy) -1- (2- ( (1RS,2SR) -2- (2- hydroxypropan-2-yl ) cyclopropyl) -l-methyl-lH-benzimidazol-6- yl) pyridin-2 (1H) -one To a mixture of. 4-hydroxy-l- (2- ( ( IRS, 2SR) -2- (2- hydroxypropan-2-yl ) cyclopropyl) -l-methyl-lH-benzimidazol-6- yl) pyridin-2 (1H) -one (100 mg) , (3-chloro-4- fluorophenyl) methanol (95 mg) , tributylphosphine (0.219 ml) and THF (10 ml) was added 1, 1′ – (azodicarbonyl) dipiperidine (223 mg) , and the mixture was stirred at 60C for 2 h. The reaction mixture was diluted with EtOAc, washed with water and brine successively, dried over MgS04, filtered through a plug of NH silica gel, and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane/EtOAc then EtOAc/MeOH) , followed by NH silica gel column chromatography (hexane/EtOAc) . Then the resulting solid was recrystallized from IPA-EtOAc to give the title compound (58.4 mg) as an off-white solid. MS (ESI+) : [M+H] + 482.2. XH NMR (400 MHz, DMSO-d6) : delta 1.09 (6H, s) , 1.23-1.32 (1H, m) , 1.36-1.44 (1H, m) , 1.56-1.66 (1H, m) , 2.22-2.31 (1H, m) , 3.86 (3H, s), 5.18 (2H, s) , 5.86 (1H, s) , 5.98 (1H, d, J = 2.3 Hz), 6.13 (1H, dd, J = 2.3, 7.8 Hz), 7.09 (1H, d, J = 8.4 Hz), 7.35 (1H, d, J = 7.9 Hz), 7.51-7.59 (3H, m) , 7.60-7.70 (2H, m) .

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 161446-90-8, 3-Chloro-4-fluorobenzyl Alcohol.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KASAI, Shizuo; IGAWA, Hideyuki; TAKAHASHI, Masashi; MAEKAWA, Tsuyoshi; KAKEGAWA, Keiko; YASUMA, Tsuneo; KINA, Asato; AIDA, Jumpei; KHAMRAI, Uttam; KUNDU, Mrinalkanti; WO2013/105676; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 161446-90-8, name is 3-Chloro-4-fluorobenzyl Alcohol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

Intermediate 50 (1.25 mmol), triphenylphosphine (1.87 mmol) and carbon tetrabromide (1.87 mmol) were stirred in anhydrous DCM, under nitrogen for 3 hours. The solvent was removed under reduced pressure and the crude material was purified by chromatography on silica gel to give intermediate 51, which was a colourless oil. Intermediate 51 was characterized by the following spectroscopic data: 1H NMR (DMSO-d6, 400 MHz) (ppm) 4.43 (s, 2H), 7.13 (t, J=8.37 Hz, 1H), 7.26-7.28 (m, 1H), 7.44-7.47 (d, J=6.70 Hz, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 161446-90-8, 3-Chloro-4-fluorobenzyl Alcohol.

Reference:
Patent; Idenix Pharmaceuticals, Inc.; US2009/60866; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 161446-90-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 161446-90-8, name is 3-Chloro-4-fluorobenzyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows.

[00202] A solution of 3-chloro-4-fluorobenzaldehyde (3 g) in THF (40 ml) was added over 2 minutes to a stirred suspension of sodium borohydride (1.07 g) in methanol (40 ml) at 0 C. The mixture was allowed to warm to room temperature and then quenched with water. The resulting suspension was partitioned between water and diethyl ether and the combined organic extracts were dried and concentrated in vacuo. The residue was dissolved in dichloromethane (90 ml) and triphenylphosphine (4.62 g) and tetrabromomethane (6.64 g) were added at 0 C. The mixture was allowed to warm to room temperature overnight then concentrated in vacuo and the residue purified by column chromatography using iso-hexane as eluent to yield the desired product (3.57 g, 85%). NMR: delta 4.7 (s, 2H), 7.4 (m, 2H), 7.7 (m, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 161446-90-8, 3-Chloro-4-fluorobenzyl Alcohol.

Reference:
Patent; AstraZeneca AB; US6737435; (2004); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts