Electric Literature of 15852-73-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15852-73-0, name is (3-Bromophenyl)methanol, molecular formula is C7H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a cold (0 C) solution of 3-bromophenylethanol (39) (50 g, 267 mmol) and imidazole (27 g, 401 mmol) in DMF (500 mL) was added tert-butylchlorodiphenylsilane (83 mL, 320 mmol) and the mixture was warmed up to rt then stirred at rt for 8 h. To the reaction mixture was added saturated aqueous ammonium chloride solution and EtOAc. The organic layer was separated and washed with brine then dried over MgSO4, filtered and evaporated in vacuo. The resulting residue was purified by column chromatography on silica gel (EtOAc-hexane) to give the title compound (40) (117 g, quant.) as a white solid.1H NMR (CDCl3) delta: 1.10 (9H, s), 4.72 (2H, s), 7.16-7.27 (2H, m), 7.35-7.48 (8H, m), 7.66-7.69 (4H, m). MS (FAB) m/z: 425 (M+), calcd for C23H25BrOSi: 425.
According to the analysis of related databases, 15852-73-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Imamura, Masakazu; Nakanishi, Keita; Suzuki, Takayuki; Ikegai, Kazuhiro; Shiraki, Ryota; Ogiyama, Takashi; Murakami, Takeshi; Kurosaki, Eiji; Noda, Atsushi; Kobayashi, Yoshinori; Yokota, Masayuki; Koide, Tomokazu; Kosakai, Kazuhiro; Ohkura, Yasufumi; Takeuchi, Makoto; Tomiyama, Hiroshi; Ohta, Mitsuaki; Bioorganic and Medicinal Chemistry; vol. 20; 10; (2012); p. 3263 – 3279;,
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